Navigation Links
Why Malaria Parasite Affects Red Blood Cells Deformability Revealed

A study led by researchers at the Massachusetts Institute of Technology (MIT) has found out why red blood cells start to lose their ability to deform, and squeeze through tiny blood vessels during the first 24 hours of invasion by the malaria-inducing parasite Plasmodium falciparum.

The researchers knocked out the gene for a parasite protein called RESA (ring-infected erythrocyte surface antigen), and found that the protein, transferred from the parasite to the cell's interior molecular network, had caused red blood cells to become less deformable.

"This is the first time a particular protein has been shown to have such a large effect on red blood cell deformability," said Subra Suresh, Ford Professor of Engineering and senior author of the study.

According to the researchers, their findings may lead to the development of treatments that target the parasite protein.

The RESA protein has long been suspected to be involved in the early stages of that process. The parasite produces RESA during the first stage of malaria, and then transports it to the cell surface.

During the study, the researchers cloned the parasite, knocked out the gene that produces RESA, and then measured the red blood cells' deformability with "optical tweezers" that use lasers to stretch cell membranes.

The deformability remained normal in red blood cells infected by parasites without RESA during the first 24 hours of infection, while in parasites where RESA was turned back on after being knocked out, it was affected in a manner as though the protein was never knocked out.

"That the deformability changed several-fold was a big surprise," said Suresh.

Published online in the Proceedings of the National Academy of Sciences, the study also found that RESA has a much greater impact on the deformability of red blood cells at high fever temperatures than in normal body temperature.

The researchers belie ve that when RESA travels to the cell membrane, it binds to the cell's cytoskeleton--a scaffolding of proteins that lies just inside the cell membrane.

In future studies, the researchers plan to study the effects of proteins produced by the malaria parasite during later stages of infection. They also plan to look at whether the RESA protein plays any role in why another strain of the malaria parasite, Plasmodium vivax, is less lethal than P. falciparum.


'"/>




Related medicine news :

1. Malaria strikes Munger tribals
2. Sponging Cattle betters spraying in eradicating Malaria
3. Gene researchers make Malaria-resistant mosquito
4. More Treatment Options For Malaria
5. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
6. Jharkhand reports 13,000 Malaria cases
7. Researchers Discover Protein That Causes Malaria
8. Malarial gene ascertained
9. Artesunate Is Better For Malaria Than Quinine
10. New Strategies For Effective Treatment Of Malaria
11. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/22/2017)... New Freedom, PA (PRWEB) , ... April 22, ... ... of healthcare experience to his role as Vice President of Sales and Business ... direction of key GPO/IDN business partner engagements, business development, and strategic planning for ...
(Date:4/21/2017)... ... April 21, 2017 , ... Contrary to ... youth violence is declining—and at noteworthy rates. Between 2002 and 2014, Salas-Wright and ... involved in violence in the United States. The study, Trends in Fighting ...
(Date:4/21/2017)... , ... April 21, 2017 , ... Dudnyk has announced ... emphasizes the agency’s conviction that the full potential of specialty and orphan brands can ... appreciated and aligned. , “The Unifying Effect is at the heart of a ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... performance system, has partnered with O2X , an active lifestyle company that ... on improving the health of firefighters, police offers, first responders, military officers and ...
(Date:4/21/2017)... ... 21, 2017 , ... Metrasens is honoured to have won ... most prestigious award for business success. The company has been recognized for ... grown by a total of 400% over the last six years. , Metrasens ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 2017 Research and Markets has announced ... Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive ... offering. ... market was valued at US$ 7,167.6 Mn in 2015, and ... at a CAGR of 5.6% from 2016 to 2024. ...
(Date:4/19/2017)... April 19, 2017 Cardiology devices segment is anticipated ... The Cardiology Devices segment is likely to create ... Mn in 2018 over 2017. By the end of 2027, ... close to US$ 700 Mn, expanding at a CAGR of ... the Asia Pacific reprocessed medical devices ...
(Date:4/19/2017)... NASHVILLE , Tenn. and DALLAS , ... and EndoStim, Inc., announced that the first patients in ... with the EndoStim device in the Lower Esophageal Sphincter ... is a minimally-invasive implantable device designed to provide long-term ... through neurostimulation. GERD affects nearly 65 million ...
Breaking Medicine Technology: