Navigation Links
Zinc – A New Key Player In Brain Circuitr

The new findings of a study shed light on a nagging mystery in neurobiology: why the connections among certain types of neurons contain// considerable pools of free zinc ions. Zinc - a new key player adds to the multitude of substances that regulate neuronal signaling in the brain and spinal cord – says the research.

By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons. Significantly, they found the mutant mouse shows the same exaggerated response to noise as children with the genetic disorder called "startle disease," or hyperekplexia.

The findings shed light on a nagging mystery in neurobiology: why the connections among certain types of neurons contain considerable pools of free zinc ions. And even though many studies had shown that zinc could act toxically on transmission of neural impulses, half a century of experiment researchers had not been able to show conclusively that the metal plays a role in normal nerve cell transmission.

However, in an article in the November 22, 2006, issue of the journal Neuron, published by Cell Press, Heinrich Betz and colleagues conclusively demonstrate just such a role for zinc.

In their experiments, the researchers produced mice harboring a mutant form of a gene for a receptor for zinc in neurons--thereby compromising the neurons' ability to respond to zinc. The mutation in the receptor, called the glycine receptor, targets the same receptor known to be mutated in humans with hyperekplexia. The receptor functions as a modulator of neurons in both motor and sensory signaling pathways in the brain and spinal cord.

The genetic approach used by the researchers was a more targeted technique than previous experiments in which researchers reduced overall neuronal zinc levels using chemicals called chelators that soak up zinc ions.

The resulting mutant mice showe d tremors, delayed ability to right themselves when turned over, abnormal gait, altered transmission of visual signals, and an enhanced startle response to sudden noise.

Electrophysiological studies of the mutant animals' brain and spinal neurons showed significant zinc-related abnormalities in transmission of signals at the connections, called synapses, among neurons.

Betz and his colleagues wrote, "The data presented in our paper disclose a pivotal role of ambient synaptic [zinc ion] for glycinergic neurotransmission in the context of normal animal behavior." They also concluded that their results implied that manipulating synaptic zinc levels could affect the neuronal action of zinc, but that such manipulation "highlights the complexity of potential therapeutic interventions," which could cause an imbalance between the excitatory and inhibitory circuitry in the central nervous system.

In a preview of the paper in the same issue of Neuron, Alan R. Kay, Jacques Neyton, and Pierre Paoletti wrote "Undoubtedly this work is important, since it directly demonstrates that zinc acts as an endogenous modulator of synaptic transmission." They wrote that the findings "will certainly revive the flagging hopes of zincologists. This work provides a clear demonstration that interfering with zinc modulation of a synaptic pathway leads to a significant alteration in the phenotype of the animal." The three scientists added that the finding "puts a nice dent in the zinc armor, which held firm for more than 50 years."



Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Teen Players Urged To Wear Helmets and Gloves to Avoid Sports Injuries
2. Jharkhand Ropes in Private Players for Health Scheme
3. Researchers Uncover Critical Player in Cell Communication
4. The Cause Behind Water Polo Players’ Sickness Remains A Myster
5. Body Composition Is Key Player in Controlling Cancer Risks
6. Modified Ligament Surgery Improves Outcomes Players, Athletes
7. Indias Pharmaceutical Industry to Be Global Player: Study
8. Former Official Confesses He Had Sold Steroids to Leading Baseball Players
9. Ex Pro-football Players Saddled With Depression After Retirement
10. Use of Cellular Phones associated with Increased risk of Brain Tumors
11. Brain death – How to cope with it
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... 19, 2017 , ... Remote Medical Technologies (RMT), the leader ... with their iMedHD2™ Portable Teleultrasound System. Compatible with any ultrasound ... HD, dynamic, streaming ultrasound images and video to one or more distant locations ...
(Date:1/19/2017)... City, Utah (PRWEB) , ... January 19, 2017 ... ... Film Festival in a medical capacity this year. Drs. Alexander Paziotopoulos, Andrew Petersen ... to provide a condensed version of the clinic’s leading recovery program. , ...
(Date:1/19/2017)... , ... January 19, 2017 , ... ... by the American Board of Dermatology and fellowship trained Mohs and cosmetic surgeon. ... Institutes of Health, Dr. Li completed his internship in internal medicine at the ...
(Date:1/19/2017)... ... January 19, 2017 , ... Bio-Optronics ... provides a modern CTMS workflow designed to seamlessly integrate and streamline the way ... to a single page, maximizing usability and improving efficiency significantly for users – ...
(Date:1/19/2017)... San Antonio, Texas (PRWEB) , ... January 19, 2017 , ... ... entering the GenCure Tissue Donation Awareness Scholarship competition., The winner will earn a $1,000 ... media accounts. The competition begins Feb. 1, and the deadline is May 31, with ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... YORK , Jan. 19, 2017 This ... the current and future scenario of the global market. ... rising opioid consumption. Severe chronic constipation is a major ... to traditional laxatives. Hence, novel targeted therapy has been ... OIC sufferers, launch of targeted medicines, and growing awareness ...
(Date:1/19/2017)... January 19, 2017 According to a study ... is set to witness a CAGR of 6.5% during the forecast ... will continue to be the leading market for cryotherapy globally ... ... emphasizing on ensuring affordable and adequate supply of gas in order ...
(Date:1/19/2017)... , Jan. 19, 2017  Sensus Healthcare, Inc. ... company specializing in the treatment of non-melanoma skin ... with superficial radiation therapy, today announced that it ... 2016 financial results on Thursday, February 2, 2017 after ... hold a conference call with the investment community ...
Breaking Medicine Technology: