Navigation Links
Leptin Soluble Receptor ELISA Test

ProductsLeptin Soluble Receptor ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Leptin Soluble Receptor ELISA Test
Features Inquire
Description Leptin is a 16kDa peptide encoded by the ob gene and is produced exclusively by adipocytes. It is believed to play a key role in the regulation of body weight by influencing energy intake and expenditure [1,2]. Leptin functions as a lipostat and is produced by adipocytes in response to increasing fat stores. Increased serum leptin levels signal the brain to stop eating and increase energy expenditure. Conversely, declining fat stores result in reduced leptin secretion which signals the brain to counteract weight loss by increasing feed intake and decreasing energy expenditure [3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism provided by leptin to the brain is necessary for the precise regulation of long term energy balance [4]. Leptin expression and levels are consistently associated with body adiposity and body mass index (BMI) [4]. In humans, leptin levels are elevated with increasing adiposity in both men and women [5]. A relationship between serum leptin levels and several measures of adiposity demonstrates that leptin levels are elevated even in obese patients. This is contrary to earlier suggestions that obesity was the result of a leptin deficiency. The failure of elevated leptin levels to alter the obese state of these individuals may instead be related to a "leptin resistance" and an inability of leptin to enter the cerebral spinal fluid to reach receptors in the hypothalamus. Circulating leptin is also believed to be bound to a carrier protein. Whether this is a unique binding protein or represents a form of the leptin receptor remains unclear. However, this carrier protein may be an important regulator and may explain rapid changes in serum leptin levels that occur as a result of starvation or forced feeding.

Leptin may also play a role in other endocrine processes, including adaptation to starvation and the onset of puberty [6]. Recent studies have suggested that leptin is also produced by the human placenta indicating a role for leptin related to reproductive function [4].

  1. Blum WF, et al. J. Clin. Endocrinol. Metab. 82: 2904, 1997.
  2. Pelleymounter MA, et al. Science 269: 540-543, 1995.
  3. Gura T. Science 275: 751-753, 1997.
  4. Tritos NA. & Mantzoros CS. Diabetologia 40: 1371-1379, 1997.
  5. Considine RV, et al. N Engl J Med. 334: 292-295, 1996.
  6. Flier JS. Proc Natl Acad Sci USA. 94: 4242-4245, 1997.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Leptin ELISA Test
2. Leptin IRMA Test
3. Leptin
4. Gama-GT Soluble Reagent
5. Soluble Fibrin Monomer
6. Soluble Liver Antigen Antibody, IgG
7. Soluble Transferrin Receptor
8. TSH Receptor (TSHR) Autoantibody Coated-Tube (CT)
9. TSH Receptor (TSHR) Autoantibody - ELISA
10. TSH Receptor (TSHR) Autoantibody - RIA
11. Acetylcholine Receptor (AChR) Binding Autoantibody RIA
... is designed to augment areas ... midface, including the inferior orbital ... in the hollow under the ... implant aids in restoring the ...
Flattened points in vertical plane, straight shafts, cross action, round handle....
Karate chopper, spear shaped for ease of insertion into the nucleus....
Round serrated handle, dull finish....
Medicine Products:
(Date:6/27/2016)... ... June 27, 2016 , ... A ... revolutionize the emergency ambulance transport experience for the millions of people who require ... has disrupted the taxi industry through the use of technology. Now, SmartEMS has ...
(Date:6/26/2016)... ... 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... videos a whole new perspective by using the title layers in ProSlice Levels ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... Pharma News Issue 52" report to their offering. ... in influenza treatment creates a favourable commercial environment for MedImmune ... growing patient base that will serve to drive considerable growth ... vaccine would serve to cap sales considerably, but development is ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
Breaking Medicine Technology: