Navigation Links
Zinc – A New Key Player In Brain Circuitr

The new findings of a study shed light on a nagging mystery in neurobiology: why the connections among certain types of neurons contain// considerable pools of free zinc ions. Zinc - a new key player adds to the multitude of substances that regulate neuronal signaling in the brain and spinal cord – says the research.

By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons. Significantly, they found the mutant mouse shows the same exaggerated response to noise as children with the genetic disorder called "startle disease," or hyperekplexia.

The findings shed light on a nagging mystery in neurobiology: why the connections among certain types of neurons contain considerable pools of free zinc ions. And even though many studies had shown that zinc could act toxically on transmission of neural impulses, half a century of experiment researchers had not been able to show conclusively that the metal plays a role in normal nerve cell transmission.

However, in an article in the November 22, 2006, issue of the journal Neuron, published by Cell Press, Heinrich Betz and colleagues conclusively demonstrate just such a role for zinc.

In their experiments, the researchers produced mice harboring a mutant form of a gene for a receptor for zinc in neurons--thereby compromising the neurons' ability to respond to zinc. The mutation in the receptor, called the glycine receptor, targets the same receptor known to be mutated in humans with hyperekplexia. The receptor functions as a modulator of neurons in both motor and sensory signaling pathways in the brain and spinal cord.

The genetic approach used by the researchers was a more targeted technique than previous experiments in which researchers reduced overall neuronal zinc levels using chemicals called chelators that soak up zinc ions.

The resulting mutant mice showe d tremors, delayed ability to right themselves when turned over, abnormal gait, altered transmission of visual signals, and an enhanced startle response to sudden noise.

Electrophysiological studies of the mutant animals' brain and spinal neurons showed significant zinc-related abnormalities in transmission of signals at the connections, called synapses, among neurons.

Betz and his colleagues wrote, "The data presented in our paper disclose a pivotal role of ambient synaptic [zinc ion] for glycinergic neurotransmission in the context of normal animal behavior." They also concluded that their results implied that manipulating synaptic zinc levels could affect the neuronal action of zinc, but that such manipulation "highlights the complexity of potential therapeutic interventions," which could cause an imbalance between the excitatory and inhibitory circuitry in the central nervous system.

In a preview of the paper in the same issue of Neuron, Alan R. Kay, Jacques Neyton, and Pierre Paoletti wrote "Undoubtedly this work is important, since it directly demonstrates that zinc acts as an endogenous modulator of synaptic transmission." They wrote that the findings "will certainly revive the flagging hopes of zincologists. This work provides a clear demonstration that interfering with zinc modulation of a synaptic pathway leads to a significant alteration in the phenotype of the animal." The three scientists added that the finding "puts a nice dent in the zinc armor, which held firm for more than 50 years."



Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Teen Players Urged To Wear Helmets and Gloves to Avoid Sports Injuries
2. Jharkhand Ropes in Private Players for Health Scheme
3. Researchers Uncover Critical Player in Cell Communication
4. The Cause Behind Water Polo Players’ Sickness Remains A Myster
5. Body Composition Is Key Player in Controlling Cancer Risks
6. Modified Ligament Surgery Improves Outcomes Players, Athletes
7. Indias Pharmaceutical Industry to Be Global Player: Study
8. Former Official Confesses He Had Sold Steroids to Leading Baseball Players
9. Ex Pro-football Players Saddled With Depression After Retirement
10. Use of Cellular Phones associated with Increased risk of Brain Tumors
11. Brain death – How to cope with it
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... Sacramento, CA (PRWEB) , ... December 06, 2016 , ... ... travel can disrupt daily routines. That means it's also the season when eating healthy, ... those living with diabetes) on schedule is harder to do. , "Shopping trips, ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: ... powerful woman's story of sacrifice and enlightenment. , “Tatiana Sibirskaya: A ... Fryer. Always looking for creative outlets, Carolyn gravitated toward writing through the inspiration ...
(Date:12/6/2016)... ... 06, 2016 , ... TopConsumerReviews.com recently gave a best-in-class 5 star rating to ... give freedom to people who need help getting around. For some, advancing age has ... period of rehabilitation after an illness or accident. There is a wide variety of ...
(Date:12/6/2016)... California (PRWEB) , ... December 06, 2016 , ... "Add ... users to flicker, flash, and flare from clip to clip with high quality 4K ... , TransFlare 4K Jewel contains 44 lens flares filmed on the RED Dragon. Utilizing ...
(Date:12/5/2016)... ... , ... What: Shriners Hospitals for Children, with the help of Dimension Data, ... a video monitor and web-enabled camera. Santa visits with children through Dimension Data’s program ... Wonderland, which is where the video connection to the North Pole will stream. Much ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016  Balloon catheter is ... which is inserted into the femoral artery in the ... arm to treat constricted blood vessels. These products are ... to atherosclerosis – deposition of lipid substances in the ... catheter market is projected to expand at a CAGR ...
(Date:12/5/2016)... , Dec. 5, 2016 Spain Glaucoma Surgery ... new report, "Spain Glaucoma Surgery Devices Market Outlook to ... Surgery Devices market. The report provides value, in millions ... (USD) within market segements - Canaloplasty Micro Catheters and ... shares and distribution shares data for each of these ...
(Date:12/5/2016)... 5, 2016  Cornerstone Pharmaceuticals, Inc., a privately ... from two Phase I trials evaluating its lead ... annual meeting of the American Society of Hematology ... . The two datasets show encouraging efficacy and ... (AML) and T-cell non-Hodgkin,s lymphoma (T-cell NHL), respectively, ...
Breaking Medicine Technology: