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ProductsDHT RIA Test
Company Diagnostic Systems Laboratories, Inc.
Item DHT RIA Test
Description 5a-Dihydrotestosterone (DHT) is a potent naturally occurring androgen produced from testosterone through the action of cholestenone 5a-reductase [1]. The concentrations of 5a-reductase are highest in certain peripheral tissues, including genital skin and hair follicles, and are localized intra-cellularly in apparent association with the nuclear membrane. DHT exerts its biological action by intracellular binding to the androgen receptor; and this complex is then transferred to the nucleus where DNA-binding occurs with resultant effects on DNA transcription [2]. Most of the residual DHT undergoes intracellular metabolism to 3a -androstanediol and 3a -androstanediol glucuronide. Only a small proportion of DHT escapes into the peripheral circulation, where it is present primarily complexed to sex-hormone binding globulin [3].

In fetal life, testosterone causes virilization of the Wolffian ducts while DHT is responsible for the development of the male external genitalia and prostate. During male sexual maturation, DHT is primarily responsible for the physical changes

An autosomal-recessive genetic deficiency of 5 a -reductase, referred to as male pseudo-hermaphroditism or pseudo-vaginal perineoscrotal hypospadias leads to inadequate differentiation of DHT-dependent peripheral tissues. Male infants with this disorder have ambiguous genitalia and are often raised as females, although significant virilization may occur later in life presumably due to the natural increase in testosterone levels [2].

  1. Miller WL: Molecular biology of steroid hormone synthesis. Endocrin Rev 9:295-318, 1988.
  2. Pang S, Riddick L: Hirsutism. IN Lifshitz F: Pediatric Endocrinology, A Clinical Guide, second edition. Marcel Dekker, New York, 1990, pp. 259-291.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
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