Navigation Links
Y chromosome uses trick to repair its own genes

Scientists have discovered that the Y chromosome uses a neat trick to repair its most crucial genes, a strategy that apparently helps keep it from rotting away over evolutionary time.
The Y chromosome, of course, is best known for supplying the biological signal that makes males rather than females.
Some scientists have suggested it might disappear millions of years from now because it can't eliminate genetic defects in the usual way,// and broken genes tend to erode away over the long haul.

But there are reasons to be optimistic about the chromosome's future, and the new work adds one more.

"Y chromosomes really have a big trick up their sleeves," said David Page, a Howard Hughes Medical Institute investigator.

The gene-fixing trick was already known to happen occasionally in human DNA, but the surprise is that the Y chromosome has elevated it to standard operating procedure, said researchers.

The work by scientists at the Whitehead and the Washington University School of Medicine in St. Louis,is the first comprehensive and detailed analysis of the genetic code of the Y chromosome, which is best known for supplying the signal to make males.

The work is a landmark for the history of sex determination.

Scientists said followup work could illuminate basic biological differences between the sexes, perhaps shedding light on causes of differences in disease susceptibility, for example.

The Y chromosome can't fix its genes in the usual way because it doesn't meet up with other Y chromosomes. The body's other chromosomes are inherited in pairs, with one member coming from a mother and the other from a father. That pairing lets them swap corresponding pieces of themselves, a mechanism that lets the species get rid of damaged genes.

But the Y chromosome comes by itself. It can't trade appreciable amounts of DNA with its partner, the X chromosome, so it can't get rid of damaged genes that way.

The new work reports evidence that the Y chromosome makes extensive use of a process called gene conversion. The chromosome carries backup copies of its important genes, and it can use one copy to fix a flaw in the other.

The gene-fixing technique comes at a price. When the chromosome makes a mistake in the procedure, it can delete stretches of DNA. Such deletions, occuring in one in every couple thousand boys, are a recognized cause of male infertility.
'"/>




Related medicine news :

1. Disease chromosomes identified
2. Disease chromosomes identified
3. Down syndrome simulated in animal model after successful chromosome transplantation
4. Researchers trick Alzheimers Enzyme
5. Fructose is a tricker and not all that sweet!
6. Graphic warnings on cigarette packets might just do the trick!
7. Patrick Walsh Wins International Medicine Prize
8. Clotting Protein plays a role in nerve repair
9. Heart may pull Cells from Body to Self-repair
10. Bone marrow stem cells may help repair cardiac tissues
11. Bones repair themselves with bone marrow cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
Breaking Medicine Technology: