Navigation Links
IGF-I IRMA Test (Non-Extraction)

ProductsIGF-I IRMA Test (Non-Extraction)
Company Diagnostic Systems Laboratories, Inc.
Item IGF-I IRMA Test (Non-Extraction)
Description Insulin-like growth factor I (IGF-I or somatomedin C) is a 7.6 kDa peptide produced primarily in the liver. It acts as a potent mitogen of cellular proliferation, exerting its actions by binding to specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3].

IGF-I concentrations in serum are dependent on age and sex. Levels increase from birth through mid-puberty, then decline to relatively stable levels during adult life, with a modest decrease in elderly people. In addition, IGF-I levels remain relatively stable throughout the day [4,5]. IGF-I is also dependent on growth hormone (GH) secretion, with IGF-I mediating many of the actions of GH [6]. In GH deficiency, malnutrition [4] and GH-receptor deficiency [7], serum IGF-I levels are low. Conversely, in acromegaly (GH excess) serum IGF-I levels are elevated [4,6]. Measurement of IGF-I levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders. Additionally, there is a growing research interest in the role of IGF-I in cancer risk assessment [8.9].

  1. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  2. Rechler M. Vit Horm 47:1-114, 1993.
  3. Juul A. et al. J Clin Endocrinol Metab 82: 2497-2502, 1997.
  4. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  5. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  6. Daughaday E & Rotwein P. Endocrin Rev 10:68-91, 1989.
  7. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76:417-423, 1993.
  8. Chan JM, et al. Science 279:563-566, 1998.
  9. Hankinson SE, et al. The Lancet 351:1373-1374, 1998.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site:

Related medicine products :

1. Insulin-like Growth Factor-I (IGF-I) ELISA
5. IGF-I
6. Free IGF-I ELISA Test
7. IGF-I ELISA Test (Non-Extraction)
8. IGF-I ELISA Test (With Extraction)
9. IGF-I IRMA Test (With Extraction)
10. Free IGF-I IRMA Test
11. IGF-II, Non-Extraction ELISA Test
It provides excellent illumination from an inexpensive platform and is mounted on the comfortable UltraLite headband....
... A rapid rise in ... recognition, intervention and continuous ... fiberoptic technology that gets ... pressure. Its versatility makes ...
... The Codman ICP ... accurate measurements of intracranial ... parenchymal or intraventricular levels. ... electronically rather than through ...
Slightly curved blunt dissector, double-ended. Length 11 1/2" (272 mm)...
Medicine Products:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: