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Ferritin IRMA Test

ProductsFerritin IRMA Test
Company Diagnostic Systems Laboratories, Inc.
Item Ferritin IRMA Test
Features 
  • Specific two-site IRMA, with antibodies prepared against human spleen-derived ferritin
  • Simple, one step assay
  • 30 mins + 1 hr on shaker at RT Incubation
  • Description Ferritin is the main storage protein for iron. The ferritin molecule consists of a protein shell (apoferritin) composed of heavy and light subunits, which surrounds a crystalline core containing iron oxide and phosphate [1]. Ferritin is synthesized in the liver, spleen and numerous other body tissues, with major concentrations found in the liver, spleen, bone marrow, and intestinal mucosa [1,2]. Ferritin may comprise as much as 20% of spleen dry weight. In addition to serving as a major iron storage pool, ferritin may have a protective effect against iron-induced cell damage [2,3,4].

    Low serum ferritin levels have been found to be a reliable diagnostic marker for iron-deficiency anemia, (e.g. due to nutritional iron deficiency and blood loss) [5]. In contrast, serum ferritin levels are normal or increased in anemia associated with chronic disease [6]. Measurement of serum ferritin has been advocated as a screening test for iron deficiency [7]. Elevated serum ferritin levels have been observed in acute and chronic liver disease and lymphoid malignancy (leukemia and Hodgkin lymphoma) [1,2]. High serum ferritin levels have also been associated with an elevated risk for myocardial infarction in men [8].

    1. Jacobs A & Worwood M. N Engl J Med 292: 951-956, 1975.
    2. van Eijk HG & de Jong G. Biol Trace Elem Res 35:13-24, 1992.
    3. Trenam CW, et al. J Invest Dermatol 99:675-682, 1992.
    4. Fahn S & Cohen G. Ann Neurol 32:804-812, 1992.
    5. Guyatt GH, et al. J Gen Intern Med 7:145-153, 1993.
    6. Sears DA. Med Clin North Amer 76:567-579, 1992.
    7. Herbert V. Blood Rev 6:125-132, 1992.
    8. Beard JL. Nutr Rev 51:112-115, 1993.
    Info Diagnostic Systems Laboratories, Inc.
    Customer Service: (800) 231-7970
    Web site: http://www.dslabs.com

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