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PYY, Total ELISA Test

ProductsPYY, Total ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item PYY, Total ELISA Test
Description Peptide YY (PYY) was first identified in 1980 (1) and has only recently been appreciated as a hormonal regulator of appetite (2). PYY is produced by the gut and released into the circulation after food intake, and is found to decrease appetite. The main form of PYY both stored and in the circulation is PYY3-36, the N-terminal truncated form of the full length peptide (3). In common with leptin, this peptide has been shown to cross the blood-brain-barrier and act on the arcuate nucleus of the hypothalamus, stimulating neurons that create a sensation of satiety and inhibiting neurons that stimulate feeding behavior (2). In a recent study (4), an infusion of PYY3-36 on appetite and food intake in 12 obese and 12 lean subjects demonstrated that, unlike leptin, there was no evidence of resistance to PYY3-36 in obese subjects. Endogenous levels of PYY3-36 were low in the obese subjects, suggesting that PYY3-36 deficiency may contribute to the pathogenesis of obesity and infusion of PYY3-36 caused a significant decrease in the cumulative 24-hour caloric intake in both obese and lean subjects. The same group of investigators has recently reported that pancreatic polypeptide has similar effects on energy homeostasis. These results are certainly of great interest and warrant further investigation.

  1. Tatemoto K & Mutt V Nature 285: 417-418, 1980.
  2. Batterham RL, et al. Nature 418: 650-654, 2002.
  3. Grandt D, et al. Regul Pept 51 : 151-159, 1994
  4. Batterham RL, et al. N Engl J Med 349: 941-948, 2003.
Info Diagnostic Systems Laboratories, Inc.
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