Navigation Links
IGFBP-3 IRMA Test

ProductsIGFBP-3 IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-3 IRMA Test
Features 
Description Human Insulin-like growth factor binding protein-3 (IGFBP-3) is the main binding protein for IGF-I and IGF-II in postnatal serum, as a component of the ~150 kDa ternary complex. This complex consists of IGFBP-3, a molecule of IGF-I or IGF-II and ALS, allowing IGFBP-3, along with ALS, to regulate the actions of the IGFs. The molar concentration of IGFBP-3 in normal serum is proportional to the molar concentration of total IGFs (i.e. IGF-I + IGF-II) [1]. In addition, total IGF levels show higher correlation with GH in circulation than either IGF-I or IGF-II levels alone [2]. IGFBP-3 is GH-dependent, however IGFBP-3 may be less age-dependent than IGF-I [3]. These aspects of IGFBP-3 physiology allow its measurement to reflect GH activity. Thus, in GH deficiency of either pituitary or hypothalamic origin, IGFBP-3 levels are uniformly low. Blum et al. [3] reported that 128/132 children with GH deficiency had serum IGFBP-3 concentrations below the 5th percentile for age. In situations of GH receptor deficiency, such as Laron syndrome, anti-GH antibodies, liver disease or malnutrition, IGFBP-3 levels are also reduced, even in the presence of elevated serum GH concentrations [4]. Measurement of IGFBP-3 levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders.

  1. Baxter R & Martin J. J Clin Invest 78:1504-12, 1986.
  2. Powell DR, et al. J Clin Endocrinol Metab 63:1186-1192, 1986.
  3. Blum WF, et al. J Clin Endocrinol Metab 70:1292-8, 1990.
  4. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76: 417-423, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IMMULITE/IMMULITE 1000 IGFBP-3
2. IMMULITE 2000 IGFBP-3
3. IGFBP-3
4. IGFBP-3 ELISA Test
Provides the security of suture and ease of automated knot tying for vascular closure of 5-8F....
... all-new Canon CF-60DSi is an all-digital Fundus camera ... and an efficient workflow. The ... The Canon EOS-1Ds series SLR digital camera features ... mega pixel resolution and the new ICG unit, ...
... Aumated Immunoassay Analyzer that fits in any lab ... 16 X 16 X 21 inches and weighs ... ideal for physician office laboratories, work stations for ... as well as a dedicated system for specialty ...
... one, help physicians serve their patients. ,By ... is provided with significantly useful details regarding ... accomplishment is combined with dedicated clinical applications ... features: High Resolution Analog ...
Medicine Products:
(Date:1/19/2017)... ... January 19, 2017 , ... "ProParagraph ... will simplify the editing process for all media productions," said Christina Austin - ... of 30 simplistically styled self-animating paragraphs designed for multi-lined text purposes. Choose ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... College of Proctology) announced today the opening of 3 medical offices specializing ... ): Hemorrhoids Center of Los Angeles (Beverly Hills), Hemorrhoids Center of Newport ...
(Date:1/18/2017)... ... January 18, 2017 , ... Delaware farmer Rick Dickerson attended ... Missouri. , Dickerson, of Laurel, farms about a thousand acres of soybeans, corn and ... on contract and pumpkins and other vegetables for the fresh market. He also operates ...
(Date:1/18/2017)... ... January 18, 2017 , ... The VA Maryland Health ... on a research project focused on multiple sclerosis (MS). Led by Christopher M. ... to control the disease without compromising normal immune function that often occurs during ...
(Date:1/18/2017)... NC (PRWEB) , ... January 18, 2017 , ... The ... remain on Team V, its official endurance training and fundraising team, to compete in ... V Foundation welcomes those inspired to finish the world’s oldest annual marathon to join ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 18, 2017 , , Marks E-QURE ... rd distribution agreement, following similar agreements in ... Wound care is $2 5 ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the ... Tech - Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia ...
(Date:1/19/2017)... , Jan. 18, 2017 The Global Therapy ... and access to partnering deals and agreements entered into ... in partnering deals - Top deals by value - ... development, technology type The report provides understanding and ... by the world,s leading healthcare companies. The report ...
(Date:1/19/2017)... , Jan. 18, 2017   Synthetic ... clinical company developing therapeutics designed to preserve the ... patients, today confirmed plans to initiate a Phase ... modified-release reformulation of lovastatin lactone designed to reduce ... in the gut to treat the underlying ...
Breaking Medicine Technology: