Navigation Links

ProductsTSH IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item TSH IRMA Test
Description Thyroid-stimulating hormone (TSH) is a 32 kDa glycoprotein secreted by the thyrotrope cells of the anterior pituitary gland [1]. The structure of human TSH is similar to that of the pituitary and placental gonadotropins, consisting of an a-subunit which is similar or identical between these hormones and a unique beta-subunit, which confers hormonal specificity. TSH stimulates production of thyroid hormones by binding to thyrocyte membrane receptors, leading to stimulation of cAMP-dependent iodine transport and resultant thyroid hormone synthesis [2]. TSH secretion is stimulated by thyrotropin-releasing hormone (TRH) which is secreted by the hypothalamus and is regulated at both the pituitary and hypothalamic levels by thyroid hormones. Low levels of thyroid hormones lead to increased TSH secretion and elevated thyroid hormone levels lead to decreased TSH secretion.

During human fetal life, serum TSH levels are measurable at about 18 weeks gestation and increase to a peak at the beginning of the 3rd trimester. At birth, a sharp and dramatic increase in serum TSH levels occurs with a subsequent rapid decline over several hours [3]. Postnatal secretion of TSH is relatively age- and sex-independent and occurs in a circadian pattern with a nadir in the late afternoon and a peak at approximately midnight. Measurement of serum TSH levels have been used in the diagnostic evaluation and therapeutic monitoring of primary hypo- and hyper-thyroidism. In addition, measurement of TSH levels following parenteral administration of TRH has been used in the evaluation of TSH-deficiency [4].

  1. Magner JA. Endocrin Rev 11:354-385, 1990.
  2. Vassart G & Dumont JE. Endocrin Rev 13:596-611, 1992.
  3. Fisher DA & Klein AH. N Engl J Med 304: 702-712, 1981.
  4. Alsever RN & Gotlin RW. Handbook of Endocrine Tests in Adults and Children, second edition. Year Book Medical Pub, Chicago, 1978, pp 22-25.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site:

Related medicine products :

1. Laserex Tango M (Total Mobile Version)
2. Bilirubin, Direct & Total
3. Bilirubin Total Reagent
4. Total Bilirubin Reagent
5. Total Protein
6. Total Protein Reagent
7. Total Protein Reagent Set
8. Iron Total (TIBC)
9. Iron (Total/Ferene)
10. Cholesterol, Total
11. Total Internal Reflection Fluorescence Microscopy
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
... Many special order products are offered ... extra long lengths. The modular instruments may ... other options such as ratchets, insulation and ... from Mediflex stock. Customer specifications may affect ...
... order products are offered as 1-piece or ... The modular instruments may be customized with ... as ratchets, insulation and flush ports. Many ... Customer specifications may affect delivery times. ...
... products are offered as 1-piece or modular, ... modular instruments may be customized with handles ... ratchets, insulation and flush ports. Many standard ... specifications may affect delivery times. , ...
Medicine Products:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
Breaking Medicine Technology: