Navigation Links
Xenotransplantation “breakthrough”,

The birth of five cloned piglets last week could significantly increase the success rate of pig-to-human organ transplantation, according to creators, PPL Therapeutics. Previous research has indicated that rejection of animal cells and organs by the human immune system is partially due to the presence of the gene alpha 1,3 galactosyl transferase. The gene codes for an enzyme that adds a sugar// to the surface of pig cells, flagging them up as foreign bodies.

A US subsidiary of PPL Therapeutics, who were also responsible for the creation of Dolly the sheep, used gene targeting to knock out a single copy of alpha 1,3 galactosyl transferase. Nuclear transfer was then used to create the five piglets.The first use of the new technology is likely to involve the production of islet cells for the treatment of diabetes. Such cells will be transplanted into primates initially, but the researchers say that human trials could start in around four years’ time.

In addition to hyperacute rejection by the human immune system, other hurdles facing xenotransplantation include delayed rejection, coagulopathy and chronic T-cell-mediated rejection. Therefore, it may be necessary to add up to three more genes to the DNA of the knock-out pigs, the scientists report.Dr Alan Colman, director of research at PPL Therapeutics, said, “With one of the major technical hurdles and scientific risks overcome, the promise of xenotransplantation is now a reality, with the potential to revolutionise the transplant industry.”

Dr Philip Dyer, President Elect of the British Transplantation Society, said, “Alpha galactosyl knockout pigs have been made before, what's new is that [PPL have] cloned them, which makes [production] easier.” He said, “Of concern is the potential risk of transmission of porcine viruses,” but added, “We would welcome any breakthrough that supports the safe and effective transplantation of animal organs to humans because of the great shortage of hum an organs for transplantation.”

'"/>




Related medicine news :

1. Innovative device aids in advanced heart failure
2. Innovative footwear may prevent fall in elderly
3. Innovative solution to help reduce the waiting times for kidney transplants
4. Personalized Medicine and Innovative Pharmaceuticals
5. Creation of Cytomegalovirus Vaccine by an Innovative Method
6. Innovative Method for Creating a Human Cytomegalovirus Vaccine Outlined
7. Innovative treatment for Dementia
8. Innovative treatment for Skin Cancer
9. Innovative Movies Show Real-Time Immune-Cell Activity within Tumors
10. Research In A New Direction To Develop Innovative Psychotropic Drugs
11. Autism Expert Creates Innovative Intervention Program
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... for human induced pluripotent stem (iPS) cells and other difficult to transfect cells, ... Cloning Medium. The PluriQ™ G9™ Gene Editing System is a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: