Navigation Links
Free Activin B ELISA Test

ProductsFree Activin B ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Free Activin B ELISA Test
Features Inquire
Description Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors which control many aspects of development, reproductive function and tumor formation (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins.

Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in the ovary and testis, but can be found in a variety of other tissues (2). In addition to their endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary cells, gonadal and neuronal cell lines, and hematopoietic progenitor and erythroleukemia cells (2).

Two binding proteins have been described for the Activins and Inhibins: Follistatin and a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3).

Despite numerous studies investigating the circulating levels of the various activin molecules in numerous disease states, no clear physiological roles have been established other than the stimulatory action on pituitary FSH secretion. However, a number of recent studies have indicated that the measurement of Activin may be useful as a predictor of pre-eclampsia (4,5), preterm labor (6) and various oncological conditions (7).

  1. Chang H et al. Endocrine Rev 23: 787-823, 2002.
  2. Meunier H et al. Proc Natl Acad Sci USA 85: 247-251, 1988.
  3. Krummen LA et al. Endocrinology 132: 431-443, 1993.
  4. Muttukrishna S et al. Lancet 349:1285-1288, 1997.
  5. Muttukrishna S et al. Hum Reprod 15(7):1640-1645, 2000.
  6. Lockwood GM et al. Biol Reprod 57(6):1490-1494, 1997.
  7. Lambert-Messerlian GM et al. Gynecol Oncol 74(1):93-97, 1999.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Free Activin A ELISA Test
2. Free Activin AB ELISA Test
3. Microplate ELISA Washers - Manual Microplate Washer
4. Microplate ELISA Washers - Automated Microplate Washer
5. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
6. RELISA ANA Screening System
7. BioCheck hCG ELISA
8. Human Chorionic Gonadotropin (HCG) ELISA Kit
9. Human PSA ELISA Kit
10. Total PSA ELISA Test
11. Free PSA ELISA
For use with cushioned neckband....
Bivona® Uncuffed Neonatal and Pediatric Silicone Tracheostomy Tubes....
Fome-Cuf® tubes can breathe with the patient to provide a safe, effective, and low pressure seal throughout the ventilatory cycle....
... Adjustable neck flange tracheostomy ... use until the proper length ... be obtained. , ,Adjustable ... can be adjusted for both ...
Medicine Products:
(Date:1/17/2017)... ... January 17, 2017 , ... ... as Palm Desert, is opening a new office in San Clemente, California this ... stimulation (dTMS) in Southern California, successfully treating individuals struggling with major depression. Depression ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples Health is pleased ... network on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves ... exciting addition to our provider network, and the addition will benefit our members ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... today announced its partnership with Sigfox in the U.S.A. to offer ... nationwide including new offerings on large-scale environmental sensor deployments such as monitoring ...
(Date:1/17/2017)... ... 17, 2017 , ... SC&H Group, a leading audit, tax, and consulting firm, ... IT Advisory Services practice . Rossi is the third technology consulting leader to join ... guidance grows, and the practice continues to expand.     , Bringing more than 25 years ...
(Date:1/17/2017)... ... 17, 2017 , ... Physicians Education Review®, LCC (PER®) announces ... for the 34th Annual Miami Breast Cancer Conference®, on March 9-12, 2017 at ... Talamo, said, “We are delighted to have Sandra Lee join us as our ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 2017 Following an initial analysis, the ... Food and Drug Administration,s (FDA,s) final regulatory guidance ... by Pharmacies and Outsourcing Facilities." In its final ... pre-packaging -- which would have put patients at ... term care (LTC) pharmacies.  The ...
(Date:1/17/2017)... Research and Markets has announced the addition ... Manufacturer (Captive, Merchant), Synthesis (Synthetic, Biotech), Product (mAb, Hormone) Drug (OTC, ... report to their offering. ... The global active pharmaceutical ingredients market is expected ... in 2016, growing at a CAGR of 6.3% from 2016 to ...
(Date:1/17/2017)... , Jan. 17, 2017  In a preview of ... Annual Congress, Astute Medical, Inc., developer of the NephroCheck ... the test, which identifies hospital patients at risk of developing ... take place this month at the Hawaii ... January 21 through January 25. AKI is one ...
Breaking Medicine Technology: