Navigation Links
Why Malaria Parasite Affects Red Blood Cells Deformability Revealed

A study led by researchers at the Massachusetts Institute of Technology (MIT) has found out why red blood cells start to lose their ability to deform, and squeeze through tiny blood vessels during the first 24 hours of invasion by the malaria-inducing parasite Plasmodium falciparum.

The researchers knocked out the gene for a parasite protein called RESA (ring-infected erythrocyte surface antigen), and found that the protein, transferred from the parasite to the cell's interior molecular network, had caused red blood cells to become less deformable.

"This is the first time a particular protein has been shown to have such a large effect on red blood cell deformability," said Subra Suresh, Ford Professor of Engineering and senior author of the study.

According to the researchers, their findings may lead to the development of treatments that target the parasite protein.

The RESA protein has long been suspected to be involved in the early stages of that process. The parasite produces RESA during the first stage of malaria, and then transports it to the cell surface.

During the study, the researchers cloned the parasite, knocked out the gene that produces RESA, and then measured the red blood cells' deformability with "optical tweezers" that use lasers to stretch cell membranes.

The deformability remained normal in red blood cells infected by parasites without RESA during the first 24 hours of infection, while in parasites where RESA was turned back on after being knocked out, it was affected in a manner as though the protein was never knocked out.

"That the deformability changed several-fold was a big surprise," said Suresh.

Published online in the Proceedings of the National Academy of Sciences, the study also found that RESA has a much greater impact on the deformability of red blood cells at high fever temperatures than in normal body temperature.

The researchers belie
'"/>




Page: 1 2

Related medicine news :

1. Malaria strikes Munger tribals
2. Sponging Cattle betters spraying in eradicating Malaria
3. Gene researchers make Malaria-resistant mosquito
4. More Treatment Options For Malaria
5. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
6. Jharkhand reports 13,000 Malaria cases
7. Researchers Discover Protein That Causes Malaria
8. Malarial gene ascertained
9. Artesunate Is Better For Malaria Than Quinine
10. New Strategies For Effective Treatment Of Malaria
11. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
Post Your Comments:
(Date:3/27/2015)... Florida Hospital is excited to continue its ... health care provider for the 2015 and 2016 season. As ... care and an athletic trainer for the team throughout each ... season against the Cleveland Gladiators at Amalie Arena; the game ... important to us as it gives us the opportunity, to ...
(Date:3/27/2015)... 27, 2015 First Choice Emergency Room ... new facility is located 12665 W Lake Houston Pkwy, Houston, ... of Summerwood, I look forward to delivering the highest quality ... Facility Medical Director of First Choice Emergency Room Summerwood. ... made a donation to Summer Creek High School at First ...
(Date:3/27/2015)... NY (PRWEB) March 27, 2015 Top ... plastic surgery patients travel to the Dominican Republic to ... plastic surgery clinic is turning the medical tourism industry ... surgery patients — with trustworthy services becoming the central ... selecting a plastic surgeon. Patients are not only attracted ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 On ... EcoLuxe Lounge in the Stardust Penthouse on the ... Durkin, Los Angeles’ leading sustainable product TV and ... this unforgettable day-long event, which featured some of ... ecologically sound products and services. , “We were ...
(Date:3/27/2015)... 27, 2015 The report “CountryFocus ... an essential source of information on and analysis ... Germany. Germany’s increasingly elderly population and its associated ... market. In 2013, the elderly accounted for 27.1% ... Compound Annual Growth Rate (CAGR) of 1.2% to ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3Health News:Choices Recovery Releases 'Salute to the Oscars' EcoLuxe Lounge Compilation Video 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4
... 1,000 Reported Incidents, Caregivers Call for Comprehensive Process to Verify Signatures ... 31 Home care workers called for a hand-examination of each ... union, saying they had been subjected to lies, coercion, and fraud. ... the Service Employees International Union, United Healthcare Workers - West (SEIU-UHW), ...
... ... ... -- TDI, a leading provider of agent productivity solutions for contact centers, announced today that ... healthcare systems provider to the Greater New Orleans area. , , , , ,As an ...
... , , , ... HSP ), the world leader in generic injectable pharmaceuticals, today announced ... company,s applications for six new presentations of therapeutic heparin in single- ... to prevent clot formation in central venous catheters and for anticoagulant ...
... , , , CHADDS FORD, Pa., Aug. ... will present at the Thomas Weisel Partners Healthcare Conference 2009 on Thursday, Sept. ... Endo, will review the company,s products and development programs. , , ... website at www.endo.com under the investors section. ...
... , BERWYN, Pa., Aug. 31 Encorium ... clinical research organization (CRO) conducting studies in over 30 countries for ... that on August 25, 2009, it received a letter from The ... 10-Q for the period ended June 30, 2009, NASDAQ has determined ...
... , , , ... (the "Company") today announced that, at the Company,s 2009 Annual Meeting ... re-elect by an overwhelming majority all of the Company,s nominees to ... meeting were 63,725,589, representing approximately 56% of the 114,007,240 shares outstanding ...
Cached Medicine News:Health News:San Francisco Home Care Workers Describe Lies, Coercion, and Fraud in Union Signature Drive 2Health News:San Francisco Home Care Workers Describe Lies, Coercion, and Fraud in Union Signature Drive 3Health News:TDI Announces New Reseller Agreement With Executone 2Health News:Hospira Receives FDA Approval for Six New Presentations of Heparin 2Health News:Endo Pharmaceuticals to Present at Thomas Weisel Partners Healthcare Conference 2009 2Health News:Encorium Receives NASDAQ Deficiency Letter Regarding Stockholders' Equity 2Health News:Encorium Receives NASDAQ Deficiency Letter Regarding Stockholders' Equity 3Health News:Healthcare Trust of America, Inc. Announces Results of 2009 Annual Meeting of Stockholders 2Health News:Healthcare Trust of America, Inc. Announces Results of 2009 Annual Meeting of Stockholders 3
(Date:3/27/2015)... , March 27, 2015 ... 2015" therapeutic market research report of 52 pages ... online business intelligence library. The report ... on the therapeutic development for Visceral Pain, complete ... by drug target, mechanism of action (MoA), route ...
(Date:3/26/2015)... HOUSTON , March 26, 2015  The ... of a study independently conducted by the Department ... Japan have been published. ... compared 5-fluorouracil hepatic arterial infusion as post-operative adjuvant ... colorectal metastasis of the liver. ...
(Date:3/26/2015)... March 26, 2015  OncoGenex Pharmaceuticals, Inc. (NASDAQ: ... clinical developments and announced fourth quarter and year ... Developments and Anticipated Near-term MilestonesCustirsen , ... to negotiate the termination of their collaboration and ... final termination agreement are ongoing. , Two ...
Breaking Medicine Technology:Visceral Pain Pipeline Review H1 2015 Market Research Report 2Visceral Pain Pipeline Review H1 2015 Market Research Report 3Visceral Pain Pipeline Review H1 2015 Market Research Report 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 2OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 3OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 5OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 6OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 7OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 8
...  Scientists at The Scripps Research Institute have shown that an ... of cocaine. The findings could lead to human clinical trials ... in case of emergency. Cocaine is involved in more than ... in the United States. The findings, reported recently ...
... FRANCISCO, April 18, 2012 Although adherence to hypertension ... total costs of care are higher for adherent patients ... a new study from pharmacy benefit manager Prime Therapeutics ... Academy of Managed Care Pharmacy (AMCP),s 24th Annual Meeting ...
Cached Medicine Technology:Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose 2Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose 3Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose 4Hypertension Drug Adherence Associated with Fewer Hospitalizations and Lower Medical Costs but Increased Total Care Costs 2
... provides a convenient reservoir of cooling water for the ... extended period of time or in a location which ... the hot side of the thermoelectric heat pump. ... is adequate to run the 900R for up to ...
Punch set for Advanced Tissue Arrayer, 2.0 mm...
Inquire...
Inquire...
Medicine Products: