Navigation Links
Y chromosome uses trick to repair its own genes

Scientists have discovered that the Y chromosome uses a neat trick to repair its most crucial genes, a strategy that apparently helps keep it from rotting away over evolutionary time.
The Y chromosome, of course, is best known for supplying the biological signal that makes males rather than females.
Some scientists have suggested it might disappear millions of years from now because it can't eliminate genetic defects in the usual way,// and broken genes tend to erode away over the long haul.

But there are reasons to be optimistic about the chromosome's future, and the new work adds one more.

"Y chromosomes really have a big trick up their sleeves," said David Page, a Howard Hughes Medical Institute investigator.

The gene-fixing trick was already known to happen occasionally in human DNA, but the surprise is that the Y chromosome has elevated it to standard operating procedure, said researchers.

The work by scientists at the Whitehead and the Washington University School of Medicine in St. Louis,is the first comprehensive and detailed analysis of the genetic code of the Y chromosome, which is best known for supplying the signal to make males.

The work is a landmark for the history of sex determination.

Scientists said followup work could illuminate basic biological differences between the sexes, perhaps shedding light on causes of differences in disease susceptibility, for example.

The Y chromosome can't fix its genes in the usual way because it doesn't meet up with other Y chromosomes. The body's other chromosomes are inherited in pairs, with one member coming from a mother and the other from a father. That pairing lets them swap corresponding pieces of themselves, a mechanism that lets the species get rid of damaged genes.

But the Y chromosome comes by itself. It can't trade appreciable amounts of DNA with its partner, the X chromosome, so it can't get rid of damaged genes that way.

The new work reports evidence that the Y chromosome makes extensive use of a process called gene conversion. The chromosome carries backup copies of its important genes, and it can use one copy to fix a flaw in the other.

The gene-fixing technique comes at a price. When the chromosome makes a mistake in the procedure, it can delete stretches of DNA. Such deletions, occuring in one in every couple thousand boys, are a recognized cause of male infertility.
'"/>




Related medicine news :

1. Disease chromosomes identified
2. Disease chromosomes identified
3. Down syndrome simulated in animal model after successful chromosome transplantation
4. Researchers trick Alzheimers Enzyme
5. Fructose is a tricker and not all that sweet!
6. Graphic warnings on cigarette packets might just do the trick!
7. Patrick Walsh Wins International Medicine Prize
8. Clotting Protein plays a role in nerve repair
9. Heart may pull Cells from Body to Self-repair
10. Bone marrow stem cells may help repair cardiac tissues
11. Bones repair themselves with bone marrow cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: