Navigation Links
Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-48 Myeloperoxidase

ProductsAnti-MPO ANCA EIA Auto-Immune Markers 013-MPO-48 Myeloperoxidase
Company ALPCO Diagnostics
Item Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-48 Myeloperoxidase
Features 
Description The Immunoscan MPO-ANCA Kit is an enzyme immunoassay (EIA) kit for the in vitro detection in human serum of the subclass of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) directed against myeloperoxidase to be used as an aid in the diagnosis of crescentic glomerulonephritis. ANCA are a family of autoantibodies associated with vasculitic disorders and glomerulonephritis (GN). They were first described in 1982 in patients with necrotizing GN (1) and in patients with vasculitis and GN in 1984 (2). In 1985 research on Wegeners granulomatosis (WG), independent from the earlier observations, described detection of ANCA (also called ACPA) as a diagnostic tool for Wegeners granulomatosis (3,4). In the efforts to identify the antigens for ANCA it was found that two staining patterns for ANCA could be described by indirect immunofluorescence (IIF) using ethanol fixed human neutrophils (5). One subclass of ANCA gave a finely granular, diffuse staining pattern of the cytoplasm of human neutrophils. At the 2nd International Workshop on ANCA, this subclass was termed c-ANCA for cytoplasmic staining or classical staining ANCA, and correlated to the ACPA associated with Wegeners granulomatosis (6,7). It had been shown that c-ANCA were directed against an antigen in the azurophil granules of the cytoplasm of human neutrophils (8) and later that the principal antigen was a 29kD serine protease identical to proteinase 3 or myeloblastin (9,10,11). When detected by antigen specific assays these autoantibodies are termed 29kD-ANCA or PR3-ANCA. The other subclass of ANCA yielded a perinuclear staining pattern. This was originally thought to represent granulocyte-specific anti-nuclear antibodies (GS-ANA) (5) but in sera from patients with GN such autoantibodies were shown to be due to ANCA directed against myeloperoxidase (MPO), also present in the azurophil granules in the cytoplasm of neutrophils (6,12). These antibodies were termed p-ANCA due to the perinuclear staining when detected by IIF and are termed MPO-ANCA when detected by antigen specific assays.
Info ALPCO DiagnosticsCall ALPCO Diagnostics to buy products (US and Canada only; other locations use number below) USACanada1-866-466-7731

Customer Service: (800) 592-5726
Web site: http://www.alpco.com

Related medicine products :

1. Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-96 Myeloperoxidase
2. Anti-MPO - ELISA (P-ANCA)
3. CIC (C1-q) EIA Auto-Immune Markers 001-EK-CIC Circulating Immune Complexes
4. GBM -Ab EIA Auto-Immune Markers 013-GBM-96 Glomerular Basement Membrane
5. Anti-PR3 EIA Auto-Immune Markers 013-PR3-48 Proteinase
6. Anti-PR3 EIA Auto-Immune Markers 013-PR3-96 Proteinase
7. GBM -Ab EIA Auto-Immune Markers 013-GBM-48 Glomerular Basement Membrane
8. ENA Screen EIA Auto-Immune Markers 012-MDKES1 Extractable Nuclear Antigens
9. Surgical Markers
10. TLS Surgical Markers
11. SQUEEZE-MARK Surgical Markers
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
... 5mm AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
Medicine Products:
(Date:2/5/2016)... NY (PRWEB) , ... February 05, 2016 , ... ... partners and setting the stage for new clinical and scientific initiatives have all ... year after she was appointed President and CEO of the nation’s oldest cancer ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President ... have signed a joint enrollment and degree completion agreement. The agreement, which ... baccalaureate degrees at FHU|Dickson. , The agreement allows students to be jointly ...
(Date:2/5/2016)... ... February 05, 2016 , ... The American public tends to feel uncomfortable about ... than regular municipal or well water. The recent experience with lead contaminated water in ... a long way toward increasing public acceptance of recycled waste water as drinking water. ...
(Date:2/5/2016)... ... February 05, 2016 , ... At its annual meeting held last week, ... of the National Board of Directors. Mr. McDermott succeeds former APDA Chairman, Fred Greene. ... Leslie A. Chambers , APDA President and CEO. “Pat has tirelessly served APDA since ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the ... a dream. A hallmark feature of patients with eating disorders is significant self-criticism, and ... disorder behaviors and obsessions are regarded as maladaptive means for coping with this unease, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , February 5, 2016 ... Today, VoicePower Ltd - The Speech Recognition People, announced their ... deployed to improve patient care, reduce turnaround times and to save ... CCG ,- VoicePower client since 2013 Challenge: --> ... Challenge: --> - Six doctors ,- Wirral CCG ,- ...
(Date:2/4/2016)... 4, 2016  The Senior Care Pharmacy Coalition ... Committee Chairman Jason Chaffetz (R-UT) and ... hearing , "Developments in the Prescription Drug ... growing questions about abusive pharmacy benefit manager (PBM) ... and Ranking Member Elijah Cummings (D-MD) are diligent, ...
(Date:2/4/2016)...  Montoya Love is recognized by Continental Who,s Who ... Montoya is the Regulatory Systems Operations Manager with ... Manufacturing and selling a broad range of ... healthcare institutions, clinical laboratories and life science researchers with ... globe. ...
Breaking Medicine Technology: