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Total PSA IRMA Test

ProductsTotal PSA IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Total PSA IRMA Test
Features 
  • Requires only 50 L sample to test
  • No sample pretreatment required
  • Incubation is 2 hrs + 1 hr on shaker at RT
  • Description Prostate-Specific Antigen (PSA) derives its name from its first known site of origin, the prostate gland. The majority of PSA circulates bound to anti-chymotrypsin (PSA-ACT) and other compounds. Serum concentrations of PSA are elevated in patients with prostate cancer, benign prostatic hypertrophy (BPH) and prostatitis [1-3]. In addition, PSA serum levels appear to correlate with the volume and clinical stage of prostate cancer [1,4]. Selective determination of the various forms of PSA (i.e. free PSA, PSA-ACT complex and total PSA) may be useful to distinguish BPH from untreated prostate cancer. The ratio of free PSA to PSA-ACT is lower in untreated prostate cancer patients than in normal individuals or in patients with BPH. Thus, in patients with PSA in the 4 to 10 mg/L range (diagnostic gray zone), determination of free PSA fractions as a percentage of the total levels (i.e. the free PSA percentage) has been proposed as a means to improve discrimination between BPH and untreated prostate cancer in patients [1,3,5,6].

    It has been found that PSA is not specific to the prostate. There are a number of non-prostatic sources of PSA, such as the periurethral glands, breast cancer tissues, breast fluids, amniotic fluid and other [7]. Urinary PSA has also been measured in women with hyperandrogenic syndromes such as polycystic ovarian syndrome [8].

    1. Vessella RL. Clin Chem 39:2035, 1993.
    2. Papsidero LD, et al. Cancer Res 40:2428, 1980.
    3. Kuriyama M, et al. Cancer Res 40:4658, 1980.
    4. Graves HCB. Clin Chem 38:1930, 1992.
    5. Lilja H, et al. Clin Chem 37:1618, 1991.
    6. Stenman UH, et al. Cancer Res 51:222, 1991.
    7. Diamandis EP & Yu H. Urol Clin North Am 24:275-282, 1997.
    8. Obiezu CV et al. J Clin Endocrinol Metab 86:1558-1561, 2001.
    Info Diagnostic Systems Laboratories, Inc.
    Customer Service: (800) 231-7970
    Web site: http://www.dslabs.com

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