Navigation Links
Xenotransplantation “breakthrough”,

The birth of five cloned piglets last week could significantly increase the success rate of pig-to-human organ transplantation, according to creators, PPL Therapeutics. Previous research has indicated that rejection of animal cells and organs by the human immune system is partially due to the presence of the gene alpha 1,3 galactosyl transferase. The gene codes for an enzyme that adds a sugar// to the surface of pig cells, flagging them up as foreign bodies.

A US subsidiary of PPL Therapeutics, who were also responsible for the creation of Dolly the sheep, used gene targeting to knock out a single copy of alpha 1,3 galactosyl transferase. Nuclear transfer was then used to create the five piglets.The first use of the new technology is likely to involve the production of islet cells for the treatment of diabetes. Such cells will be transplanted into primates initially, but the researchers say that human trials could start in around four years’ time.

In addition to hyperacute rejection by the human immune system, other hurdles facing xenotransplantation include delayed rejection, coagulopathy and chronic T-cell-mediated rejection. Therefore, it may be necessary to add up to three more genes to the DNA of the knock-out pigs, the scientists report.Dr Alan Colman, director of research at PPL Therapeutics, said, “With one of the major technical hurdles and scientific risks overcome, the promise of xenotransplantation is now a reality, with the potential to revolutionise the transplant industry.”

Dr Philip Dyer, President Elect of the British Transplantation Society, said, “Alpha galactosyl knockout pigs have been made before, what's new is that [PPL have] cloned them, which makes [production] easier.” He said, “Of concern is the potential risk of transmission of porcine viruses,” but added, “We would welcome any breakthrough that supports the safe and effective transplantation of animal organs to humans because of the great shortage of hum
'"/>




Page: 1 2

Related medicine news :

1. Innovative device aids in advanced heart failure
2. Innovative footwear may prevent fall in elderly
3. Innovative solution to help reduce the waiting times for kidney transplants
4. Personalized Medicine and Innovative Pharmaceuticals
5. Creation of Cytomegalovirus Vaccine by an Innovative Method
6. Innovative Method for Creating a Human Cytomegalovirus Vaccine Outlined
7. Innovative treatment for Dementia
8. Innovative treatment for Skin Cancer
9. Innovative Movies Show Real-Time Immune-Cell Activity within Tumors
10. Research In A New Direction To Develop Innovative Psychotropic Drugs
11. Autism Expert Creates Innovative Intervention Program
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Xenotransplantation

(Date:11/26/2014)... November 26, 2014 Healthpointe is proud ... Perris , and it will be led by ... in the field of Occupational Medicine and utilizes the ... Medicine specialist delivers quality care for employers and their ... health. , As an Occupational Medicine ...
(Date:11/26/2014)... Recently, Locks-Magnetic.com, a Chinese outstanding Maglocks supplier, is ... on the Internet. It also provides a big discount ... As a leading company in the electronic lock industry, ... buy high quality locks. It can meet the demands ... are not only useful but also affordable. However, inexpensive ...
(Date:11/26/2014)... iFitDress.com, a well-known wedding dress manufacturer and ... 16 cocktail dresses . Included in the new range ... all of these charming outfits are offered at deeply ... has promised that all of the sweet 16 cocktail ... worth mentioning that all of them are set according ...
(Date:11/26/2014)... November 26, 2014 Dr. Rod ... Distinguished Teaching Professor in the Department of Plastic ... facial fat compartments, fat grafting, and modern lift-and-fill ... an annual conference held by the American Society ... of this underlying facial structure were explored in ...
(Date:11/26/2014)... When you,re planning your holiday get-away, don,t forget ... -- such as skiing or hiking, a sports ... fail to take altitude into account when visiting ... of developing fatigue and other symptoms related to ... Melissa Tabor, an assistant professor of sports medicine ...
Breaking Medicine News(10 mins):Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 2Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 3Health News:Fresh Products Launched by Famous Company Lock-Magnetic.com 2Health News:iFitDress.com: Trendy Sweet 16 Cocktail Dresses Unveiled 2Health News:Dr. Rod J. Rohrich Discusses Facelifts at ASPS Annual Assembly 2Health News:Dr. Rod J. Rohrich Discusses Facelifts at ASPS Annual Assembly 3Health News:Don't Let High Altitude Ruin Your Holiday Trip 2
... year in Jacksonville,nearly 600 adults experience some form ... to recovery lacked long-term support. Today, Brooks,Rehabilitation celebrated ... Florida created to help people with acquired brain ... The Brain Injury Association of America estimates that ...
... researcher, administrator, and,Chair Emeritus of the University of Louisville,s ... Foundation for,Biomedical Research (FBR) today announced its board of ... chairman of the board. Dr.,Polk succeeds the late Dr. ... years., "I am honored to represent the Foundation ...
... respiratory problems, CDC report says , , WEDNESDAY, Oct. 22 (HealthDay ... has soared 18 percent in the last decade, with an ... the condition, a new federal report says. , In 2007, ... reported to have had a food or digestive allergy in ...
... Oct. 22 Endocare, Inc.,(Nasdaq: ENDO ), an ... invasive technologies for tissue and tumor,ablation, today announced that ... Oppenheimer 19th Annual Healthcare Conference at 1:20,p.m. ET on ... at the,Waldorf Astoria hotel November 3-4 in New York ...
... supplier, DRE adds affordable, professionally refurbished ultrasound machines to its ... ... KY (PRWEB) October 22, 2008 -- DRE Inc. - named ... businesses in Louisville, Ky. — now sells professionally refurbished ...
... allows more efficient use of larger cleanrooms. , ... ... fabricator and installer of cleanrooms and cleanroom equipment announces ... the AireCell line of extrusions. The new extrusion allows greater ...
Cached Medicine News:Health News:Brooks Rehabilitation Opens First Work-Based Brain Injury Rehab Program in Florida 2Health News:The Foundation for Biomedical Research Names Dr. Hiram C. Polk Jr. Chairman of its Board of Governors 2Health News:Food Allergies Up 18% Among U.S. Children 2Health News:Endocare to Present at Oppenheimer 19th Annual Healthcare Conference 2Health News:DRE Medical Equipment Adds Affordable Refurbished Ultrasound Machines to Product Line 2Health News:DRE Medical Equipment Adds Affordable Refurbished Ultrasound Machines to Product Line 3Health News:Gerbig Engineering Introduces 7 " Deep Extrusions for Cleanroom Construction 2
(Date:11/26/2014)... , Nov. 26, 2014  Perrigo Company plc ("Perrigo") ... provider of "Quality Affordable Healthcare Products®," today announced the ... to the sale of 6,809,210 ordinary shares at a ... full exercise of the option to purchase up to ... LLC and Barclays Capital Inc., as representatives of the ...
(Date:11/26/2014)... 26, 2014 Lexicon Pharmaceuticals, Inc. (Nasdaq: ... of previously announced concurrent financing transactions resulting in ... estimated offering expenses, Lexicon anticipates net proceeds of ... consisted of: , a public offering ... a registration statement that has been declared effective ...
(Date:11/26/2014)... , Nov. 26, 2014  Over 100 million ... those suffer from this pain daily. Chronic and acute ... pain management is born to fulfill the need for ... types of pain. On October 28th, a ... Cumberland, Maryland community.  This new ...
Breaking Medicine Technology:Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3New Pain Management Center Opens in Cumberland, Md. 2
... WASHINGTON, May 28 Leading international experts on ... ones and advocates to share the latest in ... Research Foundation,s,International Symposium on Malignant Mesothelioma, 2008, Thursday, ... Regency on Capitol Hill, in Washington,D.C., The ...
... Demonstrates Sustained and Significant Reductions in Cancer ... ... 28 ACCESS PHARMACEUTICALS, INC.,(OTC Bulletin Board: ACCP) announced today ... anticancer compound, ProLindac(TM) at the,International Symposium on Polymer Therapeutics: Laboratory ...
Cached Medicine Technology:International Symposium on Malignant Mesothelioma 2008 2Access Pharmaceuticals Presents Favorable Ovarian Cancer Data and Clinical Update on ProLindac(TM) Development at Prestigious International Symposium 2Access Pharmaceuticals Presents Favorable Ovarian Cancer Data and Clinical Update on ProLindac(TM) Development at Prestigious International Symposium 3
This 10 L tip was designed for the Pipetman P-2 and P-10. Its MicroPoint design and 2 L reference mark make it ideal for low volume pipetting....
1000 L, Bulk Recommended for 500 and 1000 L pipettes....
... been designed to optimize the accuracy and ... tip products is widely recognized by customers ... been extended over the years and now ... special tips including filter tips, certified pure ...
Inquire...
Medicine Products: