|Products||Total T4 EIA Test|
|Company||Diagnostic Systems Laboratories, Inc.|
|Item||Total T4 EIA Test|
|Description|| Thyroxine (T4) is the primary active hormone synthesized within the follicular cells of the thyroid gland . T4 is synthesized via a series of steps involving: (i) iodide trapping by the follicular cells, (ii) iodination of tyrosine residues in the thyroglobulin substrate leading to formation of 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT and DIT), and (iii) coupling of MIT and DIT to form either T4 or T3 (triiodothyronine). The production of T4 is approximately 3 times greater than that of T3. In plasma, ~70% of T4 is bound to thyroxine-binding globulin (TBG), 15-25% to transthyretin, 5-15% to albumin and a small percentage is bound to erythrocytes [1,2]. Less than 0.1% of the total T4 circulates in a free or unbound form. T4 binds to specific cell receptors and has diverse cellular and somatic effects. Measurement of total serum T4 levels is a standard and well-validated test of thyroid gland function .
|Info|| Diagnostic Systems Laboratories, Inc.|
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