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IGFBP-4 ELISA Test

ProductsIGFBP-4 ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-4 ELISA Test
Features Inquire
Description Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein which specifically binds and modulates the actions of IGF-I and IGF-II. It is also present in a glycoslyated form with a molecular weight of 28 kDa. IGFBP-4 has been identified in all biological fluids, as well as in numerous cell types, including fibroblasts, neuroblastoma, prostate and bone cells [1,2]. IGFBP-4 appears to be inhibitory to IGF action by binding the IGFs and preventing their interaction with the IGF receptors [1]. This inhibitory function of IGFBP-4 is protease dependent [2]. The regulatory mechanisms that control IGFBP-4 expression are still poorly understood, however in bone IGFBP-4 appears to be regulated by PTH and 1,25 dihydroxyvitamin D3 [2]. Serum levels of IGFBP-4 appear to increase with age. In elderly women, this increase appears to be due in part to the age-related increase in PTH production of which is stimulated in calcium deficiency states [3].

  1. Cohen P & Rosenfeld RG. Current Opinion in Pediatrics. 6: 462-467, 1994
  2. Collett-Solberg PF & Cohen P. The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action IN Rosenfield RL (ed) Growth and Growth Disorders. WB Saunders Company, Philadelphia, vol. 25, no. 3, pp 591-614, 1996
  3. Rajaram S, et al. Endocrine Reviews. 18(6): 801-831, 1997
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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