Navigation Links
IGFBP-1, Total IRMA Test

ProductsIGFBP-1, Total IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-1, Total IRMA Test
Features Inquire
Description Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 may be involved in glucose regulation and IGF-mediated substrate utilization [1,2]. IGFBP-1 has been shown to inhibit [3,4] as well as augment [5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefore, its capacity to modulate their cellular responsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture media have been reported [7-11]. Non-phosphorylated IGFBP-1 has been shown to have 4- to 6-fold lower affinity for IGF-I compared with phosphorylated IGFBP-1 variants [7,9]. IGFBP-1 levels are inversely related to insulin concentrations and are not correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations.

  1. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993.
  2. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991.
  3. Lewitt MS, et al. Endocrinology 124:2254-2256, 1991.
  4. Liu L, et al. Biochem Biophys Res Commun. 174:673-679, 1991.
  5. Eglin RG, et al. Proc Natl Acad Sci USA 84:3254-3258.
  6. Busby WH, et al. Endocrinology 125:7481-7485, 1989.
  7. Jones JI, et al. Proc Natl Acad Sci USA 88:7481-7485, 1991.
  8. Frost RA & Tseng L. J Biol Chem 266:18082-18088, 1991.
  9. Jones JI, et al. J Biol Chem 268:1125-1131, 1993.
  10. Koistinen R, et al. Clinica Chemica Acta 215:189-199, 1993.
  11. Westwood M, et al. J Clin Endocrinol Metab 70:1735-1741, 1994.
  12. Conover CA, et al. Diabetes 39:1251-1256, 1990.
  13. Lee PDK, et al. Metabolism 42:409-414, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGFBP-1, Total ELISA Test
2. Laserex Tango M (Total Mobile Version)
3. Bilirubin, Direct & Total
4. Bilirubin Total Reagent
5. Total Bilirubin Reagent
6. Total Protein
7. Total Protein Reagent
8. Total Protein Reagent Set
9. Iron Total (TIBC)
10. Iron (Total/Ferene)
11. Cholesterol, Total
The SurLok helical stone baskets are constructed of strong and resilient stainless steel. These helical baskets present a spiral profile that effectively clears both stones and fragments....
It is available in a 5cc-balloon version with round tip and two opposing eyes, and a 30cc-balloon version with two staggered eyes. BARDEX Silicone-Elastomer Foley Catheters are also available in kits...
All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Intended for one-time use....
The BARDEX I.C. Catheter represents Bard's newest technology in providing protection against NUTI....
Medicine Products:
(Date:2/23/2017)... ... February 23, 2017 , ... CALNOC, the nation’s first and only ... their upcoming conference – Empowerment, Value and Collaboration – in Seattle, WA on October ... the Virginia Mason Health System in Seattle since 2000. In addition to his role ...
(Date:2/23/2017)... ... February 23, 2017 , ... Curemark, LLC announced today that the Blüm ... in children aged 3-8 with Autism, is now enrolling at three new sites. These ... the United States. , “There are currently no approved drugs that address the ...
(Date:2/23/2017)... ... 23, 2017 , ... Thomas Vas-Don suffered from severe injury due ... was able to successfully recover. In “ Origin & Insertion Charts for Massage Therapists ... the principals of massage, anatomy , trigger points and referral pain patterns ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... and lobby of a new healthcare contact center in Georgia, PENETRON Specialty Products ... of the nation’s largest healthcare systems recently invested $51 million to purchase and ...
(Date:2/22/2017)... ... 22, 2017 , ... Gevir, a New Zealand-based company that focuses on developing ... coming soon to Amazon.com, the world’s largest online retailer. , The company ... an effective natural treatment for Shelley’s Multiple Sclerosis, which she’d been diagnosed with at ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 23, 2017 Tillotts Pharma is ... Berlin office was opened in January ... The portfolio includes Entocort ® for the treatment ... of ulcerative colitis, and VistaPrep ® for bowel ... specialty pharmaceutical company focused on the treatment of gastrointestinal ...
(Date:2/23/2017)... MabVax Therapeutics Holdings, Inc . ... announces that it has received notice from the ... initiation a Phase I clinical trial with MVT-1075 ... ( 177 Lu-CHX-A?-DTPA-HuMab5B1) is the Company,s novel fully ... the phase I clinical trial in patients with ...
(Date:2/23/2017)... 2017 Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT) ( ... and dermatology biopharmaceutical company, today announced that it has ... as special advisers to the Company,s Board of ... board on financial and corporate strategy. Provectus ... of up to $2.5 million from Eric Wachter ...
Breaking Medicine Technology: