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ProductsPAPP-A ELISA Test
Company Diagnostic Systems Laboratories, Inc.
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Description Pregnancy-associated plasma protein A (PAPP-A) is a large placenta-derived glycoprotein [1]. PAPP-A is produced in high concentrations by placental trophoblast cells, and is released into the maternal circulation in increasing concentrations throughout gestation until delivery [1]. PAPP-A is not specific to pregnancy since measurable levels have been found in non-pregnant females and in males. [2]. The biological role of PAPP-A is unknown, however, it has been suggested that PAPP-A may serve as an important growth regulatory factor. It has been shown that PAPP-A specifically proteolyses insulin-like growth factor binding protein-4 (IGFBP-4), thereby regulating local IGF bioavailability and mitogenic effectiveness [3].

  1. Qin Q-P, et al. Clin Chem 43: 2323-2332, 1997
  2. Bischof P, et al. Arch Gynecol. 273: 109-116, 1986
  3. Conover CA et al. Development. 131(5):1187-1194, 2004
Info Diagnostic Systems Laboratories, Inc.
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