Navigation Links
microRNA And Its Role In Synaptic Regulation

microRNA belong to the non-coding region of the genome. They play a very important role in regulating the other gene activities like synapses. Researchers at Children's Hospital, Boston says that they are involved in the development of the nervous system.// Synapses are the junctions where the brain cells communicate with each other. This region is very important in the process of developing learning and memory. The findings of this research were published in the journal Nature.

Michael Greenberg, PhD, Director of Neuroscience at Children's Hospital Boston said that this research is one of a kind that helps us to probe into the new mechanism of gene regulation and expression.

Brain has the ability to make or break new synapses thereby adapting itself to the changing environment. It helps in the strengthening the new synaptic junctions and breaking the old unnecessary ones.

Greenberg experimented with animal models such as the rat said that miR-134 (microRNA) helps in altering the size of dendritic spines. Synapses occur at the junction of these dendrites. miR-134 decreases the spine size and weakens the synapse. When miR-134 was inhibited, spines increased in size, strengthening the synapse.

miR-134 is responsible for the inhibition of a gene, Limk1. This causes the growth of the dendritic spines. When neurons were exposed to a growth factor, brain-derived neurotrophic factor (BDNF), Limk1 became active again, enhancing spine growth.

Greenberg believes that the microRNA are responsible in controlling synaptic development. A single neuron can give rise to thousands of synapses. He says that it is very important to be able to control the activities at one synaptic junction without altering the activities at another junction. By doing so a person has the ability to store more information and have increased computational capacity in the brain.

He thinks that this discovery can be put to use in case of treati ng disorders such as mental retardation and autism. It is found that deletion of Limk1 gene is associated with Williams syndrome, and that the alteration of the BDNF pathway all are found in case of patients suffering from tuberous sclerosis and Fragile X syndrome. Research is proved that these three disorders lead to mental retardation and compromised cognition.


'"/>




Related medicine news :

1. Cancer diagnosis easier from microRNA
2. Platelets May Be The Source Of Gene Regulations
3. Novel Rules And Regulations For Cardiovascular Catheterization Labs.
4. Nervous System Plays Role In Stem Cell Regulation
5. Bill for Formal Regulation of Tanning Salons
6. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
7. WHO Calls For More Regulation On Tobacco Products
8. Site of Sleep Regulation Identified in Fruit Flies
9. Mechanism of Stem Cell Regulation Identified
10. Natural Approach to Immune Regulation May Help Transplant Patients
11. Regulation of Infertility Clinics Needed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... California (PRWEB) , ... May 28, 2016 , ... "Color ... to drag and drop a preset onto their media," said Christina Austin - CEO ... Film Studios, editors can quickly and easily add stylish color grades to their footage. ...
(Date:5/27/2016)... ... 27, 2016 , ... More than a third of American adults are considered ... surgery has received increased attention in recent years, as an article published ... weight loss, most people are familiar with the basic requirements of maintaining a healthy ...
(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses and ... to shed lights on the variety of topics detailing why we appreciate nurses in ... why this career has gone from being in a major recession to one of ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... help educate the many who are unaware of the plight of aphasia. In ... run within the “Stroke Awareness” campaign. , The link between stroke and aphasia ...
(Date:5/27/2016)... PALMYRA, Wis. (PRWEB) , ... May 27, 2016 ... ... over $90,000 in scholarships to students studying complementary medicine. Allison Outerbridge is this ... She accepted her award on May 18 at the university’s Student Leadership Awards ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Germany and GERMANTOWN, Maryland , ... QGEN ; Frankfurt Prime Standard: QIA) today announced ... agreement with Therawis Diagnostics GmbH to develop and commercialize predictive ... and market PITX2 as a marker to predict effectiveness of ... patients. "We are pleased to partner with Therawis, ...
(Date:5/25/2016)... 25, 2016 As illustrated by ... this month, the numbers and momentum of cannabis in ... into the billions, more research and development push the ... State of Legal Marijuana Markets Report  from from ArcView ... much of the increase in sector is attributed to ...
(Date:5/25/2016)... CAMBRIDGE, England , May 25, 2016 /PRNewswire/ ... genomics company employing the precision of circulating tumour ... oncology, today announces the appointment of Professor ... will provide medical leadership across the clinical development ... that Inivata,s products help deliver significant improvements in ...
Breaking Medicine Technology: