Navigation Links

ProductsIGFBP-4 ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Features Inquire
Description Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein which specifically binds and modulates the actions of IGF-I and IGF-II. It is also present in a glycoslyated form with a molecular weight of 28 kDa. IGFBP-4 has been identified in all biological fluids, as well as in numerous cell types, including fibroblasts, neuroblastoma, prostate and bone cells [1,2]. IGFBP-4 appears to be inhibitory to IGF action by binding the IGFs and preventing their interaction with the IGF receptors [1]. This inhibitory function of IGFBP-4 is protease dependent [2]. The regulatory mechanisms that control IGFBP-4 expression are still poorly understood, however in bone IGFBP-4 appears to be regulated by PTH and 1,25 dihydroxyvitamin D3 [2]. Serum levels of IGFBP-4 appear to increase with age. In elderly women, this increase appears to be due in part to the age-related increase in PTH production of which is stimulated in calcium deficiency states [3].

  1. Cohen P & Rosenfeld RG. Current Opinion in Pediatrics. 6: 462-467, 1994
  2. Collett-Solberg PF & Cohen P. The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action IN Rosenfield RL (ed) Growth and Growth Disorders. WB Saunders Company, Philadelphia, vol. 25, no. 3, pp 591-614, 1996
  3. Rajaram S, et al. Endocrine Reviews. 18(6): 801-831, 1997
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site:

Related medicine products :

1. Microplate ELISA Washers - Manual Microplate Washer
2. Microplate ELISA Washers - Automated Microplate Washer
3. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
4. RELISA ANA Screening System
5. BioCheck hCG ELISA
6. Human Chorionic Gonadotropin (HCG) ELISA Kit
7. Human PSA ELISA Kit
8. Total PSA ELISA Test
10. PAP Microwell ELISA
11. Trinity Biotech Captia™ B. burgdorferi IgG/IgM ELISA
... and Respiratory Products, ,Westmed designs, manufacturers ... Anesthesia and Respiratory professionals. Our mission is ... the clinician's ability to deliver quality medical ... bottom line. , ,Our web site ...
... compressor. This high output compressor can shorten ... to the patient's lungs. When combined with ... STAR® Reusable Nebulizer, the particle size of ... into the lungs. With less medication wasted, ...
... The new PARI TREK™ Compact Compressor ... take their aerosol treatments anywhere and everywhere. ... powerful. Three versatile power source optionsworldwide AC ... and rechargeable battery, permit patients the freedom ...
... Compressed Air., ,Allied Healthcares Timeter® PCS 414 ... other air compressors that you may wonder if ... PCS 414 features a durable, mar-resistant steel case ... unit weighs only 26.5 pounds. The PCS 414 ...
Medicine Products:
(Date:11/25/2015)... BROOK, Ill. (PRWEB) , ... November 25, 2015 ... ... larger and potentially more aggressive than those found on mammography, according to a ... MRI findings of additional cancers not seen on mammography may necessitate a change ...
(Date:11/25/2015)... ... 2015 , ... As part of a global movement to ... together who want to combine talents and resources to help create sustainable communities ... The non-profit launched its first major fundraiser on November 6, 2015 at Bent ...
(Date:11/25/2015)... ... November 25, 2015 , ... The holiday season ... and pleasing the palates of attendees is of the utmost importance. Whether you ... seasonal get-together, give these recipes a try this holiday season. , Turkey Croquettes ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in ... on several models of traditional and far-infrared saunas. , For traditional saunas, ... the most traditional Finnish sauna wood, and Finnleo uses only European Grade A Nordic ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... has been recognized once again for its stellar workplace culture with the company’s ... , Medical Solutions’ Cincinnati office was named a finalist in Cincinnati ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015 Allergan plc (NYSE: ... and Rugen Therapeutics, a start-up  biotechnology company focused ... CNS disorders and funded by the F-Prime Biomedical ... entered into an exclusive collaboration to support the ... Spectrum Disorders (ASD) and Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... 25, 2015 USP 800 applies to ... (e.g. pharmacists, pharmacy technicians, nurses, physicians, physician assistants, ... chapter also covers all entities which store, prepare, ... other healthcare institutions, patient treatment clinics, physicians, practice ... --> What is the purpose ...
(Date:11/25/2015)... Asia -based venture ... and the New Investors will make a direct equity ... private placement. The financing will help IOPtima to continue ... in the treatment of glaucoma, as well as to ... system with the U.S. Food and Drug Administration, commencing ...
Breaking Medicine Technology: