Navigation Links
GBM -Ab EIA Auto-Immune Markers 013-GBM-48 Glomerular Basement Membrane

ProductsGBM -Ab EIA Auto-Immune Markers 013-GBM-48 Glomerular Basement Membrane
Company ALPCO Diagnostics
Item GBM -Ab EIA Auto-Immune Markers 013-GBM-48 Glomerular Basement Membrane
Features 
Description This Immunoscan Anti-GBM was developed to detect the presence of antibodies against the glomerular basement membrane. The information is clinically useful in diagnosing Goodpastures syndrome, where anti-collagen (IV) - a3 chain antibody formation along with glomerulonephritis and pulmonary hemorrhage are primary diagnostic parameters. Since there are several other conditions presenting with similar symptoms, developed independently from anti-glomerular basement membrane (GBM) antibodies, this test can help to differentiate between these autoimmune renal disorders. The antigen used in the test is the M2 subunit purified from the noncollagenous (NC1) domain of type IV collagen. This antigen is fully described in the review article Biology of Disease Goodpasture Syndrome: Molecular Architecture and Function of Basement Membrane Antigen (1). Recent studies have shown that all Goodpasture patients have antibodies directed against M2 and some patients have additional antibodies against other basement membrane constituents and/or other collagen IV domains. The use of this purified antigen does not give false positive results for patient specimens containing other autoantibodies to the GBM, in contrast to crude collagenase digests of the total GBM (2). Glomerulonephritis is a major cause of irreversible renal failure. Many forms of glomerulonephritis are caused by immunological mechanisms, whereby a person forms antibodies against his own tissue components (auto-immunity) (3). Dixon and coworkers (4, 5) showed that in one particular type of glomerulonephritis, originally described by Ernest Goodpasture in 1919 (6) and subsequently referred to as Goodpastures syndrome (7), the disease was caused by an antibody response against antigens present in the glomerular basement membrane (GBM). Thus the disease is sometimes referred to as anti-GBM mediated glomerulonephritis. While Goodpastures syndrome is a relatively rare condition, the disease is rapidly progressive and, unless treated, has a case-fatality rate of 75-90% (8). Immediate and correct treatment is necessary before kidney (and often lung) damage has progressed too far. In clinical practice the diagnosis and recognition of the disease is frequently delayed since it is unexpected. Clinical signs such as hemoptysis, precipitate anemia, pulmonary opacities at x-ray and/or oliguria are in a sense unspecific and common to a variety of disorders. Mild prodromal lung or kidney symptoms are often overlooked or masked by a precipitating infection. The Immunoscan Anti-GBM offered is based on ELISA methodology (15, 16). The test utilizes wells coated with purified GBM antigen. Diluted patient serum is applied to the well and incubated. If specific anti-GBM antibodies are present they will bind to the antigen. Unbound material is washed away and any bound antibody is detected by adding enzyme-labeled anti-human IgG, followed by a second washing step and incubation with substrate. A well containing anti-GBM antibody will develop a color, which can be quantified.
Info ALPCO DiagnosticsCall ALPCO Diagnostics to buy products (US and Canada only; other locations use number below) USACanada1-866-466-7731

Customer Service: (800) 592-5726
Web site: http://www.alpco.com

Related medicine products :

1. CIC (C1-q) EIA Auto-Immune Markers 001-EK-CIC Circulating Immune Complexes
2. GBM -Ab EIA Auto-Immune Markers 013-GBM-96 Glomerular Basement Membrane
3. Anti-PR3 EIA Auto-Immune Markers 013-PR3-48 Proteinase
4. Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-96 Myeloperoxidase
5. Anti-PR3 EIA Auto-Immune Markers 013-PR3-96 Proteinase
6. Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-48 Myeloperoxidase
7. ENA Screen EIA Auto-Immune Markers 012-MDKES1 Extractable Nuclear Antigens
8. Surgical Markers
9. TLS Surgical Markers
10. SQUEEZE-MARK Surgical Markers
11. Iso-Insulin EIA Diabetes and Obesity Markers 008-10-1128-01
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products:
(Date:12/6/2016)... ... December 06, 2016 , ... Specialty ... newly updated International Audit Protocol Consortium (IAPC) EHS audit protocol for Great ... understand the scope of their EHS regulatory obligations and rapidly collect, share, archive, ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... magazine’s 2017 Training Top 125 for their industry leading training methods that engage ... recognizes USA as among the global elite in employer-sponsored training and development programs. ...
(Date:12/5/2016)... ... 2016 , ... The Avamere Family of Companies will celebrate ... Care of Puget Sound ; located at 630 S Pearl Street, Tacoma, WA ... recovering from illness or injury with intensive skilled nursing and rehabilitation services. Much ...
(Date:12/5/2016)... Petersburg, Fla. (PRWEB) , ... December 05, 2016 , ... ... concussions have on the growing brains of young athletes. Over the course of three ... the head through unique mouth guards. The mouth guards, equipped with special sensors, will ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... the 21st Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and ... Talamo said, “We are honored to have Amy E. Herman present at this ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Calif. , Dec. 5, 2016 Sanovas, ... technology accelerator, announced today the launch of its wholly owned ... Logo - http://photos.prnewswire.com/prnh/20161202/445250LOGO   Logo - http://photos.prnewswire.com/prnh/20161202/445251LOGO ... ... There ...
(Date:12/5/2016)... 5, 2016  New research by the CVS ... and the U.S. Department of Health and Human ... and Response (ASPR), published online today in ... notifications encourage patients with chronic conditions to refill ... study also affirms that public-private partnerships can facilitate ...
(Date:12/5/2016)... , Dec. 5, 2016 Eisai Inc. ... at the 2016 Annual Meeting of the American Epilepsy ... CIII, is indicated as an adjunctive therapy for the ... secondarily generalized seizures and primary generalized tonic-clonic seizures (PGTC) ... age and older. Please see Important Safety Information for ...
Breaking Medicine Technology: