Navigation Links
World’s First Attempt To Restore Sight Using Gene Therap

Officials have announced the completion of the world’s first eye operation using gene therapy. //A team of British doctors from Moorfields Eye Hospital and University College London (UCL) carried out the operations in an attempt to cure a serious sight disorder- Leber's Congenital Amaurosis or LCA.

The group operated on 12 young adults with LCA, a type of inherited childhood blindness caused by a single abnormal gene.

Leber's Congenital Amaurosis is not a single specific disorder. It is the term used for a group of conditions that have in common, abnormality of retinal receptors, which result in severe vision impairment from birth.

Within the LCA group, genetic testing can now in some cases, identify which of more than six distinct genes has an error, but as yet this does not alter management. However gene therapy, with the goal of at least stabilizing any residual vision, may be a possibility in the not too distant future for the small number of children with the RPE65 genotype.

The condition prevents the retina from detecting light properly, resulting in progressive deterioration and severely impaired eyesight. There is no effective treatment as of now.

The new experimental procedure involved inserting normal copies of the faulty RPE65 gene into cells of the retina -the light-sensitive layer of cells at the back of the eye - using as a vehicle like a harmless virus or vector.

The doctors operated first on Robert Johnson, a UK man born with a sight disorder which means he can see very little at night, and which deteriorates with age. Yet, it will be several months before the researchers know whether their work has been a success.

The British doctors are working alongside Seattle, Washington-based biotech firm Targeted Genetics Corp., which made the vector being used in the Phase I/II trial.

This move into human testing follows 15 years of laboratory and animal experimentation, incl uding tests on dogs with LCA, whose vision was restored to the extent they could navigate a maze with ease.

Said Robin Ali, professor of human molecular genetics at UCL: "Testing it for the first time in patients is very important and exciting and represents a huge step towards establishing gene therapy for the treatment of many different eye conditions."

The clinical trial was given a million pounds ($2 million) of funding by Britain's Department of Health, which said the pioneering research underlined the country's leading position in gene therapy in Europe. The idea of using gene therapy to fix diseases caused by genetic faults has long appealed to scientists, although getting the idea to work in practice has proved the tricky part.

Some gene therapy approaches have helped patients. But one 18-year-old volunteer died in a gene therapy experiment in 1999 and two French boys cured of rare immune disease later developed leukemia. Over 70 percent of gene therapy trials to date have been for cancer, where the process is complicated by the need to reach multiple sites in the body.

In contrast, the eye is relatively straightforward according to Andrew George of London's Imperial College. "The eye is good for gene therapy because it is a simple organ and it is easy to see what is going on. There is hope that once gene therapy is developed in the eye, scientists could move on to more complex organs," he was quoted.

Some indications of the result may be available within several months. However, the subjects - Mr. Johnson and the 11 others - will need to be followed up to assess the long term effect of the treatment. It is anticipated that the best results will be achieved in younger patients, as they will be treated when the disease is in its earlier stages of development.
ANN/V
'"/>




Related medicine news :

1. Discovery of World’s smallest laser
2. SNUPPY – Woo Suk Hwang reveals World’s first dog cloe
3. World’s First Nerve Stem Cells Produced
4. India Can Manage World’s Healthcare Crisis By 202
5. World’s Oldest Mothe
6. World’s First Triple Transplant Performed by Australian Surgeon
7. World’s First Pediatric Laparoscopic Liver Surger
8. Trans-fat Foods to Vacate Room from the World’s Leading Hotelier
9. Chinese Doctors Perform World’s First Disc Transplant
10. Thailand Claims World’s First Successful Heart Separation in Siamese Twin
11. World’s First ‘green’ Skyscraper to Be Built in Duai
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
Breaking Medicine Technology: