Navigation Links

ProductsIGFBP-4 ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Features Inquire
Description Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein which specifically binds and modulates the actions of IGF-I and IGF-II. It is also present in a glycoslyated form with a molecular weight of 28 kDa. IGFBP-4 has been identified in all biological fluids, as well as in numerous cell types, including fibroblasts, neuroblastoma, prostate and bone cells [1,2]. IGFBP-4 appears to be inhibitory to IGF action by binding the IGFs and preventing their interaction with the IGF receptors [1]. This inhibitory function of IGFBP-4 is protease dependent [2]. The regulatory mechanisms that control IGFBP-4 expression are still poorly understood, however in bone IGFBP-4 appears to be regulated by PTH and 1,25 dihydroxyvitamin D3 [2]. Serum levels of IGFBP-4 appear to increase with age. In elderly women, this increase appears to be due in part to the age-related increase in PTH production of which is stimulated in calcium deficiency states [3].

  1. Cohen P & Rosenfeld RG. Current Opinion in Pediatrics. 6: 462-467, 1994
  2. Collett-Solberg PF & Cohen P. The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action IN Rosenfield RL (ed) Growth and Growth Disorders. WB Saunders Company, Philadelphia, vol. 25, no. 3, pp 591-614, 1996
  3. Rajaram S, et al. Endocrine Reviews. 18(6): 801-831, 1997
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site:

Related medicine products :

1. Microplate ELISA Washers - Manual Microplate Washer
2. Microplate ELISA Washers - Automated Microplate Washer
3. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
4. RELISA ANA Screening System
5. BioCheck hCG ELISA
6. Human Chorionic Gonadotropin (HCG) ELISA Kit
7. Human PSA ELISA Kit
8. Total PSA ELISA Test
10. PAP Microwell ELISA
11. Trinity Biotech Captia™ B. burgdorferi IgG/IgM ELISA
... The PiGalileo™ Computer-Assisted ... from PLUS Orthopedics ... technology and electro-mechanical ... to assist the ...
... TOX/See™ is a 1-step, hand-held, point-of-care device ... metabolites in human urine. The TOX/See device ... commonly abused drugs in 3 to 8 minutes ... Each TOX/See cassette is individually packaged to maximize ...
... a 1-step, hand-held, point-of-care device for the qualitative ... urine. The TOX/See device can detect up ... in 3 to 8 minutes and requires only ... is individually packaged to maximize convenience and ease ...
... TOX/See™ is a 1-step, hand-held, point-of-care device ... metabolites in human urine. The TOX/See device ... commonly abused drugs in 3 to 8 minutes ... Each TOX/See cassette is individually packaged to maximize ...
Medicine Products:
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: