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Cortisol RIA Test

ProductsCortisol RIA Test
Company Diagnostic Systems Laboratories, Inc.
Item Cortisol RIA Test
Features 
Description Cortisol is the most potent glucocorticoid produced by the human adrenal cortex. In plasma, most cortisol is bound with high affinity to corticosteroid-binding globulin (CBG), with the remainder loosely bound to albumin. Cortisol acts on specific intracellular receptors with effects in numerous physiologic systems, including immune function, glucose counter-regulation, vascular tone, substrate utilization and bone metabolism [1,2,3]. Cortisol is excreted in urine in an unbound (free) form. Cortisol levels follow a ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. Increased amounts of ACTH and cortisol are also secreted independently of the circadian rhythm in response to physical and psychological stress [4,5]. Elevated cortisol levels and lack of diurnal variation have been identified in patients with Cushings disease (ACTH hypersecretion) [2,6]. Elevated circulating cortisol levels have also been identified in patients with adrenal tumors [7]. Low cortisol levels are found in conditions of primary adrenal insufficiency and in ACTH deficiency [1,2,8,9].

References

  1. Drucker S & New MI. Pediatr Clin North Am 34:1055-1066, 1987.
  2. Migeon CJ & Lanes RL: Adrenal cortex: hypo- and hyperfunction. IN Lifshitz F (ed): Pediatric Endocrinology, A Clinical Guide, 2nd ed. Marcel Dekker, Inc., New York, 1990, pp. 333-352.
  3. Hyams JS & Carey DE. J Pediatr 113:249-254, 1988.
  4. Kreiger DT. J Steroid Biochem 6:785-791, 1975.
  5. Chernow B, et al. Arch Intern Med 147:1273-1278, 1987.
  6. Crapo L. Metabolism 28:955-977, 1979.
  7. Lee PDK, et al. Pediatrics 76:437-444, 1985.
  8. Leisti S, et al. Pediatr Res 17:861-867, 1983.
  9. Alsever RN & Gotlin RW: Handbook of Endocrine Tests in Adults and Children, 2nd ed. Year Book Medical Publishers, Inc., Chicago, 1978.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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