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ProductsIGFBP-2 ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Features Inquire
Description Human Insulin-like growth factor binding protein-2 (IGFBP-2) is one of six characterized IGFBPs (further IGFBPs have been proposed) which specifically bind and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I [1], suggesting a role in regulation of IGF-II action. Studies in the fetal sheep indicate that IGFBP-2 is produced in many tissues, apparently coincident with IGF-II expression [2]. Recent studies of serum IGFBP-2 levels have shown that, unlike for IGFBP-1, there is negligible variability during the day [1] and, unlike IGFBP-1 and IGFBP-3, virtually no change during puberty [3]. IGFBP-2 has also been identified in other body fluids such as cerebrospinal [4], amniotic and coelomic fluids [5], urine [6] and seminal fluid [7].

  1. Rechler M. Vit Horm 47:1-114, 1993.
  2. Delhanty PJD & Han VKM. Endocrinology 132:41-52, 1993.
  3. Juul A, et al. J Clin Endocrinol Metab 78: 744-52, 1994.
  4. Muller HL, et al. J Clin Endocrinol Metab 79:428-434, 1994.
  5. Chard T, et al. J Endocrinol 142:379-383, 1994.
  6. Gargosky SE, et al. J Clin Endocrinol Metab 76:1631-1637, 1993.
  7. Rosenfeld RG, et al. J Clin Endocrinol Metab 70:551-553, 1990
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
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