Navigation Links
Leptin Soluble Receptor ELISA Test

ProductsLeptin Soluble Receptor ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Leptin Soluble Receptor ELISA Test
Features Inquire
Description Leptin is a 16kDa peptide encoded by the ob gene and is produced exclusively by adipocytes. It is believed to play a key role in the regulation of body weight by influencing energy intake and expenditure [1,2]. Leptin functions as a lipostat and is produced by adipocytes in response to increasing fat stores. Increased serum leptin levels signal the brain to stop eating and increase energy expenditure. Conversely, declining fat stores result in reduced leptin secretion which signals the brain to counteract weight loss by increasing feed intake and decreasing energy expenditure [3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism provided by leptin to the brain is necessary for the precise regulation of long term energy balance [4]. Leptin expression and levels are consistently associated with body adiposity and body mass index (BMI) [4]. In humans, leptin levels are elevated with increasing adiposity in both men and women [5]. A relationship between serum leptin levels and several measures of adiposity demonstrates that leptin levels are elevated even in obese patients. This is contrary to earlier suggestions that obesity was the result of a leptin deficiency. The failure of elevated leptin levels to alter the obese state of these individuals may instead be related to a "leptin resistance" and an inability of leptin to enter the cerebral spinal fluid to reach receptors in the hypothalamus. Circulating leptin is also believed to be bound to a carrier protein. Whether this is a unique binding protein or represents a form of the leptin receptor remains unclear. However, this carrier protein may be an important regulator and may explain rapid changes in serum leptin levels that occur as a result of starvation or forced feeding.

Leptin may also play a role in other endocrine processes, including adaptation to starvation and the onset of puberty [6]. Recent studies have suggested that leptin is also produced by the human placenta indicating a role for leptin related to reproductive function [4].

  1. Blum WF, et al. J. Clin. Endocrinol. Metab. 82: 2904, 1997.
  2. Pelleymounter MA, et al. Science 269: 540-543, 1995.
  3. Gura T. Science 275: 751-753, 1997.
  4. Tritos NA. & Mantzoros CS. Diabetologia 40: 1371-1379, 1997.
  5. Considine RV, et al. N Engl J Med. 334: 292-295, 1996.
  6. Flier JS. Proc Natl Acad Sci USA. 94: 4242-4245, 1997.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Leptin ELISA Test
2. Leptin IRMA Test
3. Leptin
4. Gama-GT Soluble Reagent
5. Soluble Fibrin Monomer
6. Soluble Liver Antigen Antibody, IgG
7. Soluble Transferrin Receptor
8. TSH Receptor (TSHR) Autoantibody Coated-Tube (CT)
9. TSH Receptor (TSHR) Autoantibody - ELISA
10. TSH Receptor (TSHR) Autoantibody - RIA
11. Acetylcholine Receptor (AChR) Binding Autoantibody RIA
ArcticTemp Upright Freezer -20C. Quick, even freezing. Heavy duty compressor. Deep door racks. Front gated bottom shelf. Interior light. Locks One year warranty on unit and 5 year warranty on compres...
... 240 is a basic portable system for ... results can be obtained when used with ... electrode. • Fast and easy one- and ... for five buffers (pH 1.68, 4.00, 7.00, ...
... 3 swing doors, 12 shelves. Over-sized compressor. ... Fluorescent interior lighting. Self-Contained System No plumbing ... Full One Year Warranty on Parts & ... Compressor. Also available as a chromatography ...
... doors, 8 shelves. Over-sized compressor. ... Fluorescent interior lighting. Self-Contained System No plumbing ... Full One Year Warranty on Parts & ... Compressor. Also available as a chromatography ...
Medicine Products:
(Date:5/26/2016)... ... 26, 2016 , ... Intalere, the healthcare industry leader in ... inaugural Member Conference at the Paris Hotel in Las Vegas, Nev., May 17-20, ... America’s healthcare providers. , The conference was highlighted by the announcement of the ...
(Date:5/26/2016)... ... 26, 2016 , ... The Woodlands at John Knox Village , Florida’s ... care for living and healing, celebrated its grand opening, today. The Woodlands at John ... provided by Empowered Staff. , “This is an incredibly fulfilling time for John Knox ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... development solutions for drugs, biologics, consumer health and global clinical supply services, today ... Korea to support the company’s continued investment and strategic growth plans in the ...
(Date:5/26/2016)... ... May 26, 2016 , ... Memorial Day Weekend marks the unofficial ... is sharing tips to make sure your family and vehicle are ready to ... Council, there may be 439 deaths and an additional 50,500 serious injuries from motor ...
(Date:5/26/2016)... ... 26, 2016 , ... North Cypress Medical Center hosted its 9th ... Cypress. With the help of community partners, the event organizers raised $45,000 for the ... wounded service members and their families through health, wellness, and therapeutic support. , ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25,2016 FDA ... near-infrared Cellvizio platform for urological and surgical applications ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... milestone in the US with the 12 th ... Drug Administration (FDA). This new FDA clearance covers ...
(Date:5/25/2016)... , Germany and GERMANTOWN, ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... licensing and co-development agreement with Therawis Diagnostics GmbH to develop ... be to develop and market PITX2 as a marker to ... high-risk breast cancer patients. "We are pleased to ...
(Date:5/25/2016)... -- According to market research "Global Insulin ... Forecast to 2022 - Industry Insights by Type (Insulin ... P&S Market Research, the global insulin delivery device market ... is expected to grow at a CAGR of 6.6% ... is expected to witness the fastest growth at a ...
Breaking Medicine Technology: