Navigation Links
IGFBP-1, Total IRMA Test

ProductsIGFBP-1, Total IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-1, Total IRMA Test
Features Inquire
Description Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 may be involved in glucose regulation and IGF-mediated substrate utilization [1,2]. IGFBP-1 has been shown to inhibit [3,4] as well as augment [5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefore, its capacity to modulate their cellular responsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture media have been reported [7-11]. Non-phosphorylated IGFBP-1 has been shown to have 4- to 6-fold lower affinity for IGF-I compared with phosphorylated IGFBP-1 variants [7,9]. IGFBP-1 levels are inversely related to insulin concentrations and are not correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations.

  1. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993.
  2. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991.
  3. Lewitt MS, et al. Endocrinology 124:2254-2256, 1991.
  4. Liu L, et al. Biochem Biophys Res Commun. 174:673-679, 1991.
  5. Eglin RG, et al. Proc Natl Acad Sci USA 84:3254-3258.
  6. Busby WH, et al. Endocrinology 125:7481-7485, 1989.
  7. Jones JI, et al. Proc Natl Acad Sci USA 88:7481-7485, 1991.
  8. Frost RA & Tseng L. J Biol Chem 266:18082-18088, 1991.
  9. Jones JI, et al. J Biol Chem 268:1125-1131, 1993.
  10. Koistinen R, et al. Clinica Chemica Acta 215:189-199, 1993.
  11. Westwood M, et al. J Clin Endocrinol Metab 70:1735-1741, 1994.
  12. Conover CA, et al. Diabetes 39:1251-1256, 1990.
  13. Lee PDK, et al. Metabolism 42:409-414, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGFBP-1, Total ELISA Test
2. Laserex Tango M (Total Mobile Version)
3. Bilirubin, Direct & Total
4. Bilirubin Total Reagent
5. Total Bilirubin Reagent
6. Total Protein
7. Total Protein Reagent
8. Total Protein Reagent Set
9. Iron Total (TIBC)
10. Iron (Total/Ferene)
11. Cholesterol, Total
The S7 Lightweight offers the comfort and reliability of the award-winning S7 series in a convenient, affordable device....
... This unit offers a ... humidification controls. It also has ... and accurate. Its session meter ... that last more than four ...
... flexibility with the integrated Everest system. ... the system will be functional for ... an integrated heated humidifier. The Everest ... one nights use, and the reservoir ...
Low-taper wall construction guarantees error less than 1% absolute, 0.4 hematocrit, relative...
Medicine Products:
(Date:5/23/2016)... ... May 23, 2016 , ... California State University Northridge ... quality of life and is currently focusing on ways to improve how people ... tested through research to find out whether watching them could have a significant ...
(Date:5/23/2016)... ... 2016 , ... During Logan University’s (Logan) Spring ... awarded $6,000 in chiropractic scholarships. The winners of the three $2,000 scholarships ... fifth trimester of classes at Logan. , “Standard Process has been extremely generous ...
(Date:5/23/2016)... ... May 23, 2016 , ... Hospice of Westchester (HOW), ... for over 24 years, recently hosted its sixth annual Celebration of Life Memorial ... remembrance ceremonies, each concluding with the release of Monarch butterflies that honored the ...
(Date:5/23/2016)... ... 23, 2016 , ... Bio-Optronics, Inc. is delighted to announce ... its recent and anticipated growth. , Max Elbaz was appointed as Vice President, ... segments. Max joined the Bio-Optronics team in March. His areas of expertise include ...
(Date:5/23/2016)... ... May 23, 2016 , ... While new ... epidemic (1), physicians are not legally required to follow them. In the absence ... 3, 4). Novus Medical Detox Center , a leading Florida-based drug treatment ...
Breaking Medicine News(10 mins):
(Date:5/19/2016)... 2016 , The data will be ... # 8006)   The conclusions of the study ... treated patients with 90% of the m presenting ... . Seventy two percent of the patients had clinical benefit. ... results from a Phase I study of plitidepsin in combination with bortezomib and ...
(Date:5/19/2016)... , May 19, 2016 ... titled, World Biopsy Devices Market Opportunities and Forecasts, ... devices market generated $1,621 million in 2015. The ... 2015, and is expected to maintain this trend ... http://photos.prnewswire.com/prnh/20140911/647229 ) , To ...
(Date:5/19/2016)... 19, 2016 MGB Biopharma, ... of Anti-infectives, Welcomes the Final Instalment of Lord ... Today   Lord Jim O,Neill,s ... final recommendations, providing a comprehensive action plan for ... the rising threat of superbugs - something that ...
Breaking Medicine Technology: