|Products||Androstenedione RIA Test|
|Company||Diagnostic Systems Laboratories, Inc.|
|Item||Androstenedione RIA Test|
|Description|| Androstenedione, produced in the adrenal gland and gonads, is the immediate precursor to both testosterone and estrone, both of which may be subsequently converted to estradiol. Androstenedione has relatively weak androgenic activity, estimated at ~(less than or equal to) 20% of testosterone . However, serum androstenedione levels often exceed testosterone in both normal and disease states. Secretion and production rates also exceed those of testosterone in women in whom significant extra-adrenal conversion of androstenedione to testosterone occurs [1,2,3].
Measurement of serum androstenedione provides a useful marker of androgen biosynthesis. Elevated androstenedione levels have been demonstrated in virilizing congenital adrenal hyperplasia . Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hyperthecosis, 3b-hydroxysteroid dehydrogenase deficiency, and other causes of hirsutism in women [3,5]. Elevated serum androstenedione levels may also occur in adrenal and ovarian virilizing tumors .
|Info|| Diagnostic Systems Laboratories, Inc.|
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Web site: http://www.dslabs.com