Navigation Links
Leptin Soluble Receptor ELISA Test

ProductsLeptin Soluble Receptor ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Leptin Soluble Receptor ELISA Test
Features Inquire
Description Leptin is a 16kDa peptide encoded by the ob gene and is produced exclusively by adipocytes. It is believed to play a key role in the regulation of body weight by influencing energy intake and expenditure [1,2]. Leptin functions as a lipostat and is produced by adipocytes in response to increasing fat stores. Increased serum leptin levels signal the brain to stop eating and increase energy expenditure. Conversely, declining fat stores result in reduced leptin secretion which signals the brain to counteract weight loss by increasing feed intake and decreasing energy expenditure [3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism provided by leptin to the brain is necessary for the precise regulation of long term energy balance [4]. Leptin expression and levels are consistently associated with body adiposity and body mass index (BMI) [4]. In humans, leptin levels are elevated with increasing adiposity in both men and women [5]. A relationship between serum leptin levels and several measures of adiposity demonstrates that leptin levels are elevated even in obese patients. This is contrary to earlier suggestions that obesity was the result of a leptin deficiency. The failure of elevated leptin levels to alter the obese state of these individuals may instead be related to a "leptin resistance" and an inability of leptin to enter the cerebral spinal fluid to reach receptors in the hypothalamus. Circulating leptin is also believed to be bound to a carrier protein. Whether this is a unique binding protein or represents a form of the leptin receptor remains unclear. However, this carrier protein may be an important regulator and may explain rapid changes in serum leptin levels that occur as a result of starvation or forced feeding.

Leptin may also play a role in other endocrine processes, including adaptation to starvation and the onset of puberty [6]. Recent studies have suggested that leptin is also produced by the human placenta indicating a role for leptin related to reproductive function [4].

  1. Blum WF, et al. J. Clin. Endocrinol. Metab. 82: 2904, 1997.
  2. Pelleymounter MA, et al. Science 269: 540-543, 1995.
  3. Gura T. Science 275: 751-753, 1997.
  4. Tritos NA. & Mantzoros CS. Diabetologia 40: 1371-1379, 1997.
  5. Considine RV, et al. N Engl J Med. 334: 292-295, 1996.
  6. Flier JS. Proc Natl Acad Sci USA. 94: 4242-4245, 1997.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Leptin ELISA Test
2. Leptin IRMA Test
3. Leptin
4. Gama-GT Soluble Reagent
5. Soluble Fibrin Monomer
6. Soluble Liver Antigen Antibody, IgG
7. Soluble Transferrin Receptor
8. TSH Receptor (TSHR) Autoantibody Coated-Tube (CT)
9. TSH Receptor (TSHR) Autoantibody - ELISA
10. TSH Receptor (TSHR) Autoantibody - RIA
11. Acetylcholine Receptor (AChR) Binding Autoantibody RIA
Sensitive Eyes sterile saline spray is the preservative-free aerosol saline solution for people with eyes sensitive to preservatives. Used for rinsing soft contact lenses after cleaning or thermal or...
Ultrazyme enzymatic cleaner works in a single step, taking as little as 15 minutes for cleaning....
... specialty Eraser instruments have been designed ... the right tool for situations requiring ... series of 25 gauge intraocular, bipolar, ... treatment of target tissues for fine-tip ...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 5/box....
Medicine Products:
(Date:4/24/2017)... ... April 24, 2017 , ... Miami ... attending the 2017 Oral Reconstruction Foundation’s 2017 Symposium on Tissue Regeneration and Implant ... will present its annual Global Symposium at the Fontainebleau Hotel located in Miami ...
(Date:4/24/2017)... ... April 24, 2017 , ... Anaconda BioMed, ... neuro-thrombectomy systems for the treatment of Acute Ischemic Stroke (AIS), today announced it ... as the product advances towards regulatory and clinical phases. , "This is another ...
(Date:4/23/2017)... ... April 23, 2017 , ... Altura ... the achievement of Cisco Select certification and SMB specialization. Altura is now ... , In earning the Select Certification, Altura fulfilled the training and exam ...
(Date:4/22/2017)... ... April 22, 2017 , ... PharmacyChecker.com released its first ... average of 70% when buying medication online from Canadian pharmacies verified in the ... from other countries. The report (chart below) compares U.S. and foreign prices for ...
(Date:4/21/2017)... ... April 21, 2017 , ... An April 10 article in the ... which reveal a great deal about prehistoric ice-age dental practitioners and their primitive and, ... used to remove decayed dental matter, and that teeth were then filled with bitumen, ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Inc ., a digital health company focused on modernizing and ... $25 million in Series B funding led by Qiming US ... Seattle that is part of a broader family ... included participation from SR One , who led ZappRx,s ... Google Ventures). As part of the financing, Mark McDade ...
(Date:4/20/2017)... Research and Markets has announced the ... Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies ... ... was valued at US$ 7,167.6 Mn in 2015, and is ... a CAGR of 5.6% from 2016 to 2024. ...
(Date:4/20/2017)... 20, 2017 NeuroVive Pharmaceutical AB (Nasdaq ... positive preclinical results demonstrating anti-fibrotic effects with ... steatohepatitis (NASH), in an additional well-validated experimental ... has previously shown similar anti-fibrotic effects in ... scientists present novel data demonstrating anti-fibrotic effects ...
Breaking Medicine Technology: