Navigation Links
IGFBP-1, Total ELISA Test

ProductsIGFBP-1, Total ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-1, Total ELISA Test
Features Inquire
Description Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 may be involved in glucose regulation and IGF-mediated substrate utilization [1,2]. IGFBP-1 has been shown to inhibit [3,4] as well as augment [5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefore, its capacity to modulate their cellular responsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture media have been reported [7-11]. Non-phosphorylated IGFBP-1 has been shown to have 4- to 6-fold lower affinity for IGF-I compared with phosphorylated IGFBP-1 variants [7,9]. IGFBP-1 levels are inversely related to insulin concentrations and are not correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations.

  1. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993.
  2. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991.
  3. Lewitt MS, et al. Endocrinology 124:2254-2256, 1991.
  4. Liu L, et al. Biochem Biophys Res Commun. 174:673-679, 1991.
  5. Eglin RG, et al. Proc Natl Acad Sci USA 84:3254-3258.
  6. Busby WH, et al. Endocrinology 125:7481-7485, 1989.
  7. Jones JI, et al. Proc Natl Acad Sci USA 88:7481-7485, 1991.
  8. Frost RA & Tseng L. J Biol Chem 266:18082-18088, 1991.
  9. Jones JI, et al. J Biol Chem 268:1125-1131, 1993.
  10. Koistinen R, et al. Clinica Chemica Acta 215:189-199, 1993.
  11. Westwood M, et al. J Clin Endocrinol Metab 70:1735-1741, 1994.
  12. Conover CA, et al. Diabetes 39:1251-1256, 1990.
  13. Lee PDK, et al. Metabolism 42:409-414, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGFBP-1, Total IRMA Test
2. Laserex Tango M (Total Mobile Version)
3. Bilirubin, Direct & Total
4. Bilirubin Total Reagent
5. Total Bilirubin Reagent
6. Total Protein
7. Total Protein Reagent
8. Total Protein Reagent Set
9. Iron Total (TIBC)
10. Iron (Total/Ferene)
11. Cholesterol, Total
Used to introduce large balloon, closed and non-tapered end catheters or other devices for intervention....
Used for contralateral access to the iliac artery for interventional procedures after initial wire guide positioning has been established.,NOTE: Use of a heavy-duty wire guide is recommended....
Sheath Introducers with guidewires....
... Driver Stent design, utilizing an ... limitations of stainless steel stents. ... thinner struts, for unparalleled flexibility ... Driver Coronary Stent Systemwith thin ...
Medicine Products:
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Venture Construction ... Classic Tournament held on June 20th at the Woodmont Country Club at 1201 ... Wings, an organization dedicated to helping service members that have been wounded in battle ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: