Navigation Links
IGF-II, w/ Extraction ELISA Test

ProductsIGF-II, w/ Extraction ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGF-II, w/ Extraction ELISA Test
Features Inquire
Description Insulin-like growth factor II (IGF-II) is a 7.5 kDa peptide which is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly carried in blood in the high molecular weight ternary complex with IGFBP-3 and ALS, and a smaller proportion of IGF-II circulates in association with other IGFBPs [4,5]. Serum IGF-II concentrations increase with postnatal age showing a moderate age-related increase throughout childhood and puberty, and there is no significant variability during the day [6,7]. Serum levels of IGF-II are also dependent on GH secretion. IGF-II levels are low in GH deficiency [7], although IGF-II levels may also decrease in GH excess and with exogenous administration of IGF-I [3]. The combined molar concentrations of IGF-I and IGF-II (i.e. Total serum IGF) is proportional to serum IGFBP-3 and consequently may be useful for evaluation of GH-related disorders [8].

  1. Morgan DO, et al. Nature 329:301-307, 1987.
  2. Conover CA, et al. Biochem Biophys Res Commun 139:501-508, 1986.
  3. Gluckman PD & Ambler GR. Mol Cell Endocrinol 92:C1-C3, 1993
  4. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  5. Rechler M. Vit Horm 47:1-114, 1993.
  6. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  7. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  8. Baxter R & Martin J. J Clin Invest 78: 1504-1512, 1986.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGF-II, Non-Extraction ELISA Test
2. IGF-II, Non-Extraction IRMA Test
3. IGF-II, w/ Extraction IRMA Test
4. Lead Extraction System 5
5. Viscous Fluid Injection / Extraction System - 1360/1361
6. IGF-I ELISA Test (Non-Extraction)
7. IGF-I IRMA Test (Non-Extraction)
8. IGF-I ELISA Test (With Extraction)
9. IGF-I IRMA Test (With Extraction)
10. ViralXpress™ DNA/RNA Extraction Reagent
11. Microplate ELISA Washers - Manual Microplate Washer
... Katena Products, Inc. is the ... dedicated exclusively to ophthalmic surgical ... to over 7,000 customers in ... a global network of distributors, ...
... Studies have proven that the management of diabetes ... glucose levels is the most effective way to ... care aimed at maintaining or improving a diabetes ... and costly. , ,These have been the ...
... The GlucoWatch G2 Biographer is intended ... glucose levels in adults (aged 18 and ... with diabetes. Parents should supervise the use ... The G2 Biographer is intended to supplement, ...
... The Ex-PRESS is ... provides a simplified,method of filtration ... angle glaucoma.,Similar to trabeculectomy, the ... diverting the aqueous humor from ...
Medicine Products:
(Date:6/24/2017)... ... June 24, 2017 , ... Genes Advice, a ... in select Florida and Texas doctors' offices and clinics. This breakthrough testing is ... genetic testing recognizes the role genes play in determining an individual's tolerance of ...
(Date:6/24/2017)... ... , ... Doorknobs are for convenience, deadbolts are for security. , There are ... having an alarm system installed. But unless there is a working deadbolt lock that ... TX Premier Locksmith in Killeen, TX says: “In the majority of home burglaries, intruders ...
(Date:6/23/2017)... MA (PRWEB) , ... June 23, 2017 , ... ... Care Reconciliation Act (BCRA), their proposed healthcare bill to repeal and replace the ... May, the Senate bill would make significant cuts to Medicaid, a public health ...
(Date:6/23/2017)... ... June 23, 2017 , ... Military Connection friend and veteran advocate ... JFK Virgin Atlantic lounge. , Bensko is no stranger to the plight of ... dedicated her life to supporting our wounded veterans. A world-class photographer, her riveting photos ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring meat ... new videos highlight the importance of correctly using a meat thermometer. The videos ... done extensive research on consumer food safety habits. Dr. Bruhn explains the variety ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... 19, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... on Friday, July 28, 2017, beginning at 7:30 a.m. (CDT) ... Dial-in information: To participate in the conference call, dial (877) ... call at least 10 minutes prior to the start to ... Webcast: A simultaneous webcast ...
(Date:6/14/2017)... 14, 2017  ivWatch LLC, a medical device company ... (IV) therapy, is pleased to announce it was the ... Hospital Supplies and Equipment at the 2017 Medical Design ... medtech industry. The award was presented by Medical Device ... Center in New York during ...
(Date:6/12/2017)... June 12, 2017 Kineta, Inc., a biotechnology company ... Kineta Vice President of R&D and Head of Virology ... Pandemic Preparedness for the Northwest and Beyond meeting sponsored ... June 14, 2017 from 8:30-10:30 AM PDT at the Agora ... Dr. Bedard will be joined by other leaders ...
Breaking Medicine Technology: