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Insulin RIA Test

ProductsInsulin RIA Test
Company Diagnostic Systems Laboratories, Inc.
Item Insulin RIA Test
Description Insulin is the only physiologic hormone which significantly lowers blood glucose levels. In response to a number of stimuli, including glucose and amino acids, insulin is secreted into the hepatic portal circulation [1,2]. Although 50% of the insulin is removed initially by the liver, the remainder enters the general circulation and is carried to other target tissues. Insulin then binds to specific cell-surface receptors [3] and facilitates substrate uptake and intracellular utilization, resulting in net increases in intracellular lipid, protein and glycogen [1,2,3,4]. Insulin is rapidly cleared both by liver uptake, tissue utilization and renal clearance and circulating insulin levels are very low during fasting. Elevated serum fasting insulin levels with normal or elevated glucose concentrations are characteristic of the insulin-resistant forms of glucose intolerance and diabetes mellitus, as well as other insulin resistant conditions [5,6,7]. Conversely, low insulin concentrations in the presence of hyperglycemia suggests insulin-deficiency (e.g. insulin-dependent or Type I diabetes mellitus). Measurement of immediate or first-phase insulin secretion after an acute glucose load may be predictive of Type I diabetes mellitus [8,9].

  1. Gerich JE: Hormonal control of homeostasis. IN Galloway JA, Potvin JH, Shuman CR (eds): Diabetes Mellitus, ninth edition. Eli Lilly Co, Indianapolis, 1988, pp 46-63.
  2. Rasmussen H, et al. Diab Care 13:655-666, 1990.
  3. Gammeltoft S. Physiol Rev 64:1321-1378, 1984.
  4. Rosen OM. Science 237:1452-1458, 1987.
  5. Bjrntorp P. Diab Care 14:1132 - 1143, 1991.
  6. ORahilly S & Moller DE. Clin Endocrinol 36:121-132, 1992.
  7. Reaven GM. Diab care 14:195-202, 1991.
  8. Chase HP, et al. J Pediatr 111:807-812, 1987.
  9. Robert J-J, et al. Diab Care 14:718-723, 1991.
Info Diagnostic Systems Laboratories, Inc.
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