Navigation Links
IGFBP-3 IRMA Test

ProductsIGFBP-3 IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-3 IRMA Test
Features 
Description Human Insulin-like growth factor binding protein-3 (IGFBP-3) is the main binding protein for IGF-I and IGF-II in postnatal serum, as a component of the ~150 kDa ternary complex. This complex consists of IGFBP-3, a molecule of IGF-I or IGF-II and ALS, allowing IGFBP-3, along with ALS, to regulate the actions of the IGFs. The molar concentration of IGFBP-3 in normal serum is proportional to the molar concentration of total IGFs (i.e. IGF-I + IGF-II) [1]. In addition, total IGF levels show higher correlation with GH in circulation than either IGF-I or IGF-II levels alone [2]. IGFBP-3 is GH-dependent, however IGFBP-3 may be less age-dependent than IGF-I [3]. These aspects of IGFBP-3 physiology allow its measurement to reflect GH activity. Thus, in GH deficiency of either pituitary or hypothalamic origin, IGFBP-3 levels are uniformly low. Blum et al. [3] reported that 128/132 children with GH deficiency had serum IGFBP-3 concentrations below the 5th percentile for age. In situations of GH receptor deficiency, such as Laron syndrome, anti-GH antibodies, liver disease or malnutrition, IGFBP-3 levels are also reduced, even in the presence of elevated serum GH concentrations [4]. Measurement of IGFBP-3 levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders.

  1. Baxter R & Martin J. J Clin Invest 78:1504-12, 1986.
  2. Powell DR, et al. J Clin Endocrinol Metab 63:1186-1192, 1986.
  3. Blum WF, et al. J Clin Endocrinol Metab 70:1292-8, 1990.
  4. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76: 417-423, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IMMULITE/IMMULITE 1000 IGFBP-3
2. IMMULITE 2000 IGFBP-3
3. IGFBP-3
4. IGFBP-3 ELISA Test
... 20cm x 20cm. System transfers ... quickly. The stainless steel cathode and ... free. These electrodes create a uniform ... available in 35cm x 45cm format. ...
... from agarose gels to hybridization membranes in ... and efficiency of transfer by allowing high ... of an integrated system allowing electrophoresis, gel ... hours, versus 29 hours required for conventional ...
... Transfers depurinated DNA and RNA from ... little as 15 minutes ,Increases speed and ... to be applied to gel ,Part of ... transfer and UV crosslinking in 2.5 hours, ...
PosiBlot 30-30 Pads...
Medicine Products:
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: