Navigation Links
Free Activin AB ELISA Test

ProductsFree Activin AB ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item Free Activin AB ELISA Test
Features Inquire
Description Activins are polypeptide hormones which belong to the transforming growth factor- (TGF-) superfamily. The TGF- superfamily is a large group of extra-cellular growth factors which control many aspects of development, reproductive function and tumor formation (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins.

Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are homo- or heterodimers consisting of A or B subunits producing Activin A, B, and AB, and have been shown to stimulate FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in the ovary and testis, but can be found in a variety of other tissues (2). In addition to their endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary cells, gonadal and neuronal cell lines, and hematopoietic progenitor and erythroleukemia cells (2).

Two binding proteins have been described for the Activins and Inhibins: Follistatin and a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3).

Despite numerous studies investigating the circulating levels of the various activin molecules in numerous disease states, no clear physiological roles have been established other than the stimulatory action on pituitary FSH secretion. However, a number of recent studies have indicated that the measurement of Activin may be useful as a predictor of pre-eclampsia (4,5), preterm labor (6) and various oncological conditions (7).

  1. Chang H et al. Endocrine Rev 23: 787-823, 2002.
  2. Meunier H et al. Proc Natl Acad Sci USA 85: 247-251, 1988.
  3. Krummen LA et al. Endocrinology 132: 431-443, 1993.
  4. Muttukrishna S et al. Lancet 349:1285-1288, 1997.
  5. Muttukrishna S et al. Hum Reprod 15(7):1640-1645, 2000.
  6. Lockwood GM et al. Biol Reprod 57(6):1490-1494, 1997.
  7. Lambert-Messerlian GM et al. Gynecol Oncol 74(1):93-97, 1999.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

Related medicine products :

1. Free Activin B ELISA Test
2. Free Activin A ELISA Test
3. Microplate ELISA Washers - Manual Microplate Washer
4. Microplate ELISA Washers - Automated Microplate Washer
5. Vitamin D 25-Hydroxy ELISA 026-AC-57F1 Bone and Mineral Metabolism
6. RELISA ANA Screening System
7. BioCheck hCG ELISA
8. Human Chorionic Gonadotropin (HCG) ELISA Kit
9. Human PSA ELISA Kit
10. Total PSA ELISA Test
11. Free PSA ELISA
... EXCLUDER AAA Endoprosthesis is an innovative device ... option for patients with abdominal aortic aneurysms ... ePTFE bifurcated graft with an outer self-expanding ... flexibility and material durability. The function of ...
... Gore's EXCLUDER AAA Endoprosthesis is an innovative ... treatment option for patients with abdominal aortic ... durable ePTFE bifurcated graft with an outer ... device flexibility and material durability. The function ...
... saw to remove a cast from an arm ... Occasionally patients are cut or burned by the ... healthcare professionals to remove any cast with confidence. ... against cuts and burns from the cast saw ...
... Liner (formerly sold as GORE Cast Liner) ... thus minimizing discomfort and other cast related ... waterproof, breathable, washable cast padding that replaces ... fiberglass cast. It allows patients the freedom ...
Medicine Products:
(Date:5/25/2016)... ... ... The Bank of America Charitable Foundation has awarded a grant to the General ... employment and successful careers in healthcare. On Wednesday, May 4th, Rick Bridwell, Bank of ... Medisend, parent organization and home of the General Myers Veterans Program. , “The ...
(Date:5/25/2016)... ... ... CloudLIMS, joins an elite number of companies that have earned a spot ... by CIOReview. , In a deliberate session with the honorary industrial experts, a list ... concluded with. The positioning is based on evaluation of CloudLIMS’ specialties in Automated Sample ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Global Wellness Summit ... unique integrative medical wellness offerings of Europe, a continent that pioneered the medical/wellness concept ... hear from numerous pioneers in medical wellness, including Henri Chenot, Founder of the Chenot ...
(Date:5/25/2016)... FRANCISCO, CA (PRWEB) , ... May 25, 2016 , ... ... School of Nursing and Health Professions. She will lead a team of more than ... Team. Baker will begin her role as dean in late August. , Baker comes ...
(Date:5/25/2016)... ... May 25, 2016 , ... BeniComp Insurance Company, a ... in their clients' employee participation for their wellness initiatives. BeniComp clients experience ... high-deductible health plan with outcome-based deductible incentives. As a result, BeniComp clients have ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , Deutschland und GERMANTOWN, Maryland ... Zusammenarbeit mit Therawis bedient dringenden ... Brustkrebs   QIAGEN N.V. (NASDAQ: ... heute bekannt, eine Lizenz- und Entwicklungsvereinbarung mit Therawis ... für die Onkologie eingegangen zu sein. Ein erstes ...
(Date:5/25/2016)... 25, 2016 According to market ... Growth and Demand Forecast to 2022 - Industry Insights ... Others)" published by P&S Market Research, the global insulin ... 2015, and it is expected to grow at a ... insulin pump segment is expected to witness the fastest ...
(Date:5/25/2016)... MedDay, a biotechnology company focused on ... presentation entitled "High doses of biotin in progressive multiple sclerosis: ... by Professor Ayman Tourbah , Principal Investigator of the ... Academy of Neurology (EAN) in Copenhagen, Denmark ... take place on Sunday, 29 May 2016 from 14:45 to ...
Breaking Medicine Technology: