Navigation Links
Xenotransplantation “breakthrough”,

The birth of five cloned piglets last week could significantly increase the success rate of pig-to-human organ transplantation, according to creators, PPL Therapeutics. Previous research has indicated that rejection of animal cells and organs by the human immune system is partially due to the presence of the gene alpha 1,3 galactosyl transferase. The gene codes for an enzyme that adds a sugar// to the surface of pig cells, flagging them up as foreign bodies.

A US subsidiary of PPL Therapeutics, who were also responsible for the creation of Dolly the sheep, used gene targeting to knock out a single copy of alpha 1,3 galactosyl transferase. Nuclear transfer was then used to create the five piglets.The first use of the new technology is likely to involve the production of islet cells for the treatment of diabetes. Such cells will be transplanted into primates initially, but the researchers say that human trials could start in around four years’ time.

In addition to hyperacute rejection by the human immune system, other hurdles facing xenotransplantation include delayed rejection, coagulopathy and chronic T-cell-mediated rejection. Therefore, it may be necessary to add up to three more genes to the DNA of the knock-out pigs, the scientists report.Dr Alan Colman, director of research at PPL Therapeutics, said, “With one of the major technical hurdles and scientific risks overcome, the promise of xenotransplantation is now a reality, with the potential to revolutionise the transplant industry.”

Dr Philip Dyer, President Elect of the British Transplantation Society, said, “Alpha galactosyl knockout pigs have been made before, what's new is that [PPL have] cloned them, which makes [production] easier.” He said, “Of concern is the potential risk of transmission of porcine viruses,” but added, “We would welcome any breakthrough that supports the safe and effective transplantation of animal organs to humans because of the great shortage of hum an organs for transplantation.”

'"/>




Related medicine news :

1. Innovative device aids in advanced heart failure
2. Innovative footwear may prevent fall in elderly
3. Innovative solution to help reduce the waiting times for kidney transplants
4. Personalized Medicine and Innovative Pharmaceuticals
5. Creation of Cytomegalovirus Vaccine by an Innovative Method
6. Innovative Method for Creating a Human Cytomegalovirus Vaccine Outlined
7. Innovative treatment for Dementia
8. Innovative treatment for Skin Cancer
9. Innovative Movies Show Real-Time Immune-Cell Activity within Tumors
10. Research In A New Direction To Develop Innovative Psychotropic Drugs
11. Autism Expert Creates Innovative Intervention Program
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/16/2018)... (PRWEB) , ... December 15, 2018 , ... Internal Medicine ... by NJ Top Docs as a Top Doc for 2018. Dr. Sinha is board ... With a patient-centered approach, Dr. Sinha provides the best possible care to his patients ...
(Date:12/14/2018)... ... December 14, 2018 , ... The Parenteral Drug Association ... beginning January 1, 2019. In the fall of 2018, PDA’s 10,500 members had an ... have been elected/appointed as Directors to the PDA Board of Directors for three-year terms ...
(Date:12/13/2018)... ... December 13, 2018 , ... Cantata Health, a leading provider ... introduced new enhancements to its NetSolutions™ platform. The new features and partnerships allow ... and screen time. , Enhancements made to EHR and Financial Management modules ...
(Date:12/13/2018)... ... 2018 , ... Shady Grove Fertility (SGF) welcomes ... seeing patients at SGF’s Woodbridge, VA location. Dr. Swelstad will provide ... options for female and male infertility, as well as elective fertility preservation, oncofertility ...
(Date:12/13/2018)... (PRWEB) , ... December 13, 2018 , ... ... Careers at High Schools , As part of its commitment to providing more jobs ... schools , Fellow Health Partners, Inc., a New York based medical business solutions ...
Breaking Medicine News(10 mins):
(Date:12/13/2018)... ... December 13, 2018 , ... Shady Grove Fertility (SGF), a nationally ... 50 states and 35 countries around the world, announced today it’s expanding its program ... practice. Dr. Li will see Mandarin and English-speaking patients in Rockville, MD ...
(Date:12/13/2018)... ... December 13, 2018 , ... ... Annual Meeting April 1 to 4, 2019, at the Hyatt Regency in Chicago. ... speaking as well as 4,200-plus attendees. In attendance will be the top C-suite ...
(Date:12/10/2018)... ... December 10, 2018 , ... Parkstone Growth Partners (“Parkstone”) ... Parkview Dental Partners (“Parkview Dental”), a dentist-founded dental growth and management partnership. Parkview ... a group dental practice comprised of 16 dentists and hygienists across eight offices ...
Breaking Medicine Technology: