Navigation Links
IGF-I ELISA Test (Non-Extraction)

ProductsIGF-I ELISA Test (Non-Extraction)
Company Diagnostic Systems Laboratories, Inc.
Item IGF-I ELISA Test (Non-Extraction)
Features 
Description Insulin-like growth factor I (IGF-I or somatomedin C) is a 7.6 kDa peptide produced primarily in the liver. It acts as a potent mitogen of cellular proliferation, exerting its actions by binding to specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3].

IGF-I concentrations in serum are dependent on age and sex. Levels increase from birth through mid-puberty, then decline to relatively stable levels during adult life, with a modest decrease in elderly people. In addition, IGF-I levels remain relatively stable throughout the day [4,5]. IGF-I is also dependent on growth hormone (GH) secretion, with IGF-I mediating many of the actions of GH [6]. In GH deficiency, malnutrition [4] and GH-receptor deficiency [7], serum IGF-I levels are low. Conversely, in acromegaly (GH excess) serum IGF-I levels are elevated [4,6]. Measurement of IGF-I levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders. Additionally, there is a growing research interest in the role of IGF-I in cancer risk assessment [8.9].

  1. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  2. Rechler M. Vit Horm 47:1-114, 1993.
  3. Juul A. et al. J Clin Endocrinol Metab 82: 2497-2502, 1997.
  4. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  5. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  6. Daughaday E & Rotwein P. Endocrin Rev 10:68-91, 1989.
  7. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76:417-423, 1993.
  8. Chan JM, et al. Science 279:563-566, 1998.
  9. Hankinson SE, et al. The Lancet 351:1373-1374, 1998.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Insulin-like Growth Factor-I (IGF-I) ELISA
2. IMMULITE/IMMULITE 1000 IGF-I
3. IMMULITE 2500 IGF-I
4. IMMULITE 2000 IGF-I
5. IGF-I
6. Free IGF-I ELISA Test
7. IGF-I IRMA Test (Non-Extraction)
8. IGF-I ELISA Test (With Extraction)
9. IGF-I IRMA Test (With Extraction)
10. Free IGF-I IRMA Test
11. IGF-II, Non-Extraction ELISA Test
The SURGIWIP™ suture ligature with delivery system is indicated for use in gynecologic, general and other abdominal and thoracic endoscopic procedures where a suture is appropriate for the endo...
Surgitie&trade Single Use Ligating Loops with Delivery System...
ENDO STITCH&trade Triple-Stitch Single Use Loading Units for use with ENDO Stitch* 10 mm Suturing Device....
ENDO STITCH™ Single Use Loading Units....
Medicine Products:
(Date:2/13/2016)... ... February 13, 2016 , ... DDi ... Management Solution Providers list for its expertise in eClinical Solutions. DDi has built ... serve the technology needs of global clients. DDi provides smarter technology for Clinical ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... community at its 10th anniversary Fashion Luncheon on Monday, February 8, 2016. The ...
(Date:2/12/2016)... ... ... Coco Libre, the maker of coconut water beverages with a purpose, is ... Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut Water, a ... suite, held this year at the W Hollywood Hotel, has become a pre-show “must” ...
(Date:2/12/2016)... NV (PRWEB) , ... February 12, 2016 , ... Fisher ... Las Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and ... House at the VA Southern Nevada Healthcare System. This will be the first ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a ... beginning of the latest charity campaign in their community enrichment program. Art Expression ... this worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... LONDON , Feb. 11, 2016 Stem ... that are characterized by self-renewal and the capacity to ... a relatively new discovery, as the first mouse embryonic ... it was not until 1995 that the first culturing ... pluripotent stem cells were not produced until 2006 As ...
(Date:2/11/2016)... 11, 2016  Walgreens has committed to provide drug ... Washington, D.C. as part of a ... commended by shareholder advocacy organization As You Sow. ... "Many people hold on to unneeded drugs because they lack ... consequences." --> Conrad MacKerron , Senior Vice ...
(Date:2/11/2016)...  NOIT™ Research LLC, a private, leading-edge autism research ... to assist needy families in obtaining one of its ... February 10, 2016 and March 31, 2016, the company ... NOIT is an auditory stimulus that plays a key ... Beth Shier , NOIT Research director. ...
Breaking Medicine Technology: