Navigation Links
Osteocalcin IRMA Test

ProductsOsteocalcin IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Osteocalcin IRMA Test
Features Inquire
Description Osteocalcin, also known as bone Gla protein, is a vitamin K-dependent, calcium binding protein which is a major component of the noncollagenous bone matrix [1,2,3]. Osteocalcin is synthesized by osteoblasts in bone, with a small amount produced by odontoblasts in dentin, and hypertrophic chondrocytes [1]. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into circulation. Because serum osteocalcin originates exclusively from bone, serum osteocalcin levels reflect bone formation activity [1]. Osteocalcin is also released into serum from the bone matrix during osteoblastic bone resorption. However, this circulates as non-immunoreactive fragments that are rapidly metabolized in the kidney and, to a lesser extent, in the liver [5]. Serum osteocalcin is elevated in disease states characterized by increased bone turnover such as renal osteodystrophy, osteoporosis, hyperparathyroidism and Pagets disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency [1]. Serum osteocalcin measurements are also useful in osteoporosis research, and have shown good correlation with bone histomorphometric measurements [6] and for studying the effects of treatments that modulate bone formation activity [7]. Serum osteocalcin measurements have also been useful in the research of toxic effects on bone [6,8].

  1. Gundberg CM. J Clin Ligand Assay 21:128-138, 1998.
  2. Price PA, et al. Proc Natl Acad Sci USA 73:3374-3375, 1976.
  3. Gallop PM, et al. New Engl J Med 302:1460, 1980.
  4. Price PA, et al. J Biol Chem 256:12760, 1981.
  5. Farrugia W & Melik RA. Calcif Tissue Int 39:234, 1986.
  6. Bikle DD. Am J Med 103:427-436, 1997.
  7. Castracane VD et al. J Bone Min Res 12:S500, 1997.
  8. Kido T et al. Arch Environ Hlth 46:43-49, 1991.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Osteocalcin ELISA Test
2. Osteocalcin by Electrochemiluminescent Immunoassay
... in the hand, the Jarvik 2000 pump is ... its welded titanium shell sits a direct-current motor, ... a single moving part: a small, spinning titanium ... up to 7 liters per minute. Rather than ...
... Implant is an endoscopic urethral implant ... (SUI). Upon implantation, the Tegress™ Implant ... (EVOH) in a Dimethyl Sulfoxide (DMSO) ... that reinforces the integrity of the ...
... Varicella-Zoster (VZ) test system is ... semi-quantitative detection of VZ IgG ... the indirect fluorescent antibody (IFA) ... or confirm a recent infection ...
... Trinity Biotech Captia™ Varicella-Zoster Virus ... (ELISA) is intended for the ... Varicella-Zoster virus in human serum ... diagnosis of primary infection or ...
Medicine Products:
(Date:6/27/2016)... ... June 27, 2016 , ... The OSHA ... Training Institute Education Center headquartered in Northern California, has issued an important reminder ... at their worksites. Employers with workers exposed to high temperatures should establish ...
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 One of Australia,s successful ... of a new biotechnology company, Noxopharm Limited [ABN 50 608 966 ... and to list on the ASX. Noxopharm is a ... enter a Phase 1 clinical study later this year. ... of the biggest problems facing cancer patients - the ability of ...
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/26/2016)... -- VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported today ... to build a strong and stable market for trading ... the OTC Markets-pink current trading platform. Explains ... seeing an anomaly in market trading activities that may ... Company, but shareholders and market players as well. I ...
Breaking Medicine Technology: