Navigation Links
IGF-II, w/ Extraction ELISA Test

ProductsIGF-II, w/ Extraction ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGF-II, w/ Extraction ELISA Test
Features Inquire
Description Insulin-like growth factor II (IGF-II) is a 7.5 kDa peptide which is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly carried in blood in the high molecular weight ternary complex with IGFBP-3 and ALS, and a smaller proportion of IGF-II circulates in association with other IGFBPs [4,5]. Serum IGF-II concentrations increase with postnatal age showing a moderate age-related increase throughout childhood and puberty, and there is no significant variability during the day [6,7]. Serum levels of IGF-II are also dependent on GH secretion. IGF-II levels are low in GH deficiency [7], although IGF-II levels may also decrease in GH excess and with exogenous administration of IGF-I [3]. The combined molar concentrations of IGF-I and IGF-II (i.e. Total serum IGF) is proportional to serum IGFBP-3 and consequently may be useful for evaluation of GH-related disorders [8].

  1. Morgan DO, et al. Nature 329:301-307, 1987.
  2. Conover CA, et al. Biochem Biophys Res Commun 139:501-508, 1986.
  3. Gluckman PD & Ambler GR. Mol Cell Endocrinol 92:C1-C3, 1993
  4. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  5. Rechler M. Vit Horm 47:1-114, 1993.
  6. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  7. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  8. Baxter R & Martin J. J Clin Invest 78: 1504-1512, 1986.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGF-II, Non-Extraction ELISA Test
2. IGF-II, Non-Extraction IRMA Test
3. IGF-II, w/ Extraction IRMA Test
4. Lead Extraction System 5
5. Viscous Fluid Injection / Extraction System - 1360/1361
6. IGF-I ELISA Test (Non-Extraction)
7. IGF-I IRMA Test (Non-Extraction)
8. IGF-I ELISA Test (With Extraction)
9. IGF-I IRMA Test (With Extraction)
10. ViralXpress™ DNA/RNA Extraction Reagent
11. Microplate ELISA Washers - Manual Microplate Washer
... The NU-5510 DHD AutoFlow Direct ... HEPA filtration guarantying the greatest control ... cycles, both at 95C wet decontamination ... are exceptionally useful for cell line ...
... upright freezer uses ultra-thin vacuum insulation ... urethane insulation, to increase storage capacity, ... (336) 2" boxes or 3,336 samples. ... reduces energy consumption and extends compressor ...
... Advanced Series CO2 Incubators ... reliability. Microprocessor achieves precise temperature ... natural evaporation & RH% is ... CO2 and RH are displayed ...
... incubator with 6-sided direct heating provides ... lighter-weight incubator with greater internal storage ... HEPA filtered CO2 inlet, heated outer ... fanless, convection air circulation optimize culture ...
Medicine Products:
(Date:7/28/2014)... 28, 2014 (HealthDay News) -- Endurance runners are far ... undetected heart condition, according to a new study. ... in events in warm climates are actually 10 times ... Yet, the less common sudden death of a young ... such as an irregular heartbeat, often gets a lot ...
(Date:7/28/2014)... not divide unless there is enough oxygen present to ... cell types circumvent this rule. Researchers at The Johns ... the cells, warning signals, enabling cancers to continue to ... process, the researchers found that lysosomes the cell,s ... They also uncovered new evidence that certain drugs can ...
(Date:7/28/2014)... 2014 Parker Waichman LLP, a personal injury ... that the heroes of 9/11 are never forgotten, comments that ... important deadline. According to a VCF message dated ... cancer on or before October 12, 2012 must file a ... and others who were allegedly injured by the toxic dust ...
(Date:7/28/2014)... NY (PRWEB) July 28, 2014 The ... organization that has donated more than 200,000 books to ... 2001, announces the launch of Brooke’s Cooks, a new ... while encouraging healthy living among at-risk children and their ... will include a series of nutrition information workshops, cooking ...
(Date:7/28/2014)... July 28, 2014 Bariatric Eating, a ... announced that it will be introducing three additional flavors ... this summer. The additional flavors include: , Inspire Summer ... protein , Inspire Pomegranate Razz Berry -­ Pomegranate, razz ... soft-serve vanilla cone , Bariatric Eating's Inspire protein ...
Breaking Medicine News(10 mins):Health News:Heat Stroke a Greater Threat to Endurance Runners Than Heart Problems: Study 2Health News:Cell's recycling center implicated in division decisions 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2
... Deficit Hyperactivity Disorder (ADHD) is a prevailing issue in ... every year. A new study reveals that Pycnogenol, (pic-noj-en-all), ... French maritime pine tree, reduces ADHD in children. The ... and dopamine, resulting in a decrease of ADHD. ...
... NSERC Idea to Innovations grant and an Ontario Early ... and Nanosystems Laboratory ( http://amnl.mie.utoronto.ca ) at the University ... technology for automated microinjection of zebrafish embryos. , ... microrobotic system is capable of immobilizing a large number ...
... (Sept. 12, 2007) For the first time in ... ocean corals in its annual report of wildlife going ... by Conservation International (CI) and implemented jointly with the ... Charles Darwin Research Station and other regional institutions to ...
... helps teens make better food choices as adults, study finds ... dinner with their families on a regular basis are also ... a new study shows. , These teens also go on ... , Reporting in the Journal of the American Dietetic ...
... Medical,Technologies, Inc. today reported to its board of ... to include England, Canada, New,Zealand and Australia. ... began to come in as a result of ... the ReBuilder System(R). Through,word of mouth and the ...
... may be the last taboo,in our society, a subject that ... to fear -- to be avoided no matter what the ... "Triumph" is the result of daily writing over the ... about Darlyne,s,impending death and Philip,s loss. They have written this ...
Cached Medicine News:Health News:New study: Pine bark extract reduces ADHD symptoms in children 2Health News:Corals added to IUCN Red List of Threatened Species for first time 2Health News:Corals added to IUCN Red List of Threatened Species for first time 3Health News:ReBuilder Medical Technologies, Inc. Reports International Sales Expansion 2Health News:ReBuilder Medical Technologies, Inc. Reports International Sales Expansion 3Health News:ReBuilder Medical Technologies, Inc. Reports International Sales Expansion 4Health News:'Triumph' -- Traveling Towards Death: Preparing for a New Life 2
(Date:7/28/2014)... , July 28, 2014 /PRNewswire-iReach/ -- June 28 th , ... which has developed the AMAS cancer test, is making its ... To date, the test, which is a serum-based in vitro ... emerging as a significant tool in the fight against cancer ... With an estimated 17 million cancer survivors in the ...
(Date:7/28/2014)... , July 28, 2014  Surgical Theater, LLC ... to its Business Advisory Board. New members include ... President for Business Development and New Technologies for ... , former Senior Vice President and General Manager ... Theater applies flight simulation technology to brain surgery ...
(Date:7/28/2014)... , July 28, 2014  VigeneTech, Inc, in ... of LEGENDplex™ Data Analysis Software, an OEM software ... cytometers.  BioLegend develops and offers varieties of bead-based ... With the support of VigeneTech,s data analysis software, ... analyzed and easily reported LEGENDplex™ ...
Breaking Medicine Technology:Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5VigeneTech Releases New Powerful Software for Flow Cytometry Data Analysis 2