Navigation Links
Y chromosome uses trick to repair its own genes

Scientists have discovered that the Y chromosome uses a neat trick to repair its most crucial genes, a strategy that apparently helps keep it from rotting away over evolutionary time.
The Y chromosome, of course, is best known for supplying the biological signal that makes males rather than females.
Some scientists have suggested it might disappear millions of years from now because it can't eliminate genetic defects in the usual way,// and broken genes tend to erode away over the long haul.

But there are reasons to be optimistic about the chromosome's future, and the new work adds one more.

"Y chromosomes really have a big trick up their sleeves," said David Page, a Howard Hughes Medical Institute investigator.

The gene-fixing trick was already known to happen occasionally in human DNA, but the surprise is that the Y chromosome has elevated it to standard operating procedure, said researchers.

The work by scientists at the Whitehead and the Washington University School of Medicine in St. Louis,is the first comprehensive and detailed analysis of the genetic code of the Y chromosome, which is best known for supplying the signal to make males.

The work is a landmark for the history of sex determination.

Scientists said followup work could illuminate basic biological differences between the sexes, perhaps shedding light on causes of differences in disease susceptibility, for example.

The Y chromosome can't fix its genes in the usual way because it doesn't meet up with other Y chromosomes. The body's other chromosomes are inherited in pairs, with one member coming from a mother and the other from a father. That pairing lets them swap corresponding pieces of themselves, a mechanism that lets the species get rid of damaged genes.

But the Y chromosome comes by itself. It can't trade appreciable amounts of DNA with its partner, the X chromosome, so it can't get rid of damaged genes that way.

The new work reports evidence that the Y chromosome makes extensive use of a process called gene conversion. The chromosome carries backup copies of its important genes, and it can use one copy to fix a flaw in the other.

The gene-fixing technique comes at a price. When the chromosome makes a mistake in the procedure, it can delete stretches of DNA. Such deletions, occuring in one in every couple thousand boys, are a recognized cause of male infertility.
'"/>




Related medicine news :

1. Disease chromosomes identified
2. Disease chromosomes identified
3. Down syndrome simulated in animal model after successful chromosome transplantation
4. Researchers trick Alzheimers Enzyme
5. Fructose is a tricker and not all that sweet!
6. Graphic warnings on cigarette packets might just do the trick!
7. Patrick Walsh Wins International Medicine Prize
8. Clotting Protein plays a role in nerve repair
9. Heart may pull Cells from Body to Self-repair
10. Bone marrow stem cells may help repair cardiac tissues
11. Bones repair themselves with bone marrow cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... ... April 25, 2017 , ... Amendia, Inc., designer, ... its strategic partnership with and platinum sponsorship of Global Spine Outreach (“GSO”), a ... effective management of complex spine deformity cases, particularly in children. , GSO’s focus ...
(Date:4/24/2017)... Lake City, UT (PRWEB) , ... April 24, 2017 , ... ... their efforts to encourage sustainability, innovate new strategies to reduce waste, and support renewable ... herbal remedy provider. They look to nature to find solutions for health issues, and ...
(Date:4/24/2017)... , ... April 24, 2017 , ... The California Dental ... in charitable dental services to 1,961 people during the April 22-23 event at the ... charge to Californians who experience barriers to care, CDA Cares educates the public and ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... seeking public support to bring their novel lifesaving device for the everyday use ... with medical-grade sensors, specially designed to read a child’s vital signs, and detect ...
(Date:4/24/2017)... CA (PRWEB) , ... April 24, 2017 , ... ... brain tumors are expected to be diagnosed globally; approximately 25,000 of them will ... are anticipating greater use of this type of healthcare model in the diagnosis ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  AbbVie (NYSE: ... 99 percent (n=145/146) of chronic hepatitis C virus ... 5 or 6 and compensated cirrhosis (Child-Pugh A) ... (SVR 12 ) with its investigational, pan-genotypic regimen ... rates were seen following 12 weeks of G/P ...
(Date:4/20/2017)... NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical results demonstrating anti-fibrotic effects with NV556, ... (NASH), in an additional well-validated experimental NASH ... previously shown similar anti-fibrotic effects in the ... present novel data demonstrating anti-fibrotic effects of ...
(Date:4/19/2017)... Cardiology devices segment is anticipated to reach the ... Cardiology Devices segment is likely to create absolute $ opportunity ... over 2017. By the end of 2027, Cardiology Devices segment ... 700 Mn, expanding at a CAGR of 18.4% over the ... Asia Pacific reprocessed medical devices market in terms ...
Breaking Medicine Technology: