Navigation Links
Whole-body hypothermia reduces risk of death in Encephalopathy in infants

Among infants, hypoxic–ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood//.

Infants with moderate encephalopathy have a 10% risk of death, and those who survive have a 30% risk of disabilities. 60% of infants with severe encephalopathy die, and many, if not all, survivors are handicapped. Treatment is currently limited to supportive intensive care. Hypothermia has previously been found to be protective against brain injury after asphyxiation in animal models.

With a background study on the feasibility of whole-body cooling in a pilot study of neonates with encephalopathy, Dr. Shankaran from Wayne State University and colleagues conducted a randomized, controlled trial to evaluate whether whole-body cooling initiated before 6 hours of age and continued for 72 hours in term infants with encephalopathy would reduce death or disability at 18 to 22 months of age as compared with infants given usual care. The study, funded by the National Institute of Child Health and Human Development (NICHD) and conducted by investigators with the Neonatal Research Network, was published in October 13 issue of the New England Journal of Medicine.

A total of 239 babies with a gestational age of 36 weeks or more were enrolled in the study, and 102 were assigned to hypothermia. Infants were randomized within 6 hours of birth and all had either severe acidosis, or perinatal complications and resuscitation at birth. All had moderate to severe encephalopathy.

During the study, infants were randomly assigned to usual care (control group) or whole-body cooling to an esophageal temperature of 33.5°C for 72 hours, followed by slow re-warming (hypothermia group). Neurodevelopmental outcome was assessed at 18 to 22 months of age. The primary outcome was a combined end point of death or moderate or severe disability.

Infants assigned to the hypothermia group were initially placed on an infant-sized cooling blanket that was pre-cooled to 5° C. An esophageal probe was placed and the infant was covered with a second cooling blanket. Esophageal and skin temperatures were monitored every 15 min for four hours, then every hour for next eight hours, and finally every four hours for the remainder of the cooling period. Infants in the control group were cared for with overhead radiant warmers and had skin temperature maintained between 36.5° C and 37.0° C.

After the study, 44% percent of infants randomized to hypothermia died or had disability compared with 62% of infants in the control group. Twenty-four infants died in the hypothermia group, compared with 38 among the controls, but this was not significant. There was no increase in major disability among survivors; the rate of cerebral palsy was 19% in the hypothermia group as compared with 30% in the control group.

The authors conclude that whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic–ischemic encephalopathy. These findings demonstrate the safety and effectiveness of whole-body cooling in reducing the risk of death or disability among infants with moderate or severe encephalopaty.
'"/>




Related medicine news :

1. Stress reduces your immunity- startling but true!!!!!
2. Thirty minutes of work up per day reduces the risk of Diabetes
3. Aspirin reduces deaths
4. Tomato Sauce reduces Cancer Risk- Study
5. Calcium reduces colon cancer risk
6. New pacemaker reduces risk of heart failure
7. Vitamin D reduces heart risk
8. Back exercises reduces Osteoporosis
9. Caffeine reduces infant blood flow
10. Radiation reduces cancer recurrence
11. Tamoxifen reduces breast cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... ... February 10, 2016 , ... Gout is like no other ... that is often severe, with intense swelling and redness. It is triggered by the ... but older adults are the most susceptible, according to the February 2016 issue of ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... four time Emmy award winner and inspirational speaker Jan Fox will serve as ... by Speaking Boldly will provide participants with tools to more effectively communicate with ...
(Date:2/10/2016)... MN (PRWEB) , ... February 10, 2016 , ... ... that it will attend the Ohio Safety Congress and Expo event March 9-11, ... at the Greater Columbus Convention Center. , As the longest running and ...
(Date:2/10/2016)... ... February 10, 2016 , ... IDEX Health & Science, ... stainless steel (PLS) columns combine the strength of traditional stainless steel with the ... biological samples while operating at ultra-high pressures of 20,000 psi. The higher operating ...
(Date:2/10/2016)... ... February 10, 2016 , ... Workrite Ergonomics, who is ... has evolved from humble beginnings to being an internationally recognized leader in their industry. ... are today”, said Charlie Lawrence, President of Workrite. “Workrite recognized the importance of ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... February 10, 2016 --> ... research report "Pharmaceutical Packaging Equipment Market by Package Type ... Serialization), by Product Type (Tablet, Powder, Cream, Syrup, Aseptic ... MarketsandMarkets, studies the global market during the forecast period of ... at a CAGR of 6.9% during the forecast period ...
(Date:2/10/2016)... 2016 On Tuesday, February 9th, the ... with its Arthritis Advisory Committee to discuss ... & Johnson,s Remicade and most likely the ... U.S. The Biologics Prescribers Collaborative (BPC) along ... for Patient Access, American Association of Clinical ...
(Date:2/10/2016)... 10, 2016 --> ... Therapeutics and Companion Diagnostic Market to 2019 - ... Environment" research report indicates that the core personalized ... by 2020 growing at a CAGR of 8.74%. ... and targeted therapeutics and is dominated by oncology, ...
Breaking Medicine Technology: