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IGF-II, w/ Extraction IRMA Test

ProductsIGF-II, w/ Extraction IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGF-II, w/ Extraction IRMA Test
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Description Insulin-like growth factor II (IGF-II) is a 7.5 kDa peptide which is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly carried in blood in the high molecular weight ternary complex with IGFBP-3 and ALS, and a smaller proportion of IGF-II circulates in association with other IGFBPs [4,5]. Serum IGF-II concentrations increase with postnatal age showing a moderate age-related increase throughout childhood and puberty, and there is no significant variability during the day [6,7]. Serum levels of IGF-II are also dependent on GH secretion. IGF-II levels are low in GH deficiency [7], although IGF-II levels may also decrease in GH excess and with exogenous administration of IGF-I [3]. The combined molar concentrations of IGF-I and IGF-II (i.e. Total serum IGF) is proportional to serum IGFBP-3 and consequently may be useful for evaluation of GH-related disorders [8].

  1. Morgan DO, et al. Nature 329:301-307, 1987.
  2. Conover CA, et al. Biochem Biophys Res Commun 139:501-508, 1986.
  3. Gluckman PD & Ambler GR. Mol Cell Endocrinol 92:C1-C3, 1993
  4. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  5. Rechler M. Vit Horm 47:1-114, 1993.
  6. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  7. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  8. Baxter R & Martin J. J Clin Invest 78: 1504-1512, 1986.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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