Navigation Links
Why Malaria Parasite Affects Red Blood Cells Deformability Revealed

A study led by researchers at the Massachusetts Institute of Technology (MIT) has found out why red blood cells start to lose their ability to deform, and squeeze through tiny blood vessels during the first 24 hours of invasion by the malaria-inducing parasite Plasmodium falciparum.

The researchers knocked out the gene for a parasite protein called RESA (ring-infected erythrocyte surface antigen), and found that the protein, transferred from the parasite to the cell's interior molecular network, had caused red blood cells to become less deformable.

"This is the first time a particular protein has been shown to have such a large effect on red blood cell deformability," said Subra Suresh, Ford Professor of Engineering and senior author of the study.

According to the researchers, their findings may lead to the development of treatments that target the parasite protein.

The RESA protein has long been suspected to be involved in the early stages of that process. The parasite produces RESA during the first stage of malaria, and then transports it to the cell surface.

During the study, the researchers cloned the parasite, knocked out the gene that produces RESA, and then measured the red blood cells' deformability with "optical tweezers" that use lasers to stretch cell membranes.

The deformability remained normal in red blood cells infected by parasites without RESA during the first 24 hours of infection, while in parasites where RESA was turned back on after being knocked out, it was affected in a manner as though the protein was never knocked out.

"That the deformability changed several-fold was a big surprise," said Suresh.

Published online in the Proceedings of the National Academy of Sciences, the study also found that RESA has a much greater impact on the deformability of red blood cells at high fever temperatures than in normal body temperature.

The researchers belie ve that when RESA travels to the cell membrane, it binds to the cell's cytoskeleton--a scaffolding of proteins that lies just inside the cell membrane.

In future studies, the researchers plan to study the effects of proteins produced by the malaria parasite during later stages of infection. They also plan to look at whether the RESA protein plays any role in why another strain of the malaria parasite, Plasmodium vivax, is less lethal than P. falciparum.


'"/>




Related medicine news :

1. Malaria strikes Munger tribals
2. Sponging Cattle betters spraying in eradicating Malaria
3. Gene researchers make Malaria-resistant mosquito
4. More Treatment Options For Malaria
5. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
6. Jharkhand reports 13,000 Malaria cases
7. Researchers Discover Protein That Causes Malaria
8. Malarial gene ascertained
9. Artesunate Is Better For Malaria Than Quinine
10. New Strategies For Effective Treatment Of Malaria
11. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... , ... May 26, 2017 , ... ... announce a new educational seminar to focus on current legislative activity and the ... will begin at 1 p.m. Sunday, Sept. 10, and will continue through Monday, ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device Interface (SDI). Somnoware ... for diagnostic device operations. With this platform, initializing devices and importing studies are ...
(Date:5/26/2017)... ... 26, 2017 , ... Boar’s Head Brand®, one of the ... Day entertaining that are sure to satisfy your guests’ flavor cravings, while adding ... cheeses featured in these refreshingly balanced recipes are packed with flavor, creating the ...
(Date:5/26/2017)... ... May 26, 2017 , ... On May 24, the Congressional Budget Office ... U.S. House on May 4, would result in 23 million Americans losing their health ... the 2010 Patient Protection and Affordable Care Act (ACA). , “It is clear ...
(Date:5/26/2017)... ... May 26, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... focusing on the Peace Agreements being discussed by President Donald Trump and the rest ... to try to speed up peace talks in the continuous battle between Israel and ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)... Canada joint tech company Laughing Face has developed ... and features a powerful disinfection process. The company has ... and sanitizes women,s panties or babies, cloth diapers in 25 minutes. ... Laughing ... external water inlet. ...
(Date:5/10/2017)... 10, 2017 Radiology has become the number ... have also spiraled to the number one ranking as ... than ever before as the most complete and reliable ... with lower back pain an MRI may confirm a ... pain, resulting in entirely different treatment protocols.  In these ...
(Date:5/9/2017)... PORTLAND, Ore. , May 9, 2017 /PRNewswire/ ... company that provides technology solutions to improve the ... reported financial results for the first quarter ended ... that our products enable our customers to identify ... them to intervene before events like heart attacks ...
Breaking Medicine Technology: