Navigation Links
p53, the Guardian of Our Genome

p53 is a tumor suppressor gene which was identified by Professor Sir David Lane of Dundee University in 1970.//

Experiments done on this gene using the mice model shows that the gene keeps cancer at bay and also alters the ageing process. Larry Donehower of Baylor College of Medicine in Houston created some mice without the gene and found that they later developed cancer. In another set he modified the gene and the mice were protected against cancer but aged exceptionally fast. This study proved that ageing and cancer are related and are the two sides of the same coin. This discovery raises two important and alarming questions. One, whether treatments for cancer could accelerate ageing in the patient and result in dementia, later? Secondly drugs used to prevent ageing in people increase their risk of cancer? Further research is needed to answer these questions.

Some of the facts that are known about the gene are that produces a 53,000 molecular weight protein when it is active. It is activated when it senses DNA damage. It prevents the cell from reproducing until the DNA is repaired, or it induces cell death. About 36,000 papers were published till date and bringing together every two years an ever-widening community of scientists working on the frontiers of cancer research to share their latest findings on this gene.

There is a rare condition, for instance, called Li-Fraumeni syndrome, where people are born with mutant p53 in all their cells. Affected individuals are extremely vulnerable to cancer, tending to develop tumors. p53 is kept under tight control by another gene called mdm2 that switches it on and off. Mdm2 is what stops p53 killing all our cells. Hence further research is needed to better understand the functioning of both mdm2 and p53 gene.


'"/>




Page: 1

Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. Human Diseases May Have Clue In Human-Chimp Genome Difference
3. Race Based Genome Project Launched By Mexico
4. Dog (Mans best friend) Genome Sequenced
5. Decoding the Fungi Genome Will Save Millions of Lives.
6. Yeast Genome Unravels Genes Critical For Maintaining DNA Integrity
7. Unraveling the Secrets of MHC in Human Genome
8. NHGRI Aims To Sequence Primate Genomes
9. Genome Code Cracked for Breast and Colon Cancers
10. Sea Urchin Genome Similar To Man And May Cure Diseases
11. Scientists Map Key Landmarks in Human Genome
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/18/2017)... ... August 18, 2017 , ... As an industry leader, Eppendorf ... they will present the line of epMotion automated liquid handling system. This automated ... automate everyday pipetting tasks. , Ideal for scientists and lab technicians with no ...
(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh ... protection assistance to communities in North-Central West Virginia, is embarking on a cooperative ... boys in the area. , The Chestnut Mountain Ranch (CMR) is a Christ-centered ...
(Date:8/18/2017)... IN (PRWEB) , ... August 18, 2017 , ... The ... communities in northwest Indiana, is campaigning in support of Campagna Academy in a charity ... to as the “Hoosier Boys’ Town of Indiana,” Campagna Academy is a nonprofit organization ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Emotions are sacred, valid, honored, encouraged. This ... positive education company Generation Mindful. To help change the mindset of parents and educators ... skills, she created the Time-In Toolkit, which launched on Kickstarter 3 weeks ago and ...
(Date:8/18/2017)... ... August 18, 2017 , ... Alcovit, a lime-flavored beverage that rids the ... efforts with its product now available through Jet.com. , After 25 years of ... powdered drink is designed to quickly detox the body thereby avoiding alcohol-induced hangovers. Whether ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... Second-quarter 2017 revenues of $876 ... from continuing operations Second-quarter ... $110 million Second-quarter 2017 ... Second-quarter 2017 adjusted diluted ... percent to $0.93 Second-quarter ...
(Date:8/7/2017)...  Endo International plc (NASDAQ: ENDP ) ... all known U.S. mesh product liability claims and that ... remaining U.S. claims at reasonable values. Under the agreements, ... quarter of 2017 and continuing through the fourth quarter ... results, the Company intends to increase its mesh product ...
(Date:8/2/2017)... and BENTON, Ky. , Aug. 2, 2017   Marshall County ... its environmental services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The ... disinfection robot that uses UVC light energy to kill deadly pathogens such as C. ... Tru-D SmartUVC ... Tru-D in action in ...
Breaking Medicine Technology: