Navigation Links
Whole-body hypothermia reduces risk of death in Encephalopathy in infants

Among infants, hypoxic–ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood//.

Infants with moderate encephalopathy have a 10% risk of death, and those who survive have a 30% risk of disabilities. 60% of infants with severe encephalopathy die, and many, if not all, survivors are handicapped. Treatment is currently limited to supportive intensive care. Hypothermia has previously been found to be protective against brain injury after asphyxiation in animal models.

With a background study on the feasibility of whole-body cooling in a pilot study of neonates with encephalopathy, Dr. Shankaran from Wayne State University and colleagues conducted a randomized, controlled trial to evaluate whether whole-body cooling initiated before 6 hours of age and continued for 72 hours in term infants with encephalopathy would reduce death or disability at 18 to 22 months of age as compared with infants given usual care. The study, funded by the National Institute of Child Health and Human Development (NICHD) and conducted by investigators with the Neonatal Research Network, was published in October 13 issue of the New England Journal of Medicine.

A total of 239 babies with a gestational age of 36 weeks or more were enrolled in the study, and 102 were assigned to hypothermia. Infants were randomized within 6 hours of birth and all had either severe acidosis, or perinatal complications and resuscitation at birth. All had moderate to severe encephalopathy.

During the study, infants were randomly assigned to usual care (control group) or whole-body cooling to an esophageal temperature of 33.5°C for 72 hours, followed by slow re-warming (hypothermia group). Neurodevelopmental outcome was assessed at 18 to 22 months of age. The primary outcome was a combined end point of death or moderate or severe disability.

Infants assigned to the hypothermia group were initially placed on an infant-sized cooling blanket that was pre-cooled to 5° C. An esophageal probe was placed and the infant was covered with a second cooling blanket. Esophageal and skin temperatures were monitored every 15 min for four hours, then every hour for next eight hours, and finally every four hours for the remainder of the cooling period. Infants in the control group were cared for with overhead radiant warmers and had skin temperature maintained between 36.5° C and 37.0° C.

After the study, 44% percent of infants randomized to hypothermia died or had disability compared with 62% of infants in the control group. Twenty-four infants died in the hypothermia group, compared with 38 among the controls, but this was not significant. There was no increase in major disability among survivors; the rate of cerebral palsy was 19% in the hypothermia group as compared with 30% in the control group.

The authors conclude that whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic–ischemic encephalopathy. These findings demonstrate the safety and effectiveness of whole-body cooling in reducing the risk of death or disability among infants with moderate or severe encephalopaty.

Related medicine news :

1. Stress reduces your immunity- startling but true!!!!!
2. Thirty minutes of work up per day reduces the risk of Diabetes
3. Aspirin reduces deaths
4. Tomato Sauce reduces Cancer Risk- Study
5. Calcium reduces colon cancer risk
6. New pacemaker reduces risk of heart failure
7. Vitamin D reduces heart risk
8. Back exercises reduces Osteoporosis
9. Caffeine reduces infant blood flow
10. Radiation reduces cancer recurrence
11. Tamoxifen reduces breast cancer risk
Post Your Comments:

(Date:11/26/2015)... ... November 26, 2015 , ... ... retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes ... titles work with any font, giving users limitless opportunities to stylize and create ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... for all, Water For Empowerment ™ attracts volunteers together who want to ... by empowering women as key stakeholders in the process. The non-profit launched its ...
(Date:11/25/2015)... ... 25, 2015 , ... TyloHelo Inc , North America’s ... Sauna accessories help improve the bather experience in the sauna, and the accessories ... the purist looking for simplicity in design to accessories that encourage a greater ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert ... Organizations, One Beat ” campaign. The partnership between the two groups began in 2014 ... MAP International’s cause. , MAP International was founded in 1954 and is an international ...
(Date:11/25/2015)... ... ... On November 25, 2015, officials of Narconon Arrowhead , the drug ... a new cutting edge recovery program that has been 50 years in the making. ... individuals with the purpose to free addicts from the symptoms and negative behaviors of ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  Trovagene, Inc. (NASDAQ: ... today announced that Chief Executive Officer Antonius Schuh, Ph.D., ... 27 th Annual Piper Jaffray Healthcare Conference. ... the New York Palace Hotel in New ... 1:30 p.m. EST. Mr. Schuh will be available for ...
(Date:11/25/2015)... International plc (NASDAQ: ENDP ) (TSX: ENL) today announced ... discuss corporate updates at the 27 th Annual Piper ... on Wednesday, December 2, 2015 at 1 p.m. ET. ... the link to the event. Participants should allow approximately 10 ... site and download any streaming media software needed to listen ...
(Date:11/25/2015)... AVIV, Israel , November 25, 2015 ... (the "New Investors"), pursuant to which BioLight and the ... BioLight,s IOPtima Ltd. subsidiary ("IOPtima") via a private placement. ... commercialization of its innovative IOPtimate™ system used in the ... regulatory approval pathway process for the IOPtimate™ system with ...
Breaking Medicine Technology: