|Products||Androstanediol Glucuronide RIA Test|
|Company||Diagnostic Systems Laboratories, Inc.|
|Item||Androstanediol Glucuronide RIA Test|
|Description|| Androstanediol glucuronide (3alpha-diol G) is the glucuronide conjugate of 3alpha-androstanediol, a major metabolite of dihydrotestosterone (DHT) [1,2]. 3alpha-diol G has strong androgenic activity estimated at 75% of the bioactivity of testosterone . Serum 3alpha-diol G is the product of intracellular reduction of DHT, and in addition, a significant proportion of serum 3alpha-diol G is derived from DHEA-Sulfate and androstenedione.
Elevated levels of serum 3alpha-diol G have been reported in congenital adrenal hyperplasia [3,4] and in various forms of female hirsutism [1,5,6], e.g. idiopathic hirsutism and polycystic ovary disease. Serum 3alpha-diol G may be elevated in the presence of normal levels of other circulating androgens [1,5,6]. Therefore, measurement of serum 3alpha-diol G levels may be useful in the clinical evaluation and management of hirsutism and other conditions with excessive adrenal androgen production.
1. Rittmaster RS. Endocrin Rev 14:121-132, 1993.
|Info|| Diagnostic Systems Laboratories, Inc.|
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