Navigation Links
IGFBP-3 ELISA Test

ProductsIGFBP-3 ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-3 ELISA Test
Features 
Description Human Insulin-like growth factor binding protein-3 (IGFBP-3) is the main binding protein for IGF-I and IGF-II in postnatal serum, as a component of the ~150 kDa ternary complex. This complex consists of IGFBP-3, a molecule of IGF-I or IGF-II and ALS, allowing IGFBP-3, along with ALS, to regulate the actions of the IGFs. The molar concentration of IGFBP-3 in normal serum is proportional to the molar concentration of total IGFs (i.e. IGF-I + IGF-II) [1]. In addition, total IGF levels show higher correlation with GH in circulation than either IGF-I or IGF-II levels alone [2]. IGFBP-3 is GH-dependent, however IGFBP-3 may be less age-dependent than IGF-I [3]. These aspects of IGFBP-3 physiology allow its measurement to reflect GH activity. Thus, in GH deficiency of either pituitary or hypothalamic origin, IGFBP-3 levels are uniformly low. Blum et al. [3] reported that 128/132 children with GH deficiency had serum IGFBP-3 concentrations below the 5th percentile for age. In situations of GH receptor deficiency, such as Laron syndrome, anti-GH antibodies, liver disease or malnutrition, IGFBP-3 levels are also reduced, even in the presence of elevated serum GH concentrations [4]. Measurement of IGFBP-3 levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders.

  1. Baxter R & Martin J. J Clin Invest 78:1504-12, 1986.
  2. Powell DR, et al. J Clin Endocrinol Metab 63:1186-1192, 1986.
  3. Blum WF, et al. J Clin Endocrinol Metab 70:1292-8, 1990.
  4. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76: 417-423, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IMMULITE/IMMULITE 1000 IGFBP-3
2. IMMULITE 2000 IGFBP-3
3. IGFBP-3
4. IGFBP-3 IRMA Test
5. Microplate ELISA Washers - Manual Microplate Washer
6. Microplate ELISA Washers - Automated Microplate Washer
7. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
8. RELISA ANA Screening System
9. BioCheck hCG ELISA
10. Human Chorionic Gonadotropin (HCG) ELISA Kit
11. Human PSA ELISA Kit
Topics include: ECG reading, ACLS (all the latest protocols and pearls), CHF, acute MI, cardiac testing, palpitations, pericarditis, arrhythmias, murmurs, athletes, valvular disease, endocarditis, sy...
Cardiology Core Curriculum fills the gap between the preclinical pathophysiology texts and specialist volumes aimed at cardiologists. It covers clinical cardiology for medical students, cardiology tr...
... published by Unbound Medicine ... resource that combines evidence-based ... edge technology. It offers ... specifically engineered to provide ...
This electronic survival guide provides all the essential information that every surgery intern needs from Day 1 on the wards....
Medicine Products:
(Date:9/20/2017)... ... September 20, 2017 , ... FirstAlign ( ... with the latest Artificial Intelligence (AI) thinking, announced today the launch of its ... access to essential information that offers a more comprehensive understanding of the organization’s ...
(Date:9/20/2017)... Lexington, Massachusetts (PRWEB) , ... ... ... Corporation , a software company specializing in medical device compliance and commercialization, ... engineering in risk management activities. , FDA is more adamant than ever ...
(Date:9/20/2017)... ... , ... Compliancy Group is proud to announce that its ... another long-time client pass their Department of Health and Human Services (HHS) Office ... to the help of the Compliancy Group's Audit Response Program™, not a single ...
(Date:9/20/2017)... VA (PRWEB) , ... September 20, 2017 , ... The ... (IPPS) 2018 Final Rule that it will transition to using only Worksheet S-10 to ... Join the first of three live 60-minute complimentary webinars on October 17, ...
(Date:9/20/2017)... ... 20, 2017 , ... “RECYCLED Ezekiel's Plan for Freedom from ... from ADDICTION” is the creation of published author, Bill Miller. Bill Miller ... services, including more than a decade of addiction to prescription drugs. He ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 6, 2017  Robert G. Szewc, M.D., is recognized ... in recognition of his contributions to the Medical field.  ... Nephrologist at the practice of Kidney and Hypertension Specialists, ... and hypertension solutions. He has worked in this position ... experience, as well as expertise in kidneys, hypertension, chronic ...
(Date:9/6/2017)... WILMINGTON, Del. , Sept. 6, 2017 NeuroRx, ... for Acute Suicidal Ideation and Behavior (ASIB), has been granted ... for its sequential therapy of NRX-100 (ketamine HCl) followed by ... patients in a pivotal trial of this sequential therapy targeting ... bipolar depression. 1 ...
(Date:9/5/2017)... , Sept. 5, 2017  Xyntek Inc. has announced another milestone in their ... Midwest office to meet the growing demands of customer engagements regionally.  ... Xyntek's new Midwest office is located at 318 West Adams ... ... engagements regionally. ...
Breaking Medicine Technology: