|Products||ACTH RIA Test|
|Company||Diagnostic Systems Laboratories, Inc.|
|Item||ACTH RIA Test|
|Description|| ACTH (adrenocorticotropic hormone) is synthesized in the pars distalis of the anterior pituitary gland and is secreted into the peripheral circulation, where it has a half-life of approximately 20 minutes . ACTH is secreted in response to corticotropin-releasing factor (CRF) from the hypothalamus . The actions of CRF are augmented by arginine vasopressin. Several other stimulatory and inhibitory factors, including catecholamines and cytokines, may also play an important role in ACTH secretion. Both CRF and ACTH production and secretion are directly inhibited by glucocorticoids [1,2]. ACTH stimulates adrenal steroidogenesis, mainly cortisol production, but also aldosterone and adrenal androgen synthesis. Decreased ACTH secretion can occur in a variety of pituitary and hypothalamic disorders and in certain systemic infections. Elevated plasma levels are observed in patients with ACTH-secreting pituitary (Cushings disease) and non-pituitary (especially lung) tumors and in primary adrenal disorders affecting cortisol secretion. Increased ACTH secretion is also observed in pregnancy, during the menstrual cycle and stress.
|Info|| Diagnostic Systems Laboratories, Inc.|
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