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ALS, Total ELISA Test

ProductsALS, Total ELISA Test
Company Diagnostic Systems Laboratories, Inc.
Item ALS, Total ELISA Test
Features 
Description Acid-labile subunit (ALS) is a GH dependent protein which is produced in the liver as a 578 amino acid peptide with a predicted molecular weight of 63.3 kDa. IGFs in human serum are mostly confined to a ~150 KDa GH-dependent ternary protein complex consisting of IGFBP-3, a molecule of IGF-I or IGF-II, and this unique acid-labile subunit (ALS) [1-6]. The first description of ALS was based on the observation that acidification would result in dissociation of the 150 KDa complex into acid-stable IGF (~7.5 KDa) and IGFBP-3 (~50 KDa) components while neutralization of the acidified sample would no longer support formation of the 150 KDa complex [7,8]. The existence of ALS was later confirmed by the finding that serum-derived ALS could readily convert binary IGF/IGFBP-3 complexes to the 150 KDa form and that IGFBP-3 occupancy by IGF-I or IGF-II was a prerequisite for the complex assembly [9,10] in vivo. However, ALS may also be capable of IGF-independent interaction with IGFBP-3 and as such modulate the binding capacity of IGFBP-3 for the IGF peptides [11].

  1. Jones JI et al. Endocrin Rev 16:3-34, 1995
  2. Rosenfeld RG et al. Recent Prog Horm Res 46:99-163, 1990
  3. Shimesaki S et al. Prog Growth Factor Res 1:243-266, 1991
  4. Lamson C et al. Growth Factors 5:19-28, 1991
  5. Holly JMP et al. Growth Regul 4(suppl 1):20-30, 1994
  6. Cohen P et al. Curr Opin Pediatr 6:462-467, 1994
  7. Furlanetto RM J Clin Endocrinol Metab 51:12-19, 1980
  8. Hintz RL et al in Growth hormone and other biologically active peptides. Amsterdam: Excerpta Medica 1980;133-143
  9. Baxter RC Clin Endocrinol Metab 67:265-272, 1988
  10. Baxter RC et al. J Biol Chem 264:11843-11848, 1989
  11. Barreca A et al. J Clin Endocrinol Metab 80:1318-1324, 1995.
Info Diagnostic Systems Laboratories, Inc.
Customer Service: (800) 231-7970
Web site: http://www.dslabs.com

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... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
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