Navigation Links
Wound Healing Accelerated By Mutation In Deafness Gene

Dr. Stella Man, from the Institute of Cell and Molecular Sciences, Queen Mary's University, London, UK, says that a mutation in a gene that is linked to deafness// could have a major part to play in wound healing. Dr Man is to present these findings at the annual conference of the European Society of Human Genetics in Amsterdam, The Netherlands today.

This discovery has the potential to be useful in many types of wound healing, including those that are inflicted post-surgically. The team of researchers led by Professor David Kelsell was analyzing the gene (GJB2). A common mutation in this gene is the cause for genetic deafness.

"Since many people carry this mutation", Dr. Man said, "and people who have just one such mutation are not deaf, we felt that there might be some evolutionary advantage to it, so we decided to investigate how the mutation affected the ability of cells to communicate with each other in the epidermis where Cx26 is also expressed."

Cells present in the skin have to have a way of communicating with each other in order to effectively repair and heal wounds. This process involves gap junctions in the skin regulated by proteins called connexins, of which Cx26 is one. "When we looked at the function of Cx26 in a laboratory skin model", said Dr. Man, "we found that it was directly associated with wound healing and bacterial invasion. We concluded that there is a definite advantage to carrying a mutation in this protein."

She added that a drug that can block Cx26 protein in the wound could potentially accelerate healing. "It is interesting to speculate that Cx26 deafness mutations have been selected over the evolutionary process due to their beneficial effects on wound healing."

Contact: Mary Rice

European Society of Human Genetics

Source: Eurekalert


Page: 1

Related medicine news :

1. Wound healing made faster
2. Psychological Stress Delays Wound Healing
3. Wound healing affected by Psychological stress
4. Predictors Of Wound Infection In Ventral Hernia Repair
5. Wound Healing Found To Be Slower In Couples Who Fight Often
6. ‘Marriage Squabbles’ bad for both Emotional and Physical Wound
7. Wounds Heal 25% Faster In Older Adults Who Exercise Regularly
8. Honey Works Faster than Antibiotics in Healing Wounds
9. Heroin Injection may Lead to Wound Botulism
10. Nurses Ease the Wounded Heart
11. Guidelines for Chronic Wounds Care
Post Your Comments:

(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
Breaking Medicine Technology: