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DHEA RIA Test

ProductsDHEA RIA Test
Company Diagnostic Systems Laboratories, Inc.
Item DHEA RIA Test
Features 
Description Dehydroepiandrosterone (DHEA) is produced in the adrenal cortex and, to a lesser extent, the gonads [1,2,3]. DHEA serves as a precursor in testosterone and estrogen synthesis, and has relatively weak androgenic activity, estimated at ~10% that of testosterone [1]. However, in neonates, peripubertal children and in adult women, DHEA is an important androgen as circulating DHEA levels may be several-fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgens (androstenedione and testosterone) and estrogens may occur. In addition, DHEA has a relatively low affinity for sex-hormone binding globulin. DHEA is rapidly cleared from the circulation compared to the sulfated conjugate, DHEA-S.

Measurement of serum DHEA is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in hypoadrenalism, while elevated levels occur in several conditions including virilizing adrenal adenoma and carcinoma, 21-hydroxylase and 3-hydroxysteroid dehydrogenase deficiencies and in some cases of female hirsutism [3]. Because very little DHEA is produced by the gonads, measurement of DHEA levels may aid in the localization of androgen source in virilizing conditions.

  1. Dorfman RI, Shipley RA: Androgens. John Wiley and Sons, New York, 1956, pp. 116-128.
  2. Meikle AW, et al. Endocrinol Metab Clin North Am 20:381-400, 1991.
  3. Pang S & Riddick L: Hirsutism. IN Lifshitz F (ed): Pediatric Endocrinology, A Clinical Guide, second edition. Marcel Dekker, Inc., New York, 1990, pp. 259-291.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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... special order products are offered as 1-piece ... lengths. The modular instruments may be customized ... such as ratchets, insulation and flush ports. ... stock. Customer specifications may affect delivery times. ...
... special order products are offered as 1-piece ... lengths. The modular instruments may be customized ... such as ratchets, insulation and flush ports. ... stock. Customer specifications may affect delivery times. ...
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
... Many special order products are offered ... extra long lengths. The modular instruments may ... other options such as ratchets, insulation and ... from Mediflex stock. Customer specifications may affect ...
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