Navigation Links
Free Activin AB ELISA Test

ProductsFree Activin AB ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Free Activin AB ELISA Test
Features Inquire
Description Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors which control many aspects of development, reproductive function and tumor formation (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins.

Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in the ovary and testis, but can be found in a variety of other tissues (2). In addition to their endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary cells, gonadal and neuronal cell lines, and hematopoietic progenitor and erythroleukemia cells (2).

Two binding proteins have been described for the Activins and Inhibins: Follistatin and a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3).

Despite numerous studies investigating the circulating levels of the various activin molecules in numerous disease states, no clear physiological roles have been established other than the stimulatory action on pituitary FSH secretion. However, a number of recent studies have indicated that the measurement of Activin may be useful as a predictor of pre-eclampsia (4,5), preterm labor (6) and various oncological conditions (7).

  1. Chang H et al. Endocrine Rev 23: 787-823, 2002.
  2. Meunier H et al. Proc Natl Acad Sci USA 85: 247-251, 1988.
  3. Krummen LA et al. Endocrinology 132: 431-443, 1993.
  4. Muttukrishna S et al. Lancet 349:1285-1288, 1997.
  5. Muttukrishna S et al. Hum Reprod 15(7):1640-1645, 2000.
  6. Lockwood GM et al. Biol Reprod 57(6):1490-1494, 1997.
  7. Lambert-Messerlian GM et al. Gynecol Oncol 74(1):93-97, 1999.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Free Activin B ELISA Test
2. Free Activin A ELISA Test
3. Microplate ELISA Washers - Manual Microplate Washer
4. Microplate ELISA Washers - Automated Microplate Washer
5. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
6. RELISA ANA Screening System
7. BioCheck hCG ELISA
8. Human Chorionic Gonadotropin (HCG) ELISA Kit
9. Human PSA ELISA Kit
10. Total PSA ELISA Test
11. Free PSA ELISA
... is the lancing device that has set ... since 1983. This re-usable lancing device assists ... The auto-Lancet is constructed in the USA ... after day, year after year. It's the ...
... Elite has become one of the ... popularity is due to the great ... the design and function of the ... is priced for far less than ...
... Finnpipette Techpette combines form and ... pipette. Advanced pipetting technology, plus ... quality, safety, comfort and accuracy. ... range is an important safety ...
... The Finnpipette Digital offers improved ... The rounded handle, modified grippy finger ... enhance operator comfort and efficiency. Finnpipette ... with power-boosted gearing mechanism (pat. pend.) ...
Medicine Products:
(Date:2/12/2016)... Malvern, Pa. (PRWEB) , ... February 12, 2016 ... ... help sort through a world of exterior design possibilities. CertainTeed, North America’s leading ... visualization tools by expanding the product offerings showcased in the mobile version of ...
(Date:2/12/2016)... ... February 12, 2016 , ... Healthcare careers in the medical laboratory, ... jobs via the website of healthcare staffing leader Aureus Medical Group during the month ... , travel therapy positions and in travel and direct hire opportunities in ...
(Date:2/12/2016)... ... 2016 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... says are the real facts surrounding all those Bible stories. For generations families have ... teachers, and Yisrayl says there is more to these than just mere “stories”. ...
(Date:2/12/2016)... ... February 12, 2016 , ... With the exception of restorative dentistry, to date there ... With the recent approval by the FDA, there is a now a new protocol ... varnish, SDF is very simple and quick to apply. The application is as simple ...
(Date:2/11/2016)... ... ... “ HEALING MIND : Five Steps to Ultimate Healing, Four Rooms for ... readers how to become their own therapist. Providing a useful step-by-step process for achieving ... an understanding of how to heal one’s inner child using four archetypes of Christianity. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Walgreens has committed to ... states and Washington, D.C. as part ... that was commended by shareholder advocacy organization As You Sow. ... You Sow. "Many people hold on to unneeded drugs because ... have tragic consequences." --> Conrad MacKerron , ...
(Date:2/11/2016)... 11, 2016   Health 2.0 , the premiere ... technologies, announced today " 10 Year Global Retrospective ", ... over the past ten years.   ... Health 2.0 has served as the preeminent thought-leader in ... thousands of technologies, companies, innovators, and patient-activists through an ...
(Date:2/11/2016)...  NOIT™ Research LLC, a private, leading-edge autism research ... to assist needy families in obtaining one of its ... February 10, 2016 and March 31, 2016, the company ... NOIT is an auditory stimulus that plays a key ... Beth Shier , NOIT Research director. ...
Breaking Medicine Technology: