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SHBG IRMA Test

ProductsSHBG IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item SHBG IRMA Test
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Description Human sex hormone-binding globulin (SHBG) is a serum glycoprotein which binds several sex steroids with relatively high specificity and low capacity, including testosterone and dihydrotestosterone (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specifically binds C18 and C19 steroid structures and regulates the bioavailability of sex steroids. SHBG is produced primarily in the liver. SHBG synthesis and release are regulated by a number of factors which lead to increased ( i.e. thyroid hormones, estrogens, stress, male aging, phenytoin, high carbohydrate intake) or decreased (i.e. obesity, testosterone, prolactin, growth hormone, female aging-menopause, progestins, glucocorticoids) serum levels [2]. Abnormal serum SHBG levels have been reported in a number of conditions, including obesity and female hyperandrogenism (including polycystic ovary disease) [1,2]. Serum SHBG levels are inversely related to free, presumably bioactive, testosterone concentrations, and as a result a free testosterone index based on the ratio of total testosterone to SHBG has been characterized [3,4].

  1. Hammond GF. Endocrin Rev 11:65-79, 1990.
  2. Rosner W. Endocrin Rev 11:80-91, 1990.
  3. Mathur RS, et al. Fertil Steril 35:29-35, 1981.
  4. Nanjee MN & Wheeler MJ. Ann Clin Biochem 22:387-390, 1985.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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