|Products||Insulin RIA Test|
|Company||Diagnostic Systems Laboratories, Inc.|
|Item||Insulin RIA Test|
|Description|| Insulin is the only physiologic hormone which significantly lowers blood glucose levels. In response to a number of stimuli, including glucose and amino acids, insulin is secreted into the hepatic portal circulation [1,2]. Although 50% of the insulin is removed initially by the liver, the remainder enters the general circulation and is carried to other target tissues. Insulin then binds to specific cell-surface receptors  and facilitates substrate uptake and intracellular utilization, resulting in net increases in intracellular lipid, protein and glycogen [1,2,3,4]. Insulin is rapidly cleared both by liver uptake, tissue utilization and renal clearance and circulating insulin levels are very low during fasting. Elevated serum fasting insulin levels with normal or elevated glucose concentrations are characteristic of the insulin-resistant forms of glucose intolerance and diabetes mellitus, as well as other insulin resistant conditions [5,6,7]. Conversely, low insulin concentrations in the presence of hyperglycemia suggests insulin-deficiency (e.g. insulin-dependent or Type I diabetes mellitus). Measurement of immediate or first-phase insulin secretion after an acute glucose load may be predictive of Type I diabetes mellitus [8,9].
|Info|| Diagnostic Systems Laboratories, Inc.|
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Web site: http://www.dslabs.com