Navigation Links
IGFBP-3 IRMA Test

ProductsIGFBP-3 IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-3 IRMA Test
Features 
Description Human Insulin-like growth factor binding protein-3 (IGFBP-3) is the main binding protein for IGF-I and IGF-II in postnatal serum, as a component of the ~150 kDa ternary complex. This complex consists of IGFBP-3, a molecule of IGF-I or IGF-II and ALS, allowing IGFBP-3, along with ALS, to regulate the actions of the IGFs. The molar concentration of IGFBP-3 in normal serum is proportional to the molar concentration of total IGFs (i.e. IGF-I + IGF-II) [1]. In addition, total IGF levels show higher correlation with GH in circulation than either IGF-I or IGF-II levels alone [2]. IGFBP-3 is GH-dependent, however IGFBP-3 may be less age-dependent than IGF-I [3]. These aspects of IGFBP-3 physiology allow its measurement to reflect GH activity. Thus, in GH deficiency of either pituitary or hypothalamic origin, IGFBP-3 levels are uniformly low. Blum et al. [3] reported that 128/132 children with GH deficiency had serum IGFBP-3 concentrations below the 5th percentile for age. In situations of GH receptor deficiency, such as Laron syndrome, anti-GH antibodies, liver disease or malnutrition, IGFBP-3 levels are also reduced, even in the presence of elevated serum GH concentrations [4]. Measurement of IGFBP-3 levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders.

  1. Baxter R & Martin J. J Clin Invest 78:1504-12, 1986.
  2. Powell DR, et al. J Clin Endocrinol Metab 63:1186-1192, 1986.
  3. Blum WF, et al. J Clin Endocrinol Metab 70:1292-8, 1990.
  4. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76: 417-423, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IMMULITE/IMMULITE 1000 IGFBP-3
2. IMMULITE 2000 IGFBP-3
3. IGFBP-3
4. IGFBP-3 ELISA Test
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products:
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Halo Labs announces the European launch ... called the HORIZON at MIBio 2017 in Cambridge, U.K ... visible particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity ... novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017 ... mobile health and big data solutions, today announced that its MyDario product ... check your local TV listings for when The Dr. Oz Show airs ... The ... this month. ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology: