Navigation Links
Leptin Soluble Receptor ELISA Test

ProductsLeptin Soluble Receptor ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Leptin Soluble Receptor ELISA Test
Features Inquire
Description Leptin is a 16kDa peptide encoded by the ob gene and is produced exclusively by adipocytes. It is believed to play a key role in the regulation of body weight by influencing energy intake and expenditure [1,2]. Leptin functions as a lipostat and is produced by adipocytes in response to increasing fat stores. Increased serum leptin levels signal the brain to stop eating and increase energy expenditure. Conversely, declining fat stores result in reduced leptin secretion which signals the brain to counteract weight loss by increasing feed intake and decreasing energy expenditure [3]. Leptin operates at the level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism provided by leptin to the brain is necessary for the precise regulation of long term energy balance [4]. Leptin expression and levels are consistently associated with body adiposity and body mass index (BMI) [4]. In humans, leptin levels are elevated with increasing adiposity in both men and women [5]. A relationship between serum leptin levels and several measures of adiposity demonstrates that leptin levels are elevated even in obese patients. This is contrary to earlier suggestions that obesity was the result of a leptin deficiency. The failure of elevated leptin levels to alter the obese state of these individuals may instead be related to a "leptin resistance" and an inability of leptin to enter the cerebral spinal fluid to reach receptors in the hypothalamus. Circulating leptin is also believed to be bound to a carrier protein. Whether this is a unique binding protein or represents a form of the leptin receptor remains unclear. However, this carrier protein may be an important regulator and may explain rapid changes in serum leptin levels that occur as a result of starvation or forced feeding.

Leptin may also play a role in other endocrine processes, including adaptation to starvation and the onset of puberty [6]. Recent studies have suggested that leptin is also produced by the human placenta indicating a role for leptin related to reproductive function [4].

  1. Blum WF, et al. J. Clin. Endocrinol. Metab. 82: 2904, 1997.
  2. Pelleymounter MA, et al. Science 269: 540-543, 1995.
  3. Gura T. Science 275: 751-753, 1997.
  4. Tritos NA. & Mantzoros CS. Diabetologia 40: 1371-1379, 1997.
  5. Considine RV, et al. N Engl J Med. 334: 292-295, 1996.
  6. Flier JS. Proc Natl Acad Sci USA. 94: 4242-4245, 1997.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Leptin ELISA Test
2. Leptin IRMA Test
3. Leptin
4. Gama-GT Soluble Reagent
5. Soluble Fibrin Monomer
6. Soluble Liver Antigen Antibody, IgG
7. Soluble Transferrin Receptor
8. TSH Receptor (TSHR) Autoantibody Coated-Tube (CT)
9. TSH Receptor (TSHR) Autoantibody - ELISA
10. TSH Receptor (TSHR) Autoantibody - RIA
11. Acetylcholine Receptor (AChR) Binding Autoantibody RIA
Provides extended cold therapy to the shoulder area for acute, chronic, or post-surgical applications. The DuraKold products can help reduce pain, edema, and speed recovery....
Provides continuous cold therapy to the knee area for acute, chronic, or post-surgical applications. Cryotherapy can reduce pain, swelling and facilitate faster rehabilitation....
... Halo™ was designed in 1988 as an attachment ... patient, it greatly restricts rotation of the cervical ... Halo can be removed while allowing the Collar ... used in conjunction with the Philadelphia Stabilizer attachment., ...
... cold therapy Gel Pad. Our Gel Pad helps ... to reduce swelling and /or hot therapy to ... order hot and cold therapy gel pad, place ... suspenders can be added to each support upon ...
Medicine Products:
(Date:5/26/2017)... Germantown, MD (PRWEB) , ... May 26, 2017 , ... ... the anti-stress Antzy Top gadget will continue to be available at a discounted crowdfunding ... people deal with stress wherever they are, I also wanted to bring a fidget ...
(Date:5/26/2017)... Francisco, CA (PRWEB) , ... May 26, 2017 , ... ... Francisco, is proud to announce a new, informational blog post on insurance options. If ... surgery, checking insurance plans may help save time and money. Visiting an in-network provider ...
(Date:5/26/2017)... ... , ... “Just What Happened in the Garden of Eden”: retells the stories of three Bible ... creation of published author, Penelope Colt, mother, trader, horse farmer, artist and a former GM ... was three. At six, they moved to Dayton, Ohio, where Penny graduated high school. ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... background. Understanind and choosing the most appropriate instruments for research and understanding the ... research finding. This webinar will focus on innovations in stereo microscopy for brightfield ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas ... who have now spent 10 years as clinical instructors for the reputable Full ... of Dentistry. Through the program, private practitioners receive cutting-edge clinical training and learn ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... Texas , May 5, 2017   Provista , ... with more than 200,000 customers, today announced Jim Cunniff ... a wealth of executive and business experience to Provista, including ... compounding pharmacy in California . He assumed ... "Jim is a great fit for Provista," says ...
(Date:5/4/2017)... 2017 Clarius Mobile Health, a digital ... scanners this week at the American Congress of ... San Diego, CA from ... the perfect tool for clinicians to easily confirm ... evaluate pregnancy-related complications like ectopic pregnancy and placenta ...
(Date:5/3/2017)... 2017 A Catheterization Laboratory is an ... facility. Commonly referred to as cath lab, this ... imaging technology to give physicians visual access to ... spaces, a team of physicians perform life-saving procedures ... intervention, congenital heart defect closure, stenotic heart valves, ...
Breaking Medicine Technology: