Navigation Links
IGF-II, Non-Extraction ELISA Test

ProductsIGF-II, Non-Extraction ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item IGF-II, Non-Extraction ELISA Test
Features Inquire
Description Insulin-like growth factor II (IGF-II) is a 7.5 kDa peptide which is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the receptor for mannose-6-phosphate [1]. However, it is believed that binding to the Type I IGF and insulin receptors may mediate the mitogenic actions of IGF-II [2,3]. In the circulation, the interaction of IGF-II with these receptors appears to be regulated by IGF-binding proteins (IGFBPs). IGF-II is mainly carried in blood in the high molecular weight ternary complex with IGFBP-3 and ALS, and a smaller proportion of IGF-II circulates in association with other IGFBPs [4,5]. Serum IGF-II concentrations increase with postnatal age showing a moderate age-related increase throughout childhood and puberty, and there is no significant variability during the day [6,7]. Serum levels of IGF-II are also dependent on GH secretion. IGF-II levels are low in GH deficiency [7], although IGF-II levels may also decrease in GH excess and with exogenous administration of IGF-I [3]. The combined molar concentrations of IGF-I and IGF-II (i.e. Total serum IGF) is proportional to serum IGFBP-3 and consequently may be useful for evaluation of GH-related disorders [8].

  1. Morgan DO, et al. Nature 329:301-307, 1987.
  2. Conover CA, et al. Biochem Biophys Res Commun 139:501-508, 1986.
  3. Gluckman PD & Ambler GR. Mol Cell Endocrinol 92:C1-C3, 1993
  4. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  5. Rechler M. Vit Horm 47:1-114, 1993.
  6. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  7. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  8. Baxter R & Martin J. J Clin Invest 78: 1504-1512, 1986.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. IGF-II, Non-Extraction IRMA Test
2. IGF-II, w/ Extraction ELISA Test
3. IGF-II, w/ Extraction IRMA Test
4. IGF-I ELISA Test (Non-Extraction)
5. IGF-I IRMA Test (Non-Extraction)
6. Microplate ELISA Washers - Manual Microplate Washer
7. Microplate ELISA Washers - Automated Microplate Washer
8. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
9. RELISA ANA Screening System
10. BioCheck hCG ELISA
11. Human Chorionic Gonadotropin (HCG) ELISA Kit
Increased stent scaffolding at the proximal end gives optimal lumen support and 6F guide catheter compatibility and improved tracking offer excellent deliverability. Customized balloon lengths for ea...
For support, strength and control in your interventions, the RunWay Guide Catheter's large lumen and high-performance design represents a new era in guide catheters....
... Guidants 20-year history, the VOYAGER RX Dilatation ... treatment outcomes. It combines a new low ... profile shaft,more flexible markers, and short taper ... and tortuous anatomy with even greater confidence, ...
The assay is an immunometric ('sandwich') EIA for the quantitative measurement of AFP in human serum or plasma....
Medicine Products:
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: