Navigation Links
Free IGF-I IRMA Test

ProductsFree IGF-I IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Free IGF-I IRMA Test
Features 
Description Insulin-like growth factor I (IGF-I or somatomedin C) is a 7.6 kDa peptide produced primarily in the liver. It acts as a potent mitogen of cellular proliferation, exerting its actions by binding to specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3].

IGF-I concentrations in serum are dependent on age and sex. Levels increase from birth through mid-puberty, then decline to relatively stable levels during adult life, with a modest decrease in elderly people. In addition, IGF-I levels remain relatively stable throughout the day [4,5]. IGF-I is also dependent on growth hormone (GH) secretion, with IGF-I mediating many of the actions of GH [6]. In GH deficiency, malnutrition [4] and GH-receptor deficiency [7], serum IGF-I levels are low. Conversely, in acromegaly (GH excess) serum IGF-I levels are elevated [4,6]. Measurement of IGF-I levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders. Additionally, there is a growing research interest in the role of IGF-I in cancer risk assessment [8.9].

  1. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  2. Rechler M. Vit Horm 47:1-114, 1993.
  3. Juul A. et al. J Clin Endocrinol Metab 82: 2497-2502, 1997.
  4. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  5. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  6. Daughaday E & Rotwein P. Endocrin Rev 10:68-91, 1989.
  7. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76:417-423, 1993.
  8. Chan JM, et al. Science 279:563-566, 1998.
  9. Hankinson SE, et al. The Lancet 351:1373-1374, 1998.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Insulin-like Growth Factor-I (IGF-I) ELISA
2. IMMULITE/IMMULITE 1000 IGF-I
3. IMMULITE 2500 IGF-I
4. IMMULITE 2000 IGF-I
5. IGF-I
6. Free IGF-I ELISA Test
7. IGF-I ELISA Test (Non-Extraction)
8. IGF-I IRMA Test (Non-Extraction)
9. IGF-I ELISA Test (With Extraction)
10. IGF-I IRMA Test (With Extraction)
11. IGF-II, Non-Extraction ELISA Test
Expressions lets you change your eye color with lenses that offer incredible comfort and outstanding vision quality. Expression color lenses use a technologically advanced tinting process to produce ...
... The world standard in corneal ... like endothelium, descemet's membrane, stroma, Bowman's ... of Corneal Components. Broad Applications in ... pachymetry, post-surgery interface evaluation, endothelial cell ...
... the appearance of photo-aged skin, removes age ... telangiectasias, and broken capillaries. This innovative new ... pigmentary sun damage through a process called ... and the Nd:YAG Laser is optimized for ...
... The new IPL Quantum DL system ... with the reliability and simplicity expected ... modular and upgradeable design protects your ... SR mode for IPL skin treatments ...
Medicine Products:
(Date:12/9/2016)... ... December 09, 2016 , ... ... offices in Pasco and Richland, is initiating a charity drive to support the ... from a recent automobile collision. , On October 29th of this year, ...
(Date:12/9/2016)... ... 2016 , ... The Justin Veatch Fund announced Thursday that ... film Whispering Spirits and its discussion guide for use by all of ... in the war against teen drug abuse. NCADD is the oldest anti-addiction advocacy ...
(Date:12/9/2016)... ... December 09, 2016 , ... The ... Hotel in New York, NY, on December 3rd, to benefit Holy Name Medical ... the annual event, which raised over $1 million - the largest event in ...
(Date:12/8/2016)... ... 2016 , ... The West Virginia Medical Institute (WVMI) announced ... name change aligns the entire company with its existing Quality Insights branded projects ... are very proud of the achievements associated with the West Virginia Medical Institute ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate that ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... -- Australia Ophthalmic Lasers Market Outlook to 2022 ... Outlook to 2022", provides key market data on the ... millions of US dollars, volume (in units) and average ... Lasers and YAG Lasers. The report also provides ... these market segements, and global corporate-level profiles of the ...
(Date:12/8/2016)...  The global biosurgery market is expected to grow ... of 2016 to 2021. The market is poised to ... billion in 2016. The market is primarily driven by ... injuries and spinal problems, increasing clearance of biosurgery products ... loss management. In this report, the biosurgery ...
(Date:12/8/2016)... KEY FINDINGS North America ... market in 2016 and is expected to continue in ... a large number of surgical procedures that are taking ... in the patient temperature management market.) Patient warming and ... of blood during surgeries, lowering the risks of neurological ...
Breaking Medicine Technology: