Navigation Links
Free Activin B ELISA Test

ProductsFree Activin B ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Free Activin B ELISA Test
Features Inquire
Description Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors which control many aspects of development, reproductive function and tumor formation (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins.

Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in the ovary and testis, but can be found in a variety of other tissues (2). In addition to their endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary cells, gonadal and neuronal cell lines, and hematopoietic progenitor and erythroleukemia cells (2).

Two binding proteins have been described for the Activins and Inhibins: Follistatin and a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3).

Despite numerous studies investigating the circulating levels of the various activin molecules in numerous disease states, no clear physiological roles have been established other than the stimulatory action on pituitary FSH secretion. However, a number of recent studies have indicated that the measurement of Activin may be useful as a predictor of pre-eclampsia (4,5), preterm labor (6) and various oncological conditions (7).

  1. Chang H et al. Endocrine Rev 23: 787-823, 2002.
  2. Meunier H et al. Proc Natl Acad Sci USA 85: 247-251, 1988.
  3. Krummen LA et al. Endocrinology 132: 431-443, 1993.
  4. Muttukrishna S et al. Lancet 349:1285-1288, 1997.
  5. Muttukrishna S et al. Hum Reprod 15(7):1640-1645, 2000.
  6. Lockwood GM et al. Biol Reprod 57(6):1490-1494, 1997.
  7. Lambert-Messerlian GM et al. Gynecol Oncol 74(1):93-97, 1999.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Free Activin A ELISA Test
2. Free Activin AB ELISA Test
3. Microplate ELISA Washers - Manual Microplate Washer
4. Microplate ELISA Washers - Automated Microplate Washer
5. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
6. RELISA ANA Screening System
7. BioCheck hCG ELISA
8. Human Chorionic Gonadotropin (HCG) ELISA Kit
9. Human PSA ELISA Kit
10. Total PSA ELISA Test
11. Free PSA ELISA
... 5mm AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
... The AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
... The AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
Medicine Products:
(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
Breaking Medicine Technology: