Navigation Links
Free IGF-I IRMA Test

ProductsFree IGF-I IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Free IGF-I IRMA Test
Features 
Description Insulin-like growth factor I (IGF-I or somatomedin C) is a 7.6 kDa peptide produced primarily in the liver. It acts as a potent mitogen of cellular proliferation, exerting its actions by binding to specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3].

IGF-I concentrations in serum are dependent on age and sex. Levels increase from birth through mid-puberty, then decline to relatively stable levels during adult life, with a modest decrease in elderly people. In addition, IGF-I levels remain relatively stable throughout the day [4,5]. IGF-I is also dependent on growth hormone (GH) secretion, with IGF-I mediating many of the actions of GH [6]. In GH deficiency, malnutrition [4] and GH-receptor deficiency [7], serum IGF-I levels are low. Conversely, in acromegaly (GH excess) serum IGF-I levels are elevated [4,6]. Measurement of IGF-I levels in serum is a useful diagnostic test for the clinical evaluation of GH-related disorders. Additionally, there is a growing research interest in the role of IGF-I in cancer risk assessment [8.9].

  1. Baxter RC, et al. J Biol Chem 264:11843-11848, 1989.
  2. Rechler M. Vit Horm 47:1-114, 1993.
  3. Juul A. et al. J Clin Endocrinol Metab 82: 2497-2502, 1997.
  4. Lee PDK & Rosenfeld RG. Pediatrician 14:154-161, 1987.
  5. Rosenfeld RG, et al. J. Pediatr 109:428-433, 1986.
  6. Daughaday E & Rotwein P. Endocrin Rev 10:68-91, 1989.
  7. Guevara-Aguirre J, et al. J Clin Endocrinol Metab 76:417-423, 1993.
  8. Chan JM, et al. Science 279:563-566, 1998.
  9. Hankinson SE, et al. The Lancet 351:1373-1374, 1998.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Insulin-like Growth Factor-I (IGF-I) ELISA
2. IMMULITE/IMMULITE 1000 IGF-I
3. IMMULITE 2500 IGF-I
4. IMMULITE 2000 IGF-I
5. IGF-I
6. Free IGF-I ELISA Test
7. IGF-I ELISA Test (Non-Extraction)
8. IGF-I IRMA Test (Non-Extraction)
9. IGF-I ELISA Test (With Extraction)
10. IGF-I IRMA Test (With Extraction)
11. IGF-II, Non-Extraction ELISA Test
Dual-sided, Interhemispheric Grid Electrode with 16 Contact Leads; Cortical Grid Electrode with 16 Contact Leads; Pediatric Grid Electrode with Flex Connector, 0.5 cm spacing...
... Integra Epilepsy cortical strip electrodes are ... intracranial placement through a burr hole. ... tunneling and enables quick and secure ... Like all Integra Epilepsy electrode designs, ...
... Epilepsy Flex Connector represents a ... of epilepsy electrodes. This versatile ... and attachment to the electrode ... is provided with a peel-away ...
...
Medicine Products:
(Date:8/16/2017)... , ... August 16, 2017 , ... Fusion Flix Inc., ... original programming over four countries and millions of viewers in a partnership with the ... or buy On-Demand and fully available on Blu Ray disc in 2018. Proceeds will ...
(Date:8/16/2017)... Utah (PRWEB) , ... August 16, 2017 , ... Connexion ... the Inc 5000 list for the fourth consecutive year. With 197% revenue ... 2017 list of the nation’s fastest growing companies. , Previous honors include ...
(Date:8/16/2017)... Ridge, NJ (PRWEB) , ... August 16, 2017 ... ... Hills is offering an opportunity for men and women to train as ... their families dealing with life-limiting illness. For over 30 years, the agency has ...
(Date:8/16/2017)... ... 16, 2017 , ... As part of the Arrow Wellness ... their local business community, Riverfront Fitness is the first of many recipients vying ... integral part of treating those suffering from sudden cardiac arrest in the few ...
(Date:8/16/2017)... ... , ... With low back pain afflicting 8 of 10 Americans at some point in their ... back pain. But this equally vexing condition stems from a variety of causes that can ... PhD , founder and president of Atlantic Spine Center. , Nestled between your neck ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... HOUSTON , Aug. 15, 2017   Mostyn Law ... in Houston, Texas . The Mostyn Law ... the past 2 years. That is why Mostyn Law ... Texas to show its appreciation. Blood supplies ... to fall 5% short of hospital needs in August. That is ...
(Date:8/15/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO), is now ... residents. Naloxone is available without a ... pharmacy, G-3320 Beecher Road. ... Administration, is intended to block or reverse the effects ... of consciousness. The medication is often carried by first ...
(Date:8/15/2017)... HIGH POINT, N.C. , Aug. 15, 2017  Axium Pharmaceuticals Inc., ... epilepsy is rumored to be in the beginning stages of an IPO. ... billion annually on epilepsy medications with the average cost of a prescription ... ... Another staggering figure is ...
Breaking Medicine Technology: