Navigation Links
IGFBP-1, Total ELISA Test

ProductsIGFBP-1, Total ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGFBP-1, Total ELISA Test
Features Inquire
Description Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests that IGFBP-1 may be involved in glucose regulation and IGF-mediated substrate utilization [1,2]. IGFBP-1 has been shown to inhibit [3,4] as well as augment [5,6] IGF bioactivity. These paradoxical reports may be due to differential phosphorylation of IGFBP-1 which may significantly alter its affinity for IGFs and, therefore, its capacity to modulate their cellular responsiveness. As many as five IGFBP-1 variants, differing in their state of phosphorylation and relative expression in serum, amniotic fluid, decidua and cell culture media have been reported [7-11]. Non-phosphorylated IGFBP-1 has been shown to have 4- to 6-fold lower affinity for IGF-I compared with phosphorylated IGFBP-1 variants [7,9]. IGFBP-1 levels are inversely related to insulin concentrations and are not correlated with growth hormone or glucose levels [12,13]. Subsequently, measurement of IGFBP-1 levels may be useful as a marker of insulin action and hepatocyte function for research investigations.

  1. Lee PDK, et al. Proc Soc Exp Biol Med 204:4-29, 1993.
  2. Holly JMP. Acta Endocrinol 124 (supp 2): 55-62, 1991.
  3. Lewitt MS, et al. Endocrinology 124:2254-2256, 1991.
  4. Liu L, et al. Biochem Biophys Res Commun. 174:673-679, 1991.
  5. Eglin RG, et al. Proc Natl Acad Sci USA 84:3254-3258.
  6. Busby WH, et al. Endocrinology 125:7481-7485, 1989.
  7. Jones JI, et al. Proc Natl Acad Sci USA 88:7481-7485, 1991.
  8. Frost RA & Tseng L. J Biol Chem 266:18082-18088, 1991.
  9. Jones JI, et al. J Biol Chem 268:1125-1131, 1993.
  10. Koistinen R, et al. Clinica Chemica Acta 215:189-199, 1993.
  11. Westwood M, et al. J Clin Endocrinol Metab 70:1735-1741, 1994.
  12. Conover CA, et al. Diabetes 39:1251-1256, 1990.
  13. Lee PDK, et al. Metabolism 42:409-414, 1993.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGFBP-1, Total IRMA Test
2. Laserex Tango M (Total Mobile Version)
3. Bilirubin, Direct & Total
4. Bilirubin Total Reagent
5. Total Bilirubin Reagent
6. Total Protein
7. Total Protein Reagent
8. Total Protein Reagent Set
9. Iron Total (TIBC)
10. Iron (Total/Ferene)
11. Cholesterol, Total
... Western Blot Kits provide a sensitive and ... Borrelia burgdorferi. Proteins from the spirochete are ... antigens are fractionated according to molecular weight ... in the presence of sodium dodecyl sulfate. ...
Surgitie&trade Single Use Ligating Loops with Delivery System...
Surgitie&trade Single Use Ligating Loops with Delivery System...
ENDO STITCH™ Single Use Loading Units....
Medicine Products:
(Date:9/22/2014)... a very familiar "lub-dub" pattern that speeds up or ... pattern itself isn,t as regular as you might think. ... vary even at a "constant" heart rateand that variability, ... Reduced heart rate variability (HRV) has been found to ... congestive heart failure and inflammation. For athletes, a drop ...
(Date:9/22/2014)... 22, 2014 WHO: LiveOps, Inc., ... customer service solutions. , WHAT: The 10th annual ... customer care for the connected consumer. Constant change ... offer new challenges and opportunities for customer experience ... identify best practices, network and learn from fellow ...
(Date:9/22/2014)... By Tara Haelle ... (HealthDay News) -- Measuring how quickly a child,s brain ... according to a new study. Observing children,s ... is currently possible, the study authors reported. "The ... information is associated with autism severity is hugely promising," ...
(Date:9/22/2014)... CA (PRWEB) September 22, 2014 ... California for a three-day conference to discuss brain-related ... brain injury from concussions and neurodegenerative disorders. ... medical director affiliated with a Silverado memory care ... of dedicated expertise in memory care, hosts the ...
(Date:9/22/2014)... September 22, 2014 The report ... application, end user, and geography. The equipment segment ... physiotherapy equipment market, by product. However, the accessories ... CAGR in the forecast period, owing to the ... Electric stimulation and ultrasound segments are the fastest-growing ...
Breaking Medicine News(10 mins):Health News:Variability keeps the body in balance 2Health News:Variability keeps the body in balance 3Health News:Variability keeps the body in balance 4Health News:LiveOps To Lead Panel Discussion At Customer Response Summit Memphis 2Health News:Brainwaves May Help Gauge Autism Severity: Study 2Health News:Brainwaves May Help Gauge Autism Severity: Study 3Health News:Brainwaves May Help Gauge Autism Severity: Study 4Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 2Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 3Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 2Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 3Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 4Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 5
... offers a low cost, non-invasive alternative to conventional ... having coronary artery disease; true even if the ... a study performed at the Thomas Jefferson University ... patients who had one or more calcified coronary ...
... shown that babies exposed to tobacco in utero are ... are at increased risk for sudden infant death syndrome. ... these babies are also less likely to self-soothe and ... did not smoke during pregnancy. , Researchers from The ...
... the leading,provider of internet and digital information accessibility ... award-winning System Access,software. With this release, Serotek ... support for 64-bit operating systems. This is ... IT professionals,alike. , ...
... ROME, N.Y., Dec. 1 To help prevent the spread ... is using two new,products that kill germs on hands and ... According to Infection Prevention Director LeAnna Grace, the hospital,conducted a ... sanitizing lotion to evaluate how well they work and was ...
... is a statement from Jeff Levi, Ph.D., Executive Director of ... and Drug Administration,s (FDA) progress report on the Food Protection ... lacks a real plan for food protection. The staff ... some key initiatives to improve food safety, but they can ...
... Pressure BioSciences, Inc. (Nasdaq: PBIO ) ("PBI" or ... significantly reduce costs, centralize core operations, and refocus the Company,s ... found significant market acceptance. The restructuring program includes: , ... personnel of eight full-time employees (40% of the workforce) , ...
Cached Medicine News:Health News:Newborns exposed to maternal smoking more irritable, difficult to soothe 2Health News:Serotek First to Offer 64-Bit Support 2Health News:MRSA and C. difficile Infections Reduced by 50% in Hospital Study 2Health News:MRSA and C. difficile Infections Reduced by 50% in Hospital Study 3Health News:TFAH Statement: FDA Food Protection Plan is Insufficient 2Health News:Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus 2Health News:Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus 3Health News:Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus 4Health News:Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus 5Health News:Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus 6Health News:Pressure BioSciences, Inc. Announces Restructuring, Significant Cost Reduction Initiatives, and Sharpened Focus 7
(Date:9/22/2014)... , Sept. 22, 2014  Neuralstem, Inc. (NYSE MKT: ... site investigator at Emory University, presented long-term follow up ... neural stem cells in the treatment of amyotrophic lateral ... presentation, which occurred at the Annual Symposium on ALS ... , on Friday, and was not open to ...
(Date:9/22/2014)... , Sept. 22, 2014  Olympus, a global ... for medical and surgical procedures, among other core ... with Munich -based Brainlab to ... Navigation. This agreement applies to the US ... U.S. sales and all distribution outside the U.S. ...
(Date:9/22/2014)... 22, 2014  Inovio Pharmaceuticals, Inc. (NASDAQ: ... a phase I clinical trial in patients with ... tolerability, and immunogenicity of INO-3106. This immunotherapy targets ... aerodigestive cancers. Aerodigestive cancers affect the ... parts of the esophagus and windpipe. The unmet ...
Breaking Medicine Technology:Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 2Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 3Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 4Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 3Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 4