Navigation Links
IGFBP-1, Total ELISA Test

ProductsIGFBP-1, Total ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-1, Total ELISA Test
Features Inquire
Description Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 may be involved in glucose regulation and IGF-mediated substrate utilization [1,2]. IGFBP-1 has been shown to inhibit [3,4] as well as augment [5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefore, its capacity to modulate their cellular responsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture media have been reported [7-11]. Non-phosphorylated IGFBP-1 has been shown to have 4- to 6-fold lower affinity for IGF-I compared with phosphorylated IGFBP-1 variants [7,9]. IGFBP-1 levels are inversely related to insulin concentrations and are not correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations.

  1. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993.
  2. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991.
  3. Lewitt MS, et al. Endocrinology 124:2254-2256, 1991.
  4. Liu L, et al. Biochem Biophys Res Commun. 174:673-679, 1991.
  5. Eglin RG, et al. Proc Natl Acad Sci USA 84:3254-3258.
  6. Busby WH, et al. Endocrinology 125:7481-7485, 1989.
  7. Jones JI, et al. Proc Natl Acad Sci USA 88:7481-7485, 1991.
  8. Frost RA & Tseng L. J Biol Chem 266:18082-18088, 1991.
  9. Jones JI, et al. J Biol Chem 268:1125-1131, 1993.
  10. Koistinen R, et al. Clinica Chemica Acta 215:189-199, 1993.
  11. Westwood M, et al. J Clin Endocrinol Metab 70:1735-1741, 1994.
  12. Conover CA, et al. Diabetes 39:1251-1256, 1990.
  13. Lee PDK, et al. Metabolism 42:409-414, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGFBP-1, Total IRMA Test
2. Laserex Tango M (Total Mobile Version)
3. Bilirubin, Direct & Total
4. Bilirubin Total Reagent
5. Total Bilirubin Reagent
6. Total Protein
7. Total Protein Reagent
8. Total Protein Reagent Set
9. Iron Total (TIBC)
10. Iron (Total/Ferene)
11. Cholesterol, Total
For the qualitative detection of group A streptococcal antigen from throat swabs....
For the qualitative detection of group A Streptococcal antigen from throat swabs...
For the qualitative detection of human Chorionic Gonadotrophin (hCG) in urine specimens...
For the qualitative detection of human Chorionic Gonadotrophin (HCG) in urine or urine and serum specimens...
Medicine Products:
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
Breaking Medicine Technology: