Navigation Links
IGFBP-1, Total IRMA Test

ProductsIGFBP-1, Total IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-1, Total IRMA Test
Features Inquire
Description Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 may be involved in glucose regulation and IGF-mediated substrate utilization [1,2]. IGFBP-1 has been shown to inhibit [3,4] as well as augment [5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefore, its capacity to modulate their cellular responsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture media have been reported [7-11]. Non-phosphorylated IGFBP-1 has been shown to have 4- to 6-fold lower affinity for IGF-I compared with phosphorylated IGFBP-1 variants [7,9]. IGFBP-1 levels are inversely related to insulin concentrations and are not correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations.

  1. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993.
  2. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991.
  3. Lewitt MS, et al. Endocrinology 124:2254-2256, 1991.
  4. Liu L, et al. Biochem Biophys Res Commun. 174:673-679, 1991.
  5. Eglin RG, et al. Proc Natl Acad Sci USA 84:3254-3258.
  6. Busby WH, et al. Endocrinology 125:7481-7485, 1989.
  7. Jones JI, et al. Proc Natl Acad Sci USA 88:7481-7485, 1991.
  8. Frost RA & Tseng L. J Biol Chem 266:18082-18088, 1991.
  9. Jones JI, et al. J Biol Chem 268:1125-1131, 1993.
  10. Koistinen R, et al. Clinica Chemica Acta 215:189-199, 1993.
  11. Westwood M, et al. J Clin Endocrinol Metab 70:1735-1741, 1994.
  12. Conover CA, et al. Diabetes 39:1251-1256, 1990.
  13. Lee PDK, et al. Metabolism 42:409-414, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGFBP-1, Total ELISA Test
2. Laserex Tango M (Total Mobile Version)
3. Bilirubin, Direct & Total
4. Bilirubin Total Reagent
5. Total Bilirubin Reagent
6. Total Protein
7. Total Protein Reagent
8. Total Protein Reagent Set
9. Iron Total (TIBC)
10. Iron (Total/Ferene)
11. Cholesterol, Total
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products:
(Date:9/3/2015)... Lawrenceville, Georgia (PRWEB) , ... September 03, 2015 ... ... the spread of disease in Haiti, has partnered with Slingshot® Product Development Group ... no electricity or running water. Michael Wahl with DriButts plans to bring 600 ...
(Date:9/3/2015)... ... ... Real Time Pain Relief (RTPR), makers of the popular rub-on pain ... an official endorsement deal with the company. Originally from New South Wales, Australia, Mason ... 15. He is an Australian bull riding champion, following in his uncles’ footsteps in ...
(Date:9/3/2015)... Tamarac, FL (PRWEB) , ... September 03, 2015 ... ... of the Florida Companies to Watch for 2015 by economic development ... one of only 50 companies in the state selected for this prestigious award, ...
(Date:9/3/2015)... , ... September 03, 2015 , ... ... estate investment landscape by connecting accredited and institutional investors to real estate investment ... products designed to meet demand from both investors and sponsoring real estate companies. ...
(Date:9/3/2015)... ... ... Girl’s Night Out to benefit Core Compassion Project will be held on ... Monroe, North Carolina. The event food will be provided by Kate Clyde's ... off-premise catering and event services from casual to elegant. They are also the home ...
Breaking Medicine News(10 mins):Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Real Time Pain Relief Sponsors the Talented PBR Bull Rider from Down Under - David Mason 2Health News:Real Time Pain Relief Sponsors the Talented PBR Bull Rider from Down Under - David Mason 3Health News:IQ Formulations Hailed Among Florida Companies to Watch for 2015 2Health News:IQ Formulations Hailed Among Florida Companies to Watch for 2015 3Health News:RealtyShares Announces Mezzanine Financing Products 2Health News:RealtyShares Announces Mezzanine Financing Products 3Health News:Girl’s Night Out, with Food From Kate Clyde's Catered Creations, to Benefit Core Compassion Project 2
... stray cancer cells lurking elsewhere in the body that otherwise ... study in the June 13 issue of the journal ... most may have such indolent cancer cells given the sheer ... them impossible to detect, the researchers said. , The ...
... his famous poem, "Do not go gentle into that good ... dying of the light." Researchers are now backing up this ... to one,s health is critical to good health and survival ... the notion that one should become actively involved in one,s ...
... Pharmaceuticals, Inc. (NASDAQ: MIPI) announced today that it ... its Trofex molecular imaging program for the detection ... is designed to investigate two small molecule radiopharmaceutical ... and MIP-1095, in order to select a lead ...
... Foundation, a,nonprofit organization that funds research in early ... five recipients of its Canary,Foundation and American Cancer ... during Canary Foundation,s Early,Detection Symposium in May, the ... of fellows sponsored since the program,s inception in,2004. ...
... supports Courage Center Camps, MINNEAPOLIS, June 12 The ... 2008, at the St. Cloud Country Club. Golfers,will enjoy a ... a,great cause -- Courage Center,s Camp Courage., Registration and ... 1 p.m.,Cost per golfer is $150 or $600 for a ...
... and Life Sciences Customers the DICOM ... EMC Select, ST. PAUL, Minn., June 12 ... grid software for,intelligent medical image management, DICOM and storage ... announced that its DICOM,Services Grid is now available through ...
Cached Medicine News:Health News:Primary tumors can drive the growth of distant cancers 2Health News:Primary tumors can drive the growth of distant cancers 3Health News:Study pinpoints strategies that protect older adult's physical health 2Health News:Molecular insight begins Trofex Ph. 1 trial for detection of metastatic prostate cancer 2Health News:Canary Foundation and American Cancer Society Award Five Postdoctoral Fellowships in Early Cancer Detection 2Health News:Canary Foundation and American Cancer Society Award Five Postdoctoral Fellowships in Early Cancer Detection 3Health News:Canary Foundation and American Cancer Society Award Five Postdoctoral Fellowships in Early Cancer Detection 4Health News:DICOM Services Grid(TM) From Acuo Technologies(R) Available Through EMC Select 2
(Date:9/3/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/lnn7ss/investigation ) has ... on China,s Levothyroxine Market, 2010-2019" report to ... have the greatest effect of promoting growth on ... mainly promote the growth and development of bones, ... (GH) of pipuitary gland can,t work. Besides, pipuitary ...
(Date:9/3/2015)... Sep. 03, 2015 Research ... of the "Investigation Report on China,s Bromhexine Market, ... air pollution worsens, the incidence of respiratory disease keeps ... drugs. Bromhexine, a semisynthetic derivative of vasicine, is a ... and asthma associated with viscid or excessive mucus. It ...
(Date:9/3/2015)... , September 3, 2015 ... subsidiary Lupin Pharmaceuticals, Inc. (Lupin) has launched its ... the first and only generic Duloxetine formulation to ... is excited to bring this new strength to ... dosing options for greater flexibility of treatment. ...
Breaking Medicine Technology:Investigation Report on China's Levothyroxine Market, 2010-2019 2China Bromhexine Market Report 2015-2019 2Lupin Launches First-ever Duloxetine 40mg Delayed-Release Capsules in the US 2Lupin Launches First-ever Duloxetine 40mg Delayed-Release Capsules in the US 3Lupin Launches First-ever Duloxetine 40mg Delayed-Release Capsules in the US 4