Navigation Links
Osteocalcin IRMA Test

ProductsOsteocalcin IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Osteocalcin IRMA Test
Features Inquire
Description Osteocalcin, also known as bone Gla protein, is a vitamin K-dependent, calcium binding protein which is a major component of the noncollagenous bone matrix [1,2,3]. Osteocalcin is synthesized by osteoblasts in bone, with a small amount produced by odontoblasts in dentin, and hypertrophic chondrocytes [1]. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into circulation. Because serum osteocalcin originates exclusively from bone, serum osteocalcin levels reflect bone formation activity [1]. Osteocalcin is also released into serum from the bone matrix during osteoblastic bone resorption. However, this circulates as non-immunoreactive fragments that are rapidly metabolized in the kidney and, to a lesser extent, in the liver [5]. Serum osteocalcin is elevated in disease states characterized by increased bone turnover such as renal osteodystrophy, osteoporosis, hyperparathyroidism and Pagets disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency [1]. Serum osteocalcin measurements are also useful in osteoporosis research, and have shown good correlation with bone histomorphometric measurements [6] and for studying the effects of treatments that modulate bone formation activity [7]. Serum osteocalcin measurements have also been useful in the research of toxic effects on bone [6,8].

  1. Gundberg CM. J Clin Ligand Assay 21:128-138, 1998.
  2. Price PA, et al. Proc Natl Acad Sci USA 73:3374-3375, 1976.
  3. Gallop PM, et al. New Engl J Med 302:1460, 1980.
  4. Price PA, et al. J Biol Chem 256:12760, 1981.
  5. Farrugia W & Melik RA. Calcif Tissue Int 39:234, 1986.
  6. Bikle DD. Am J Med 103:427-436, 1997.
  7. Castracane VD et al. J Bone Min Res 12:S500, 1997.
  8. Kido T et al. Arch Environ Hlth 46:43-49, 1991.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Osteocalcin ELISA Test
2. Osteocalcin by Electrochemiluminescent Immunoassay
... Sidekick Testing System is the smallest blood glucose ... there when you need it in your ... or simply in your purse or pocket.* Its ... you go. And, because it's so convenient it's ...
... newest member of the Xpect family, Xpect C. ... B in one rapid test. The simple-to-perform test ... in 20 minutes. ,The Remel Xpect family of ... of rapid, direct specimen tests that combine exceptional ...
Inquire...
Inquire...
Medicine Products:
(Date:8/19/2017)... Rockville, MD (PRWEB) , ... August 18, 2017 ... ... Food and Drug Administration Reauthorization Act of 2017, legislation that provides for greater ... perceived mild to moderate hearing loss to access OTC hearing aids without being ...
(Date:8/19/2017)... ... 19, 2017 , ... Curl Keeper® is excited to announce that the H2O ... 2017 Award for the second year in a row. The H2O Bottle, a refillable ... voted Best Moisturizer for Type 2 Wavies and Best Refresher for Type 2 Wavies ...
(Date:8/19/2017)... ... , ... Yesterday, the President of the United States retracted his condemnation of ... not two sides to hatred, bigotry, discrimination, and a white supremacy nationalist agenda. ... against all forms of such hatred and discrimination in this country and globally. ...
(Date:8/19/2017)... ... August 19, 2017 , ... ... has joined its Orlando location as an interventional pain management physician. He brings ... on the treatment of migraine headaches, and significant experience in spinal cord stimulation ...
(Date:8/18/2017)... Thailand (PRWEB) , ... August 19, 2017 , ... ... Business, Tourism Authority of Thailand presided over the Amazing Thailand Health and Wellness ... in Thailand. , Mr. Noppadon Pakprot, Deputy Governor for Tourism Products and Business ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017   Mostyn Law and ... Houston, Texas . The Mostyn Law ... past 2 years. That is why Mostyn Law is ... to show its appreciation. Blood supplies are ... fall 5% short of hospital needs in August. That is why ...
(Date:8/14/2017)... and PETACH TIKVAH, Israel , ... BCLI), a leading developer of adult stem cell technologies ... quarter ending June 30, 2017. ... preparing for our pivotal Phase 3 trial to investigate ... , President and Chief Executive Officer of BrainStorm. "We ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin Health, ... acquisition, retention, and engagement, announced the selection of ... and Product Development, effective as of February 2017. In ... technology implementation strategy for our clients. Wood brings ... in consulting and business analytics within the healthcare ...
Breaking Medicine Technology: