A Johns Hopkins study has proven false established medical practice that an antiretroviral drug widely used to treat hepatitis B liver infections was safe to use// on its own in patients co-infected with HIV. Their findings demonstrate that treatment with entecavir leads to cross-resistance to other antiviral drugs used to treat the AIDS virus.
“Our results show that entecavir is no different from any other that has been shown to be active against HIV - it breeds resistance rapidly, despite its ability to reduce the amount of HIV in the body,” says senior study author and infectious disease specialist Chloe Thio, M.D.
Researchers say the findings, to be presented Feb. 28 at the 2007 Conference on Retroviruses and Opportunistic Infections (CROI) in Los Angeles, have serious implications for the more than 4 million people worldwide believed to be infected with both viral illnesses but who need to treat their hepatitis B and are not yet on anti-HIV drugs.
Authors of the study have informed the U.S. Food and Drug Administration of their results so that prescribing physicians can be notified and so that drug labeling can be changed. They have also notified Bristol-Myers Squibb, which makes and sells entecavir under the brand name Baraclude.
“The alert should go out to co-infected people to consult with their physicians immediately about entecavir to see if it is the right drug to treat their hepatitis B in the first place and to evaluate alternative therapies,” says Thio, an associate professor of medicine at The Johns Hopkins University School of Medicine.
Thio says she has stopped prescribing entecavir as her first option in treating hepatitis B in co-infected patients who are not already using drugs to suppress HIV.
“The good news is that co-infected patients already on HIV therapy can still use entecavir to treat their hepatitis B, but the bad news is that there are now fewer options for treatPage: 1 2 3 Related medicine news :1
. Prescription Drug Use Varies Widely Between States2
. Benefits Of The Worlds Most Widely Used Beverage3
. Differentiated Thyroid Carcinoma Can Widely Infiltrate The Larynx 4
. Breast Cancer Drug Should Be Made Widely Available5
. Widely Prescribed Diabetes Drug Falls Short of Promise, Says New Review6
. Merck Announces Plans for Licensing Atripla Widely in Developing World7
. Vitamin B for Hepatitis8
. Hepatitis G May Boost HIV Survival9
. Cure for Hepatitis B10
. Hepatitis E virus made impotent11
. Sharing injection equipment spreads Hepatitis C