Navigation Links
microRNA And Its Role In Synaptic Regulation

microRNA belong to the non-coding region of the genome. They play a very important role in regulating the other gene activities like synapses. Researchers at Children's Hospital, Boston says that they are involved in the development of the nervous system.// Synapses are the junctions where the brain cells communicate with each other. This region is very important in the process of developing learning and memory. The findings of this research were published in the journal Nature.

Michael Greenberg, PhD, Director of Neuroscience at Children's Hospital Boston said that this research is one of a kind that helps us to probe into the new mechanism of gene regulation and expression.

Brain has the ability to make or break new synapses thereby adapting itself to the changing environment. It helps in the strengthening the new synaptic junctions and breaking the old unnecessary ones.

Greenberg experimented with animal models such as the rat said that miR-134 (microRNA) helps in altering the size of dendritic spines. Synapses occur at the junction of these dendrites. miR-134 decreases the spine size and weakens the synapse. When miR-134 was inhibited, spines increased in size, strengthening the synapse.

miR-134 is responsible for the inhibition of a gene, Limk1. This causes the growth of the dendritic spines. When neurons were exposed to a growth factor, brain-derived neurotrophic factor (BDNF), Limk1 became active again, enhancing spine growth.

Greenberg believes that the microRNA are responsible in controlling synaptic development. A single neuron can give rise to thousands of synapses. He says that it is very important to be able to control the activities at one synaptic junction without altering the activities at another junction. By doing so a person has the ability to store more information and have increased computational capacity in the brain.

He thinks that this discovery can be put to use in case of treati ng disorders such as mental retardation and autism. It is found that deletion of Limk1 gene is associated with Williams syndrome, and that the alteration of the BDNF pathway all are found in case of patients suffering from tuberous sclerosis and Fragile X syndrome. Research is proved that these three disorders lead to mental retardation and compromised cognition.


'"/>




Related medicine news :

1. Cancer diagnosis easier from microRNA
2. Platelets May Be The Source Of Gene Regulations
3. Novel Rules And Regulations For Cardiovascular Catheterization Labs.
4. Nervous System Plays Role In Stem Cell Regulation
5. Bill for Formal Regulation of Tanning Salons
6. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
7. WHO Calls For More Regulation On Tobacco Products
8. Site of Sleep Regulation Identified in Fruit Flies
9. Mechanism of Stem Cell Regulation Identified
10. Natural Approach to Immune Regulation May Help Transplant Patients
11. Regulation of Infertility Clinics Needed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Surgical Procedure Volumes: Global Analysis (United States, ... Australia, Canada)" report to their offering. ... an essential tool for healthcare business planners, provides surgical ... looks at surgery trends with an in-depth analysis of ...
(Date:6/23/2016)... YORK , June 23, 2016 ... waters, but it continues to present great opportunities to ... companies for today: Intrexon Corp. (NYSE: XON ... Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), and ... more about these stocks and receive your complimentary trade ...
(Date:6/23/2016)... DIEGO , June 23, 2016 ... programs that address medical conditions resulting from a ... it has appointed Greg Doyle as ... of Leading BioSciences, executive management team and board ... and chief financial officer. He will provide continued ...
Breaking Medicine Technology: