Navigation Links
Xenotransplantation “breakthrough”,

The birth of five cloned piglets last week could significantly increase the success rate of pig-to-human organ transplantation, according to creators, PPL Therapeutics. Previous research has indicated that rejection of animal cells and organs by the human immune system is partially due to the presence of the gene alpha 1,3 galactosyl transferase. The gene codes for an enzyme that adds a sugar// to the surface of pig cells, flagging them up as foreign bodies.

A US subsidiary of PPL Therapeutics, who were also responsible for the creation of Dolly the sheep, used gene targeting to knock out a single copy of alpha 1,3 galactosyl transferase. Nuclear transfer was then used to create the five piglets.The first use of the new technology is likely to involve the production of islet cells for the treatment of diabetes. Such cells will be transplanted into primates initially, but the researchers say that human trials could start in around four years’ time.

In addition to hyperacute rejection by the human immune system, other hurdles facing xenotransplantation include delayed rejection, coagulopathy and chronic T-cell-mediated rejection. Therefore, it may be necessary to add up to three more genes to the DNA of the knock-out pigs, the scientists report.Dr Alan Colman, director of research at PPL Therapeutics, said, “With one of the major technical hurdles and scientific risks overcome, the promise of xenotransplantation is now a reality, with the potential to revolutionise the transplant industry.”

Dr Philip Dyer, President Elect of the British Transplantation Society, said, “Alpha galactosyl knockout pigs have been made before, what's new is that [PPL have] cloned them, which makes [production] easier.” He said, “Of concern is the potential risk of transmission of porcine viruses,” but added, “We would welcome any breakthrough that supports the safe and effective transplantation of animal organs to humans because of the great shortage of hum an organs for transplantation.”

'"/>




Related medicine news :

1. Innovative device aids in advanced heart failure
2. Innovative footwear may prevent fall in elderly
3. Innovative solution to help reduce the waiting times for kidney transplants
4. Personalized Medicine and Innovative Pharmaceuticals
5. Creation of Cytomegalovirus Vaccine by an Innovative Method
6. Innovative Method for Creating a Human Cytomegalovirus Vaccine Outlined
7. Innovative treatment for Dementia
8. Innovative treatment for Skin Cancer
9. Innovative Movies Show Real-Time Immune-Cell Activity within Tumors
10. Research In A New Direction To Develop Innovative Psychotropic Drugs
11. Autism Expert Creates Innovative Intervention Program
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... ... February 10, 2016 , ... Gout is like no other ... that is often severe, with intense swelling and redness. It is triggered by the ... but older adults are the most susceptible, according to the February 2016 issue of ...
(Date:2/10/2016)... ... , ... For additional information contact Phyllis Strupp 480-488-5858 , Brain improves with ... Ultimate Guide to Brain Training" by award-winning author Phyllis Strupp explains how ... March 16, 2016. A free review copy is available to the media at ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Drive, Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions - Time: ... Time: 7:00pm – 10:00pm | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org ...
(Date:2/10/2016)... Tennessee (PRWEB) , ... February 09, 2016 , ... A ... reins for Summer 2016. FHU President Joe Wiley made the announcement Monday night, Feb. ... Brad Montague, a 2003 graduate of FHU and the creator of GO! Camp, has ...
(Date:2/10/2016)... ... February 10, 2016 , ... It’s that time of year when ... president of the Interscholastic Athletic Association of Maryland (IAAM), Hall of Fame athlete and ... goals are cast aside. , That’s why one of her first decisions when her ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... REDWOOD CITY, Calif. , Feb. 9, 2016 /PRNewswire/ ... medical device company that is providing innovative evidence-based solutions ... it will release financial results for the fourth quarter ... Monday, February 29, 2016. Company management will host a ... p.m. Eastern Time) on Monday, February 29, 2016. ...
(Date:2/9/2016)... Feb. 9, 2016  Insulet Corporation (NASDAQ: PODD ) ... pump technology with its OmniPod ® ... has been appointed to Insulet,s Board of Directors. With ... eight of whom are independent. --> ... audit and finance experience and a deep knowledge of accounting, ...
(Date:2/9/2016)... 9, 2016 QGEN ... den Abschluss eines Kooperationsvertrags mit 10x Genomics ... in den Bereichen Next-Generation-Sequencing (NGS), Single-Cell-Biology und ... Frankfurt Prime Standard: QIA) gab heute den ... die Entwicklung und Förderung umfassender Lösungen in ...
Breaking Medicine Technology: