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Women With Atypia Nearly Eight Times More Likely to Develop Breast Cancer

ed to the general population; this risk more than doubled when two sites were found and augmented to nearly eightfold as sites increased to three or more.

The group of women with the highest risk had three or more areas of atypia and calcification -- with a 10.4-fold risk over the general population.

With the ability to stratify the risk of breast cancer in women with atypia, we can have more informed discussions with our patients regarding their personal risk. This will help us to have individualized discussions regarding how aggressively to pursue risk-reduction treatments, says Dr. Degnim.

These findings resulted from reassessing the records of 331 women with atypia identified within the Mayo group of 9,376 women who had benign breast biopsies surgically obtained between 1967 and 1991.

More than half (55.9 percent) of the women were over age 55 when diagnosed with atypia, and 42.9 percent had a family history of breast cancer. The majority (68.6 percent) of women showed calcification in the biopsy tissue, and 40 percent had multiple sites of atypical hyperplasia.

The current study contributes to Mayos up-and-coming model that seeks to identify every womans risk more accurately and to tailor screening and risk-reduction measures to women depending on their individual risks.


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