Navigation Links
Womb may have impact upon Blood Pressure

New research totals to a growing body of evidence that adult health is set to a considerable degree by conditions in the womb and proposes that programming may start earlier in pregnancy than previously believed. According to the study it was found that fetuses with shorter thigh bones// at 24weeks had higher blood pressure at the age of 5 than those with longer thigh bones.

Understanding how life in the womb influences later health has become a hot area of medical research. It has focused mostly on the effect of birth weight on health and the subsequent development of illnesses such as heart disease, high blood pressure, diabetes and osteoporosis. But the latest study is among the first to find evidence earlier in human life.

Scientists believe that when a fetus is undernourished, it diverts resources to areas it really needs at the time, such as the brain, at the expense of organs it will need later in life. That may permanently change the baby's structure, functioning and metabolism, experts believe.

According to Dr. David Barker, an epidemiologist, who pioneered fetal programming research, felt that there's a lot of work about the size at birth. Birth weight is a crude measurement. It tells you very little because babies can reach the same birth weight by many different paths of growth.

Barker at the University in England said that because of technology advances, people are able to study children who have had serial measurements of size in (the uterus) that follow their growth, and these observations take us back into early pregnancy.

The study, led by Dr. Kevin Blake at the University of Western Australia, involved ultrasounds done at 18, 24, 28, 34 and 38 weeks of pregnancy on 650 women with normal pregnancies. During each scan, doctors measured the circumference of the head and abdomen and the length of the babies' thigh bones.

Blood pressure was measured in about 250 of the resulting children at age 6. The researchers found that for every one-tenth of an inch deviation from the typical thigh bone length at key stages in the womb, systolic blood pressure - the higher of the two numbers - was changed by about 2 points. Shorter thighs meant higher blood pressure.

That effect was first seen at 24 weeks of pregnancy. Neither head nor abdomen circumference was linked to later blood pressure. ``We don't know whether a very small change in blood pressure at age 6 has any value in predictability of disease, but it's still a move forward in understanding what kind of factors we can look at before birth and use as predictors for potential signs of disease,'' said Kent Thornburg, a fetal physiologist and director of the Heart Research Center at Oregon Health Sciences University who was unconnected with the research.

The thigh bone is easy to measure and skeletal growth is a good measure of the rate a fetus is growing, said Mark Hanson, director of the Center for the Fetal Origins of Adult Disease at England's Southampton University.

``Skeletal growth is not just determined by how tall the parents are. There's a complex interaction between the fetal genetic drive to grow - inherited from the parents - and the environment in the womb in early gestation,'' said Hanson, a fetal physiologist who was not involved in the study.

``This study is focusing our attention on early gestation. It's making it clear that it really is fetal growth we're talking about here, not just some funny thing linked to birth weight itself. And it's pointing a finger very clearly that in the fetal growth process there's an interaction between the (genes) and the environment,'' he said. Rat studies have previously indicated the womb environment, influenced by the mother's nutrition, is important for later disease.

One study showed that pregnant rats given a low-protein diet for the first four days of pregnancy - before the embryo even implant s in the womb and before the placenta is formed - produced offspring with high blood pressure.

The risk of disease in adulthood builds up over a lifetime and experts don't know to what degree fetal programming influences the eventual likelihood of disease, but they believe it is considerable. ``The sort of calculations that have been done would suggest that it's certainly a bigger effect than smoking. It's certainly an effect at least of the magnitude of obesity and lack of exercise,'' Hanson said.


Related medicine news :

1. Double impact vaccine
2. Sex timing has no impact on risk of Birth defects
3. SARS impact could be devastating
4. Marriage does not have much impact on life satisfaction
5. Breastfeeding not found to have an impact on weight of the child.
6. Burning energy and its impact on health during exercise can be of genetic origin
7. Eating together has both psychological and health impacts
8. Even 6 months or more of hormone therapy treatment does not impact longevity of prostate cancer patients
9. Recommendations for Treatment of Blood Pressue
10. Blood Cells Capable of Regenerating Liver
11. Blood clots likely in long travel
Post Your Comments:

(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
Breaking Medicine Technology: