Navigation Links

ProductsMIS/AMH ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Features Inquire
Description Mullerian Inhibiting Substance (MIS), also known as Anti-Mullerian Inhibiting Substance (AMH), is a glycoprotein dimer composed of two 72 kDa monomers linked by disulfide bridges (1). MIS/AMH belongs to the transforming growth factor-? (TGF-?) superfamily which includes TGF-? and the various inhibin and activin glycoproteins (2). All members of this superfamily are dimeric glycoproteins, and all are involved in the regulation of tissue growth and differentiation. The human gene coding for MIS/AMH has been sequenced and isolated, and is located on the short arm of chromosome 19 (3). The structure of a specific receptor for MIS/AMH has also been isolated and characterized (4).

MIS/AMH is produced by the Sertoli cells of the testis in the male, and by ovarian granulosa cells in the female. During embryonic development in males, secretion of MIS/AMH from testicular Sertoli cells is essential for the regression of the Mullerian ducts, and thus the normal development of the male reproductive tract (5). The Mullerian ducts are the primordium for the uterus, Fallopian tubes and upper vagina in the female. In the male, secretion of MIS/AMH by the Sertoli cells commences during embryogenesis and continues throughout life. Levels drop following puberty, decreasing slowly to a relatively low post-puberty value (2). In the female, serum MIS/AMH is undetectable using immunoassay until the onset of puberty. Thereafter, circulating MIS/AMH is maintained at relatively low levels until menopause, at which time MIS/AMH falls again to undetectable levels (as measured by immunoassay).

Potential clinical applications for a specific MIS/AMH assay include: the investigation of ovarian reserve and the perimenopausal transition in women; the detection and management of granulosa cell tumors; the diagnosis of precocious puberty and conversely, its delayed onset in the young; the differential diagnosis of intersex disorders; the diagnosis of cryptoorchidism and anorchidism, and the evaluation of male gonadal function at all ages (2).

  1. Picard JY, Josso N Mol Cell Endocrinol 34: 23-29, 1984.
  2. Teixeira J et al. Endocrine Reviews 22: 657-674, 2001.
  3. Picard JY et al. Proc Natl Acad Sci 83: 5464-5468, 1986.
  4. di Clemente N et al. Mol Endocrinol 8: 1006-1020, 1994.
  5. Picon R Arch Anat Microsc Morphol Exp 58: 1-19, 1969.
  6. Hudson PL et al. J Clin Endocrinol Metab 70: 16-22, 1990.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site:

Related medicine products :

1. Microplate ELISA Washers - Manual Microplate Washer
2. Microplate ELISA Washers - Automated Microplate Washer
3. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
4. RELISA ANA Screening System
5. BioCheck hCG ELISA
6. Human Chorionic Gonadotropin (HCG) ELISA Kit
7. Human PSA ELISA Kit
8. Total PSA ELISA Test
10. PAP Microwell ELISA
11. Trinity Biotech Captia™ B. burgdorferi IgG/IgM ELISA
... products are offered as 1-piece or modular, ... modular instruments may be customized with handles ... ratchets, insulation and flush ports. Many standard ... specifications may affect delivery times. , ...
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
Medicine Products:
(Date:11/27/2015)... ... 2015 , ... Intellitec Solutions announced today that they have ... as Microsoft’s official group for end users of Dynamics SL ERP software, the ... experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing commitment to the ...
(Date:11/27/2015)... ... ... CBD College is proud to announce that on November 20th, ... its Diagnostic Medical Sonography program. CBD College is honored to join this very short ... universities in the state of California make the cut. CBD College is officially the ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., developer and ... of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 product line. ... 5.10 up-to-date with a version of Asterisk that will receive not only security ...
(Date:11/26/2015)... Ashburn, VA (PRWEB) , ... November 26, 2015 ... ... Planners, an American Express Travel Representative. As a franchise owner, Somu now offers ... range of cruise, destination wedding packages, private cruise sales, as well as, cabin ...
(Date:11/26/2015)... ... 2015 , ... WorldCare International, Inc., the first company to ... Benefits Conference. The Employee Benefits Conference was hosted by the International Foundation of ... 2015. The conference was held at the Hawaii Convention Center in Honolulu, Oahu, ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 ... addition of the "Global Brain Monitoring ... offering. --> ) has ... Brain Monitoring Devices Market 2015-2019" report ... and Markets ( ) has announced ...
(Date:11/25/2015)... 25, 2015  Linden Care, LLC, a retail specialty ... for patients suffering from chronic pain, said today that ... Restraining Order (TRO) enjoining Express Scripts from unilaterally terminating ... --> --> The company ... legal options. --> --> ...
(Date:11/25/2015)... 25, 2015  Henry Schein, Inc., the world,s largest ... dental, medical and animal health practitioners, will unveil at ... Henry Schein ConnectDental® Pavilion , which brings together for ... solutions designed to help any practice or laboratory enter ... for a schedule of experts appearing at the Pavilion. ...
Breaking Medicine Technology: