( The Research study found that younger m...)Women Taking Oestrogen Therapy Showed Reduced Coronary Artery Calcification,Health

The Research study found that younger menopausal women (aged 50-59) who received a standard dose of oral conjugated estrogens had significantly less coronary artery calcification at the end of the study period compared with those taking placebo. Coronary artery calcification is a marker of plaque in the arteries and a predictor of future cardiovascular events.

In the five years since the WHI study ended, new data have emerged that help put the initial findings into perspective. These results showed that in these younger menopausal women, estrogen therapy reduced calcified plaque buildup in the arteries, says Howard Hodis, M.D., Professor of Medicine and Preventive Medicine; Director, Artherosclerosis Research Unit, University of Southern California.

These data support initiation of estrogen therapy, where indicated when a woman first enters menopause and begins experiencing symptoms and bone loss.

Wyeth is unaware of any coronary artery calcification data for women taking estrogen plus progestin. The investigators did not study coronary artery calcification in women who were over 60 at the beginning of the study.

This study found no apparent increase in coronary heart disease for women who initiated hormone therapy within 10 years of menopause; and a statistically significant reduction in total mortality among women aged 50-59 in the group receiving hormone therapy compared with those in the placebo group.

The recent pooled analysis published in JAMA provides reassurance about coronary artery disease to newly menopausal women considering estrogen plus progestin therapy or estrogen alone therapy for symptom relief and prevention of postmenopausal bone loss.

The recent pooled analysis published in JAMA provides reassurance about coronary artery disease to newly menopausal women considering estrogen plus progestin therapy or estrogen alone therapy for symptom relief and prevention of postmenopausal bone
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