Navigation Links
Yale Researchers Named Ellison Foundation Senior Scholars in Aging

New Haven, Conn. — Two distinguished Yale scientists have been named Senior Scholars in Aging research by the Ellison Medical Foundation, a four-year award made// to established investigators for research into understanding development processes that affect lifespan, and age-related diseases and disabilities.

Named at Yale are Frank J. Slack, associate professor of molecular, cellular and developmental biology, and Sandra L. Wolin, professor of cell biology and of molecular biophysics & biochemistry.

Frank Slack studies the genetic switches that control development, and “aging” as a developmental process. According to Slack, “Changes in gene expression in aged adults — across many species — do not solely seem to be a response to mounting cellular damage. Rather, a conserved, developmentally-timed regulation of gene activity during young adulthood seems to control features of aging.”

Past research on C. elegans and Drosophila, laboratory round worms and fruit flies, demonstrated that in early adulthood these animals turn off a conserved group of genes that mobilize energy from food, and turn on stress response genes. There is a similar trend in human brain tissue, where the switch occurs at around age 40, implying that aging, or specifically the time of death, is under a timed control at the genetic level.

“We found that genes that regulate the timing of events during C. elegans development also regulate timing of aging and death during adulthood,” said Slack. Consistent with the lifespan analysis, mutants he studied were stress-sensitive and aged prematurely. Since some of these genes coded for small non-coding RNAs called microRNAs, his work provided some of the best evidence for a novel role for microRNAs in aging, and opened the potential of using microRNAs to regulate human health during aging.

Slack joined the Yale faculty in 2000 after completing his undergraduate work in microbiology, biochemistry and molecu lar genetics at the University of Cape Town, his doctoral work in molecular biology at Tufts University and post-doctoral training at Stanford University School of Medicine and Harvard University. He is also a member of the Yale Cancer Center.

Sandra Wolin will determine how RNA damage that occurs because of normal cellular activity contributes to aging. She is studying how RNA molecules fold into intricate structures inside cells and how cells recognize misfolded RNAs. “In both mammalian cells and yeast, we focus on proteins and RNA-protein complexes that play critical roles in these processes,” said Wolin. “Our work has revealed unexpected connections between RNA misfolding, radiation damage repair and autoimmune disease.”

Damaged RNAs have often been detected in the brains of aging animals and patients with neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. However, because the cellular pathways for recognizing and degrading these RNAs are unknown, it has not been possible to determine whether RNA damage contributes to aging or to age-related diseases. Under this program, Wolin will identify genes involved in detecting and degrading damaged RNAs and determine whether they contribute to senescence.

“Once we have identified these important genes in yeast, we will determine whether the same components are involved in this process in mouse and human cells,” said Wolin. “We will also determine whether the failure to degrade damaged RNAs contributes to senescence in mouse and human cells. Knowing how RNA damage contributes to aging or to neurodegeneration could be of broad importance for designing therapeutics that slow the aging process.”

Wolin joined the Yale faculty in 1991. After undergraduate work in biochemistry at Princeton University, she received both an M.D. degree and a Ph.D. in molecular biophysics and biochemistry from Yale University, and then completed her postdoctoral training a t the University of California, San Francisco. She is also a member of the Yale Cancer Center.

The Ellison Medical Foundation Senior Scholar program in Aging brings an award of $150,000 per year over the four years to support established investigators in the development of new and creative research programs. According to Executive Director Richard L. Sprott, “The Ellison Medical Foundation’s goal is to provide scientists with the resources, freedom, and flexibility to pursue high-risk research that could have a scientific impact worldwide. The Foundation expects that its programs will stimulate exciting innovative research that will improve lives and influence future discoveries.”

Source-Bio-io Technology

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just announced a ... customers 10% off of their purchase of lice treatment product. In addition, customers will ... to a company spokesperson. “Finding lice is a sure way to ruin the holidays, ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions announced today that ... (MSDSLUG). Recognized as Microsoft’s official group for end users of Dynamics SL ERP ... partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing commitment ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women ... healthcare organizations in the country. They have overseen financial turnarounds, shown commitment to ... the healthcare industry as a whole through their advocacy and professional efforts. , ...
(Date:11/26/2015)... ... , ... Inevitably when people think Thanksgiving, they also think Holiday sales and ... Friday and Cyber Monday massage chair sales to receive the best pricing ... to find the best massage chair deals, they can see all of the coupons ...
(Date:11/26/2015)... ... 26, 2015 , ... PRMA Plastic Surgery is updating their record books yet ... 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the PRMA team, ... lives and it’s an honor to have served all of these women.” , PRMA ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Japanese therapeutic drug monitoring market, including ...
(Date:11/26/2015)... 2015 --> ... potential att använda SyMRI för att hitta ... patienter med multipel skleros (MS) eller hjärntumörmetastaser ... AB för att kunna använda SyMRI Research ... SyMRI kan man generera flera konstrastbilder från ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... of the "Self Administration of High Viscosity ... ) has announced the addition of ... report to their offering. --> ... the addition of the "Self Administration of ...
Breaking Medicine Technology: