Navigation Links
IGF-II, w/ Extraction ELISA Test

ProductsIGF-II, w/ Extraction ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGF-II, w/ Extraction ELISA Test
Features Inquire
Description Insulin-like growth factor II (IGF-II) is a 7.5 kDa peptide which is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly carried in blood in the high molecular weight ternary complex with IGFBP-3 and ALS, and a smaller proportion of IGF-II circulates in association with other IGFBPs [4,5]. Serum IGF-II concentrations increase with postnatal age showing a moderate age-related increase throughout childhood and puberty, and there is no significant variability during the day [6,7]. Serum levels of IGF-II are also dependent on GH secretion. IGF-II levels are low in GH deficiency [7], although IGF-II levels may also decrease in GH excess and with exogenous administration of IGF-I [3]. The combined molar concentrations of IGF-I and IGF-II (i.e. Total serum IGF) is proportional to serum IGFBP-3 and consequently may be useful for evaluation of GH-related disorders [8].

  1. Morgan DO, et al. Nature 329:301-307, 1987.
  2. Conover CA, et al. Biochem Biophys Res Commun 139:501-508, 1986.
  3. Gluckman PD & Ambler GR. Mol Cell Endocrinol 92:C1-C3, 1993
  4. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  5. Rechler M. Vit Horm 47:1-114, 1993.
  6. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  7. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  8. Baxter R & Martin J. J Clin Invest 78: 1504-1512, 1986.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGF-II, Non-Extraction ELISA Test
2. IGF-II, Non-Extraction IRMA Test
3. IGF-II, w/ Extraction IRMA Test
4. Lead Extraction System 5
5. Viscous Fluid Injection / Extraction System - 1360/1361
6. IGF-I ELISA Test (Non-Extraction)
7. IGF-I IRMA Test (Non-Extraction)
8. IGF-I ELISA Test (With Extraction)
9. IGF-I IRMA Test (With Extraction)
10. ViralXpress™ DNA/RNA Extraction Reagent
11. Microplate ELISA Washers - Manual Microplate Washer
2 mm wide x 3 mm long, tapered handle. Angled 45 degrees. Round handle....
3 mm diameter roller blade, 15 mm from angle to tip. Round handle....
5 mm diameter blade. Angled 45 degrees. Hexagonal handle....
3 mm curved blade. Round handle....
Medicine Products:
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network ... advocate for action towards gender equality at their inaugural Summit in New York City ... and reached a social audience of over 3 million. To watch the Mobilize Women ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
Breaking Medicine Technology: