Navigation Links
Leptin IRMA Test

ProductsLeptin IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Leptin IRMA Test
Features Inquire
Description Leptin is a proteohormone with a molecular weight of 16 kDa. Leptin is a protein encoded by the ob gene and produced by adipocytes [1,2]. Leptin is thought to play a key role in the regulation of body weight [1-3]. In the human, leptin levels are elevated with increasing adiposity in both men and women [4]. A relationship between serum leptin levels and several measures of adiposity (e.g. body mass index (BMI) or percent body fat) demonstrates that leptin levels are elevated even in obese patients. The failure of these elevated leptin levels to alter the obese state of these individuals may be related to a leptin resistance and an inability of leptin to enter the cerebral spinal fluid to reach sites in the hypothalamus to regulate appetite. Involvement of a leptin receptor or carrier protein in this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short term, the long-term administration both in vivo and in vitro indicates that these two hormones may be some of the major regulators of leptin production by adipose tissue. Without an understanding of leptin regulation and how to circumvent leptin resistance, the use of leptin to treat the obese individual remains a question for future research. Leptin levels have been shown to change under certain endocrine conditions. For example when leptin levels are expressed per body adiposity, females have higher leptin levels than do males. This may be related to the distribution of adipose tissue where omental fat vs. subcutaneous fat, which differs between gender, may have different leptin production rates. The nature of circulating leptin has not been fully explored but the suggestion that it is bound to a circulating protein has been presented. Whether this is a separate protein or represents a circulating form of the leptin receptor remains to be investigated but this may be an important form of regulation to explain rapid changes in serum leptin levels that may occur. Some examples of rapid changes in leptin levels would be starvation and forced feeding where changes within 24 to 48 hours are readily observed in serum leptin concentrations. Similarly, there are rapid declines postpartum suggesting that something other than the amount of adipose tissue may regulate circulating levels of leptin. Many areas of leptin physiology remain to be investigated. Leptins role in metabolism, insulin sensitivity, as a potential therapeutic modality for weight loss as well as its involvement in endocrine function are active areas of research. While the future for leptin as a therapeutic agent is not clear, its involvement in many areas of physiology undoubtedly makes this a new hormone which will require extensive study in the next few years to understand its physiology.

  1. Blum WF., Englaro P., Hanitsch s., et. al.: Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage, and Testosterone. J Clin Endoc and Metab. 82: 2904, 1997.
  2. Harigaya A., Nagashima K., Nako Y., and Morikawa A.: Relationship Between Concentration of Serum Leptin and Fetal Growth. J Clin. Endoc. and Metab. 82. 3281, 1997
  3. Pelleymounter, MA, et al.: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995.
  4. Considine RV, et al.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:292-295, 1996.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Leptin ELISA Test
2. Leptin Soluble Receptor ELISA Test
3. Leptin
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products:
(Date:5/23/2013)... (PRWEB) May 23, 2013 Verndale, ... announce the launch of Current Digital, a business ... development and digital marketing needs. Companies now view ... strategic business necessity. This can often leave agencies ... strategy on preselected software platforms that they may ...
(Date:5/23/2013)... Worldwide Power Products (WPP), a power-generation equipment provider ... the rights to sell Hythane Company's OptiBlend™ ... mixture of natural gas and diesel. WPP will offer ... sale and rental and will also sell retrofitting services ... technicians will be certified to install the conversion kits ...
(Date:5/23/2013)... 23, 2013 According to the ... one cause of death in America today and is the ... More than 400,000 women die in the United States each ... minute. Seven factors are considered to profile the status of ... list. Many people are under the false assumption that if ...
(Date:5/23/2013)... 23, 2013 The Assault Hand ... a major milestone in its corporate development. After ... the release of the Assault Hand Paddle is an ... The Assault Hand Paddle is “revolutionizing paddle sportsmen’s stealth ... paddle sportsmen seeking stealth and close quarter mobility. ...
(Date:5/23/2013)... With crowded gyms, bodyweight workouts and ... to Mike Whitfield, a bodyweight expert in the Atlanta, ... medicine ball can add a whole new dynamic to ... website in which anyone can download a 4-week bodyweight ... he shared a video with his subscribers showing the ...
Breaking Medicine News(10 mins):Health News:Verndale Launches Current Digital, a Technology Partner for Ad and Creative Agencies 2Health News:Verndale Launches Current Digital, a Technology Partner for Ad and Creative Agencies 3Health News:Worldwide Power Products Announces Partnership with Hythane Company to Offer OptiBlend™ Bi-Fuel Solution for Diesel Engines 2Health News:Worldwide Power Products Announces Partnership with Hythane Company to Offer OptiBlend™ Bi-Fuel Solution for Diesel Engines 3Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Safe and Healthy New Fast Weight Loss Alternative for At-Risk Heart Disease Patients 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Safe and Healthy New Fast Weight Loss Alternative for At-Risk Heart Disease Patients 3Health News:The Assault Hand Paddle Revolution is On 2Health News:The Assault Hand Paddle Revolution is On 3Health News:Unique Ab Exercise, the Medicine Ball Chop, Released from BodyweightTorch.com 2
... the children’s hospital Boston, a surgery was conducted on a baby ... stent procedure in the womb. // She was discharged on Friday ... was diagnosed with a heart defect called hypoplastic left heart syndrome ... placed a stent in the developing fetus on November 7, 2005. ...
... in a hospital at Brisbane a patient had to be ... attacked and was in serious condition, attention could not be ... Hospital, where emergency services are scarce due to shortage of ... operational from 8am to 6pm every day. ,The ...
... largest drug maker, Pfizer has announced that it intends to ... regulatory approvals from the US Food and Drug Administration ... been developed in collaboration with Sanofi-Aventis and Nektar Therapeutics. ... that no needles or pens or syringes are needed. "Until ...
... Robert Hill, a Crohn’s patient has successfully reached the ... climb began // on January 12th and was successfully ... and sub-freezing temperatures. ,He was a strong, ... and ulcerative colitis. During the course of the disease ...
... of stress on the pregnant women. ... stress and people are in search for a remedy for it. // ... number of pregnant women approaching the health care centers for a treatment ... a need to include new information about the management of stress during ...
... Cyprus are reported to be infected with the H5N1 strain, ... European Union country, even though the EU rules remain suspended ... where the infection was detected attracts as many as 1 ... the virus is said to be the same that claimed ...
Cached Medicine News:Health News:Baby Underwent A Heart Surgery Inside The Womb 2Health News:Crohn's Patient Robert Hill’s greatest achievemen 2
(Date:5/22/2013)... 2013  Aribex, Inc., manufacturer of the newly released ... new color option, black with gray trim, of the ... markets. The popular white with light blue trim Pro ... be available and both models can be purchased from ... http://photos.prnewswire.com/prnh/20130522/CL19573 ) "Dental offices are adding ...
(Date:5/22/2013)... , May 22, 2013 Attorney ... potential claims on behalf of purchasers of the ... "Company") (NasdaqGS: AMAG -News).  The investigation focuses on ... securities laws. On May 22, 2013, ... intraday trading after the company announced in regulatory ...
(Date:5/22/2013)... and CAESAREA, Israel , May 22, ... New clinical data presented from the DEFLECT-I study demonstrates ... reduces brain lesion volume during TAVR (Transcatheter Aortic Valve ... Keystone Heart Scientific Advisory Board announces consensus on the ... regarding the importance and need for cerebral protection during ...
Breaking Medicine Technology:Aribex Unveils New Color of NOMAD Pro 2 2Bronstein, Gewirtz & Grossman, LLC Announces Investigation of AMAG Pharmaceuticals, Inc. 2New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 2New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 3New Clinical Data Presented at EuroPCR Demonstrates that TriGuard Reduces Brain Lesion Volume during TAVR 4