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Leptin Soluble Receptor ELISA Test

ProductsLeptin Soluble Receptor ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Leptin Soluble Receptor ELISA Test
Features Inquire
Description Leptin is a 16kDa peptide encoded by the ob gene and is produced exclusively by adipocytes. It is believed to play a key role in the regulation of body weight by influencing energy intake and expenditure [1,2]. Leptin functions as a lipostat and is produced by adipocytes in response to increasing fat stores. Increased serum leptin levels signal the brain to stop eating and increase energy expenditure. Conversely, declining fat stores result in reduced leptin secretion which signals the brain to counteract weight loss by increasing feed intake and decreasing energy expenditure [3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism provided by leptin to the brain is necessary for the precise regulation of long term energy balance [4]. Leptin expression and levels are consistently associated with body adiposity and body mass index (BMI) [4]. In humans, leptin levels are elevated with increasing adiposity in both men and women [5]. A relationship between serum leptin levels and several measures of adiposity demonstrates that leptin levels are elevated even in obese patients. This is contrary to earlier suggestions that obesity was the result of a leptin deficiency. The failure of elevated leptin levels to alter the obese state of these individuals may instead be related to a "leptin resistance" and an inability of leptin to enter the cerebral spinal fluid to reach receptors in the hypothalamus. Circulating leptin is also believed to be bound to a carrier protein. Whether this is a unique binding protein or represents a form of the leptin receptor remains unclear. However, this carrier protein may be an important regulator and may explain rapid changes in serum leptin levels that occur as a result of starvation or forced feeding.

Leptin may also play a role in other endocrine processes, including adaptation to starvation and the onset of puberty [6]. Recent studies have suggested that leptin is also produced by the human placenta indicating a role for leptin related to reproductive function [4].

  1. Blum WF, et al. J. Clin. Endocrinol. Metab. 82: 2904, 1997.
  2. Pelleymounter MA, et al. Science 269: 540-543, 1995.
  3. Gura T. Science 275: 751-753, 1997.
  4. Tritos NA. & Mantzoros CS. Diabetologia 40: 1371-1379, 1997.
  5. Considine RV, et al. N Engl J Med. 334: 292-295, 1996.
  6. Flier JS. Proc Natl Acad Sci USA. 94: 4242-4245, 1997.
Info Diagnostic Systems Laboratories, Inc.
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