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IGF-I ELISA Test (With Extraction)

ProductsIGF-I ELISA Test (With Extraction)
Company Diagnostic Systems Laboratories, Inc.
Item IGF-I ELISA Test (With Extraction)
Features 
Description Insulin-like growth factor I (IGF-I or somatomedin C) is a 7.6 kDa peptide produced primarily in the liver. It acts as a potent mitogen of cellular proliferation, exerting its actions by binding to specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3].

IGF-I concentrations in serum are dependent on age and sex. Levels increase from birth through mid-puberty, then decline to relatively stable levels during adult life, with a modest decrease in elderly people. In addition, IGF-I levels remain relatively stable throughout the day [4,5]. IGF-I is also dependent on growth hormone (GH) secretion, with IGF-I mediating many of the actions of GH [6]. In GH deficiency, malnutrition [4] and GH-receptor deficiency [7], serum IGF-I levels are low. Conversely, in acromegaly (GH excess) serum IGF-I levels are elevated [4,6]. Measurement of IGF-I levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders. Additionally, there is a growing research interest in the role of IGF-I in cancer risk assessment [8.9].

  1. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  2. Rechler M. Vit Horm 47:1-114, 1993.
  3. Juul A. et al. J Clin Endocrinol Metab 82: 2497-2502, 1997.
  4. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  5. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  6. Daughaday E & Rotwein P. Endocrin Rev 10:68-91, 1989.
  7. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76:417-423, 1993.
  8. Chan JM, et al. Science 279:563-566, 1998.
  9. Hankinson SE, et al. The Lancet 351:1373-1374, 1998.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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Adjustable wire speculum with 17 mm open blades. Lid tension adjustable throughout procedure with thumb screw control. Shaft angled 45 degrees. Manufactured in titanium....
Open 14 mm blades with 10 mm lifting wings. Lightweight wire. Dull finish....
Angled for temporal approach. Solid 14 mm blades. Dull finish....
Open 14 mm blades with 6 mm lifting wings. Dull finish....
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